How DUPIXENT is Taken

Debbie

DUPIXENT MyWay® Patient Ambassador,
on DUPIXENT
Individual results may vary.
"I had learned over the years that if I didn't advocate for myself, no one would... It was clear to me that I needed to explore additional treatment options."

DUPIXENT is Administered by Injection

DUPIXENT is a form of medicine called a biologic, and taken by injection under the skin (subcutaneous). After an initial dose of two injections (600 mg) at two different injection sites, DUPIXENT is taken as one injection (300 mg) every other week at different injection sites. DUPIXENT can be used with or without topical corticosteroids.

Use DUPIXENT exactly as prescribed by your healthcare provider. Prior to taking DUPIXENT, talk to your healthcare provider and see the detailed Instructions for Use that comes with DUPIXENT for information on how to prepare and inject DUPIXENT and how to properly store and throw away used DUPIXENT pre-filled syringes.

How to Self-Inject DUPIXENT

If your healthcare provider decides that you or your caregiver can give the injections of DUPIXENT, you or your caregiver should receive training on the right way to prepare and inject DUPIXENT. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider.

Watch the video below for supplemental information on how to use and dispose of DUPIXENT.

Hi there. I’m Laura. Today I’m going to show you how to properly self-inject a dose of DUPIXENT (dupilumab). You’ve already learned how to self-inject with your healthcare provider. I’m here to guide your first at-home experience. When I first started self-injections, I found syringes really intimidating. I’ve gotten better at the process since then, so I want to share those steps with you today. I’ll show you: what supplies to gather, how to prep the injection area, and how to inject the dose and discard your used syringe. If you haven’t yet read the instructions for use located in your treatment packaging, pause the video and take a look. I found it helpful to understand the plunger, syringe body, and needle cap before handling the syringe itself. Contact your healthcare provider or the DUPIXENT MyWay Hotline with any questions. It’s time for me to take my DUPIXENT injection. Feel free to watch me and follow along as I self-inject.

Take your medication out of the refrigerator. Never freeze your syringe. Remove the syringe by holding the middle of the syringe body. Do not use the syringe if it has been dropped on a hard surface or is damaged. Do not pull off the needle cap or touch the plunger rod until you are ready to inject. Do not pull back on the plunger rod at any time. Keep DUPIXENT syringes and all medicines out of the reach of children. If you have an unused syringe, return it to the refrigerator in the original carton to protect it from light. Check the label to make sure the medication inside is correct and the expiration date has not passed. If it isn’t right, contact your pharmacy. You may see an air bubble, this is normal. Do not try to get rid of any air bubbles. The liquid inside should be clear, and colorless to pale yellow. Do not use the syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles. Throw away, dispose of, the used Dupixent single-dose pre-filled syringe right away after use. If you have any questions about whether the syringe is okay to use, please call the DUPIXENT MyWay Hotline.

Lay the syringe on a flat surface and let it naturally warm to room temperature for at least 45 minutes before injection. Do not heat the syringe. Do not put the syringe into direct sunlight. Do not keep DUPIXENT at room temperature for more than 14 days. Throw away, dispose of, any syringe that has been left at room temperature for longer than 14 days. Do not shake the syringe. While you wait, gather the additional materials necessary to self-inject. You need one cotton ball or gauze, one alcohol wipe, and a puncture resistant Sharps Disposal Container. If you don’t have a Sharps Disposal Container, call a DUPIXENT MyWay representative to request a complimentary Sharps Disposal Container.

Now, take your supplies to an area where you can sit comfortably. When you are ready to get started, wash your hands thoroughly. Choose your injection site. Both the stomach and thigh are acceptable, except for the two inches around your belly button. If a caregiver gives you the injection, the outer area of the upper arm is also an option. The person giving the injection should follow the same preparation procedure. Be sure to choose a different site each time you inject DUPIXENT. Do not inject through clothes. Do not inject into skin that is tender, damaged or is bruised or scarred. Clean your skin with the alcohol wipe. Do not touch the injection site again or blow on it before the injection. Let your skin dry before injection. Carefully remove the cap from the syringe. Do not use if the needle cap is missing or not securely attached. Do not put the needle cap back on. Do not touch the needle. Inject the medicine right away after removing the Needle cap. Pinch your skin at the injection site. Pinching your skin helps the medicine go into a fatty layer, just below the skin, and not into the muscle. Take a deep breath. Continue to pinch, as you insert the needle completely at about a 45° angle. Relax your pinch. Push the plunger down slowly and steadily as far as it will go, until the syringe is empty. It’s normal to feel a bit of resistance here. Keep pressing the plunger down, and remove the needle from your skin at the same angle it was inserted. Do not put the needle cap back on. Once the needle is out of your skin, lift your thumb to retract the needle up into the needle shield. Dispose of the syringe and needle cap in the Sharps Disposal Container.

Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once it is full. Do not dispose in household trash. Do not reuse the syringe. If you see any blood at the injection site, gently pat it away with your cotton ball or gauze. You can also cover the site with a bandage. Do not rub your skin after the injection. If you would like to practice before doing the actual injection and you have received the DUPIXENT training kit from your doctor's office, you can practice the 45° injection angle with your training syringe and the angle-aid, and you could always watch the video again. Remember, do not use the angle-aid to administer an actual injection.

Be sure to keep track of your injection date and site. Thank you for joining me today. Remember, you can re-watch this video as often as you like to refresh your memory. Contact your healthcare provider or the DUPIXENT MyWay Hotline with any questions or concerns.

Self-Injection Instructions

Administering DUPIXENT yourself may seem intimidating, but following the instructions below will help reinforce the steps your healthcare provider showed you. Remember, Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider.

  1. Remove
    Remove the DUPIXENT Syringe from the carton by holding the middle of the Syringe Body.
    • Do not pull off the Needle Cap until you are ready to inject.
    • Do not use the DUPIXENT Syringe if it has been dropped on a hard surface or damaged.
  2. Prepare

    Ensure you have the following:

    • DUPIXENT Pre-filled Syringe
    • 1 alcohol wipe*
    • 1 cotton ball or gauze*
    • Sharps Disposal Container* (See Step 13)

    * Items not included in the carton

  1. Inspect
    When you receive your DUPIXENT Syringes, always check to see that:
    • You have the correct medicine and dose.
    • The expiration date on the Single-Dose Pre-filled Syringe has not passed.
      • Do not use the DUPIXENT Syringe if the expiration date has passed.
    • Look at the medicine through the Viewing Window on the DUPIXENT Syringe: Check to see if the liquid is clear and colorless to pale yellow.
    • Note: You may see an air bubble, this is normal.
      • Do not use the DUPIXENT Syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles.
  2. Wait 45 minutes
    Lay the DUPIXENT Syringe on a flat surface and let it naturally warm to room temperature for at least 45 minutes.
    • Do not heat the DUPIXENT Syringe.
    • Do not put the DUPIXENT Syringe into direct sunlight.
    • Do not keep DUPIXENT Syringes at room temperature for more than 14 days. Throw away (dispose of) any DUPIXENT Syringes that have been left at room temperature for longer than 14 days.
  1. Choose your injection site
    Choose your injection site
    • You can inject into your thigh or stomach, except for the 2 inches (5 cm) around your belly button (navel).
    • If a caregiver injects your dose, they can also use the outer area of the upper arm.
    • Choose a different site each time you inject DUPIXENT.
    • Do not inject into skin that is tender, damaged, bruised or scarred.
  2. Clean
    • Wash your hands.
    • Clean the injection site with an alcohol wipe.
    • Let your skin dry before injecting.
    • Do not touch the injection site again or blow on it before the injection.
  1. Remove Needle Cap
    • Hold the DUPIXENT Syringe in the middle of the Syringe Body with the Needle pointing away from you and pull off the Needle Cap.
    • Do not put the Needle Cap back on.
    • Do not touch the Needle. Inject your medicine right away after removing the Needle Cap.
  2. Pinch
    Pinch
    Pinch a fold of skin at the injection site (thigh or stomach, except 2 inches around your belly button, or outer area of the upper arm if injected by your caregiver). The figure on the right shows an example of pinching a fold of skin on your stomach.
  1. Insert
    • Insert the Needle completely into the fold of the skin at about a 45-degree angle.
  2. Push
    • Relax the pinch.
    • Push the Plunger Rod down slowly and steadily as far as it will go, until the DUPIXENT Syringe is empty.
    • Note: You will feel some resistance. This is normal.
  1. Remove
    • Keep pressing down on the Plunger and remove the Needle from the skin at the same angle it was inserted.
    • Do not put the Needle Cap back on.
  2. Release
    • Once the Needle is out of the skin, lift your thumb to retract the Needle up into the Needle Shield.
    • Lightly press a cotton ball or gauze on the injection site if you see any blood.
    • Do not rub your skin after the injection.
  1. Dispose
    • Put your used Needles, DUPIXENT Syringes, and Needle Caps in an FDA-cleared sharps disposal container right away after use.
    • Do not dispose of (throw away) Needles, DUPIXENT Syringes, and Needle Caps in your household trash.
    • If you do not have a FDA-cleared sharps disposal container, you may use a household container that is:
      • Made of a heavy-duty plastic,
      • Can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
      • Upright and stable during use,
      • Leak-resistant, and
      • Properly labeled to warn of hazardous waste inside the container
    • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container.
    • There may be state or local laws about how you should throw away used Needles and Syringes. For more information about safe sharps disposal and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal.
    • Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container.
    • Do not put the Needle Cap back on.
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