DUPIXENT can cause serious side effects, including:

• Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell
  your healthcare provider or get emergency help right away if you get any of the following signs or symptoms:

• Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or
  changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an eye exam if
  needed.
• Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may
  happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not
  known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain,
  worsening shortness of breath, a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
• Joint aches and pain. Joint aches and pain can happen in people who use DUPIXENT. Some people have had trouble
  walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider
  about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects of DUPIXENT include:

• Eczema: injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with
  blurred vision, dry eye, cold sores in your mouth or on your lips, and high count of a certain white blood cell (eosinophilia).
• Asthma: injection site reactions, high count of a certain white blood cell (eosinophilia), pain in the throat (oropharyngeal
  pain), and parasitic (helminth) infections.
• CRSwNP: injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with
  blurred vision, high count of a certain white blood cell (eosinophilia), gastritis, joint pain (arthralgia), trouble sleeping
  (insomnia), and toothache.
• EoE: injection site reactions, upper respiratory tract infections, cold sores in your mouth or on your lips, and joint pain
  (arthralgia).
• PN: eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, herpes virus
  infections, common cold symptoms (nasopharyngitis), dizziness, muscle pain, and diarrhea.
• Chronic Obstructive Pulmonary Disease: injection site reactions, common cold symptoms (nasopharyngitis), high count of a certain white blood cell
  (eosinophilia), viral infection, back pain, inflammation inside the nose (rhinitis), diarrhea, gastritis, joint pain (arthralgia),
  toothache, headache, and urinary tract infection.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the
possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report
negative side effects to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.