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How DUPIXENT is Taken

Knowing how to properly take DUPIXENT is important. Your healthcare provider will show you how to use DUPIXENT. View the video below for more information. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider.

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DUPIXENT is an injectable medicine called a biologic that is FDA-approved for the treatment of moderate-to-severe eczema (atopic dermatitis) in adults who are not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children.

Hi there. I’m Laura. Today I’m going to show you how to properly self-inject a dose of DUPIXENT (dupilumab). You’ve already learned how to self-inject with your healthcare provider. I’m here to guide your first at-home experience. When I first started self-injections, I found syringes really intimidating. I’ve gotten better at the process since then, so I want to share those steps with you today. I’ll show you: what supplies to gather, how to prep the injection area, and how to inject the dose and discard your used syringe. If you haven’t yet read the instructions for use located in your treatment packaging, pause the video and take a look. I found it helpful to understand the plunger, syringe body, and needle cap before handling the syringe itself. Contact your healthcare provider or the DUPIXENT MyWay Hotline with any questions. It’s time for me to take my DUPIXENT injection. Feel free to watch me and follow along as I self-inject.

Take your medication out of the refrigerator. Never freeze your syringe. Remove the syringe by holding the middle of the syringe body. Do not use the syringe if it has been dropped on a hard surface or is damaged. Do not pull off the needle cap or touch the plunger rod until you are ready to inject. Do not pull back on the plunger rod at any time. Keep DUPIXENT syringes and all medicines out of the reach of children. If you have an unused syringe, return it to the refrigerator in the original carton to protect it from light. Check the label to make sure the medication inside is correct and the expiration date has not passed. If it isn’t right, contact your pharmacy. You may see an air bubble, this is normal. Do not try to get rid of any air bubbles. The liquid inside should be clear, and colorless to pale yellow. Do not use the syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles. Throw away, dispose of, the used Dupixent single-dose pre-filled syringe right away after use. If you have any questions about whether the syringe is okay to use, please call the DUPIXENT MyWay Hotline.

Lay the syringe on a flat surface and let it naturally warm to room temperature for at least 45 minutes before injection. Do not heat the syringe. Do not put the syringe into direct sunlight. Do not keep DUPIXENT at room temperature for more than 14 days. Throw away, dispose of, any syringe that has been left at room temperature for longer than 14 days. Do not shake the syringe. While you wait, gather the additional materials necessary to self-inject. You need one cotton ball or gauze, one alcohol wipe, and a puncture resistant Sharps Disposal Container. If you don’t have a Sharps Disposal Container, call a DUPIXENT MyWay representative to request a complimentary Sharps Disposal Container.

Now, take your supplies to an area where you can sit comfortably. When you are ready to get started, wash your hands thoroughly. Choose your injection site. Both the stomach and thigh are acceptable, except for the two inches around your belly button. If a caregiver gives you the injection, the outer area of the upper arm is also an option. The person giving the injection should follow the same preparation procedure. Be sure to choose a different site each time you inject DUPIXENT. Do not inject through clothes. Do not inject into skin that is tender, damaged or is bruised or scarred. Clean your skin with the alcohol wipe. Do not touch the injection site again or blow on it before the injection. Let your skin dry before injection. Carefully remove the cap from the syringe. Do not use if the needle cap is missing or not securely attached. Do not put the needle cap back on. Do not touch the needle. Inject the medicine right away after removing the Needle cap. Pinch your skin at the injection site. Pinching your skin helps the medicine go into a fatty layer, just below the skin, and not into the muscle. Take a deep breath. Continue to pinch, as you insert the needle completely at about a 45° angle. Relax your pinch. Push the plunger down slowly and steadily as far as it will go, until the syringe is empty. It’s normal to feel a bit of resistance here. Keep pressing the plunger down, and remove the needle from your skin at the same angle it was inserted. Do not put the needle cap back on. Once the needle is out of your skin, lift your thumb to retract the needle up into the needle shield. Dispose of the syringe and needle cap in the Sharps Disposal Container.

Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once it is full. Do not dispose in household trash. Do not reuse the syringe. If you see any blood at the injection site, gently pat it away with your cotton ball or gauze. You can also cover the site with a bandage. Do not rub your skin after the injection. If you would like to practice before doing the actual injection and you have received the DUPIXENT training kit from your doctor's office, you can practice the 45° injection angle with your training syringe and the angle-aid, and you could always watch the video again. Remember, do not use the angle-aid to administer an actual injection.

Be sure to keep track of your injection date and site. Thank you for joining me today. Remember, you can re-watch this video as often as you like to refresh your memory. Contact your healthcare provider or the DUPIXENT MyWay Hotline with any questions or concerns.

IMPORTANT SAFETY INFORMATION

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have eye problems
  • have a parasitic (helminth) infection
  • have asthma
  • are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. If you have asthma and are taking asthma medicines, do not change or stop your asthma medicine without talking to your healthcare provider.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions. Stop using DUPIXENT and go to the nearest hospital emergency room if you get any of the following symptoms: fever, general ill feeling, swollen lymph nodes, hives, itching, joint pain, or skin rash.
  • Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision.

The most common side effects include injection site reactions, eye and eyelid inflammation, including redness, swelling and itching, and cold sores in your mouth or on your lips.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed. If your healthcare provider decides that you or a caregiver can give DUPIXENT injections, you or your caregiver should receive training on the right way to prepare and inject DUPIXENT. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider.

Please see accompanying full Prescribing Information including Patient Information.

INDICATION

DUPIXENT is a prescription medicine used to treat adult patients with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children.


After an initial dose of two injections (600 mg), DUPIXENT is taken as one injection (300 mg) every other week at different injection sites.

  • Use DUPIXENT exactly as prescribed by your healthcare provider.
  • DUPIXENT comes as a single-dose pre-filled syringe with needle shield.
  • DUPIXENT is given as an injection under the skin (subcutaneous injection).
  • If your healthcare provider decides that you or a caregiver can give the injections of DUPIXENT, you or your caregiver should receive training on the right way to prepare and inject DUPIXENT. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider.
  • If you miss a dose of DUPIXENT, give the injection within 7 days from the missed dose, then continue with the original schedule. If the missed dose is not given within 7 days, wait until the next scheduled dose to give your DUPIXENT injection.
  • If you inject more DUPIXENT than prescribed, talk to your healthcare provider right away.
  • Your healthcare provider may prescribe other topical medicines to use with DUPIXENT. Use the other prescribed topical medicines exactly as your healthcare provider tells you to.
  • Before injection, remove DUPIXENT pre-filled syringe from the refrigerator, lay the DUPIXENT syringe on a flat surface and let it naturally warm to room temperature for at least 45 minutes.
  • DUPIXENT is colorless to pale yellow. Inspect DUPIXENT visually and do not use the DUPIXENT syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles.
  • Do not use the DUPIXENT syringe if it has been dropped on a hard surface or damaged.

Read the detailed Instructions for Use on how to prepare and inject DUPIXENT and how to properly store and throw away (dispose of) used DUPIXENT pre-filled syringes prior to administration.

Call 1-844-DUPIXENT
(1-844-387-4936)
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