About DUPIXENT

Actor portrayal;
individual results vary

How Can DUPIXENT Help Your Teen?

What if there was a way to help manage the eczema symptoms that bother your teen the most?

DUPIXENT is the first treatment of its kind that can help achieve clearer skin in teens ages 12-17 with moderate-to-severe eczema (atopic dermatitis). It reduces the inflammation underneath the surface that can contribute to the itching and rashes, and can help continuously manage your teen’s eczema, even after their skin looks clearer.

DUPIXENT Demonstrated Results and Safety

DUPIXENT was studied in a 16-week clinical trial with 251 patients* ages 12-17 with moderate-to-severe eczema not adequately controlled with topical prescription treatments. The safety results of DUPIXENT observed in adolescents were consistent with what was seen in adults with atopic dermatitis.

What you should know about the patients in this study:

  • 46% had moderate atopic dermatitis
  • 54% had severe atopic dermatitis
  • Average age ≈15 years old
  • Average body surface area involvement ≈57%
  • 92% had at least one other allergic condition

In a 16-week clinical trial of teens ages 12-17,
significantly more taking DUPIXENT saw:

CLEARER SKIN

Clear or almost clear skin (24% vs 2% in those not taking it)

“For so long we’ve tried to treat eczema on the surface. I never thought the problem might be on the inside.”

Debbie

Parent of patient treated with DUPIXENT

SKIN IMPROVEMENT

Had 75% skin improvement (42% vs. 8% in those not taking it)

“I feel like I’ve tried everything to get my eczema under control, and it looks like I found something that works.”

Jessica, age 16

DUPIXENT MyWay® Patient Ambassador, treated with DUPIXENT

Individual result may vary

LESS ITCHING

Experienced noticeable itch reduction (37% vs 5% in those not taking it)

“We talked it over, but the chance to control the itching and rashes easily outweighed giving the injection.”

Charlotte

Parent of patient treated with DUPIXENT

The most common side effects include injection site reactions, eye and eyelid inflammation, including redness, swelling and itching, pain in the throat (oropharyngeal pain) and cold sores in your mouth or on your lips.

*Patients who weighed ≥60kg received DUPIXENT 300 mg every two weeks after an initial dose of 600 mg and patients who weighed <60 kg received DUPIXENT 200 mg every two weeks after an initial dose of 400 mg

DUPIXENT was studied in 3 clinical trials with more than 2,100 adults with uncontrolled
moderate-to-severe eczema (atopic dermatitis) and approved for use in adults on March 28, 2017.

Connect With a Specialist
Who Treats Eczema

Consult with your teen’s doctor and then use this tool to easily find nearby specialists with experience in treating teens and adults with uncontrolled moderate-to-severe eczema (atopic dermatitis).

Sanofi US and Regeneron do not endorse or recommend any particular physician, and search results do not include a comprehensive list of doctors in your area.

How to Administer DUPIXENT

If your teen’s healthcare provider decides that you or your teen can give the injections of DUPIXENT, you or your teen should receive training on the right way to prepare and inject DUPIXENT. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider. In teens ages 12-17, it is recommended that DUPIXENT be administered by or under the supervision of an adult.

Watch the video below for supplemental information on how to use and dispose of DUPIXENT.

MOM: Since you’re watching this video, I know you’ve already learned how to give an injection with your healthcare provider. I’m just here to help guide you through your first at-home experience.

When I first started giving injections, I found syringes really intimidating. I've gotten better at the process since then, so I wanted to share those steps with you today.

If you haven’t yet read the Instructions for Use located in your treatment packaging, pause the video and take a look. And if you have any questions along the way, don’t hesitate to reach out to your healthcare provider or the DUPIXENT MyWay hotline. They’re always there to help.

MOM: Are you ready? …OK

Are you ready?

SON: What?

MOM: Let’s show them how to properly inject a dose of DUPIXENT.

SON: Oh, sure.

MOM: First, take your medication out of the refrigerator. Never freeze your syringe.

Remove the syringe by holding the middle of the syringe body.

A few things to remember:

  • Do not use the syringe if it has been dropped on a hard surface or is damaged.
  • Do not pull off the needle cap or touch the plunger rod until you are ready to inject.
  • Do not pull back on the plunger rod at any time.
  • Keep DUPIXENT syringes and all medicines out of the reach of children.
  • If you have an unused syringe, return it to the refrigerator in the original carton to protect it from light.

Your DUPIXENT pre-filled syringe may appear different from what you see in this video, based on the prescribed dose. If you have questions about the dosage prescribed, please contact your healthcare provider.

OK, now it’s time to check the label to make sure the medication and dosage are correct and the expiration date has not passed. If it isn’t right, contact your pharmacy.

SON: Looks right to me.

MOM: Yup.

Now look at the medicine through the Viewing Window on the DUPIXENT syringe. The liquid inside should be clear and colorless to pale yellow. You may see an air bubble; this is normal. Do not try to get rid of any air bubbles.

Do not use the syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles.

Throw away, dispose of, the used DUPIXENT single-dose, pre-filled syringe right away after use.

If you have any questions about whether the syringe is OK to use, please call the DUPIXENT MyWay hotline, or your healthcare provider.

Lay the syringe on a flat surface and let it naturally warm to room temperature. The recommended warming time for the 200mg syringe is 30 minutes, and for the 300mg syringe it's 45 minutes.

Here are a few more things to remember:

  • Do not heat the syringe.
  • Do not put the syringe into direct sunlight.
  • Do not keep DUPIXENT at room temperature for more than 14 days. Throw away any syringe that has been left at room temperature for longer than 14 days.
  • Do not shake the syringe.

While you wait, gather the additional necessary materials.

You need one cotton ball or gauze.

SON: Check.

MOM: One alcohol wipe.

SON: Check.

MOM: And a puncture-resistant sharps disposal container.

SON: Check.

MOM: If you don’t have a sharps disposal container, call a DUPIXENT MyWay representative to request a complimentary sharps disposal container.

When you are ready to get started, wash your hands thoroughly.

Now, take your supplies to an area where you can sit comfortably.

Choose your injection site. Both the stomach and thigh are acceptable, except for the two inches around the belly button. The outer area of the upper arm is also an option since you are giving the injection to someone, but not if you’re self-injecting.

Be sure to choose a different site each time you inject DUPIXENT.

  • Do not inject through clothes.
  • Do not inject into skin that is tender, damaged, bruised, or scarred.

OK, now clean the skin with the alcohol wipe.

Do not touch the injection site again or blow on it before the injection.

Once the skin is dry, hold the DUPIXENT syringe in the middle of the syringe body with the needle pointing away from you and carefully remove the cap from the syringe.

  • Do not use if the needle cap is missing or not securely attached.
  • Do not put the needle cap back on.
  • Do not touch the needle. Inject the medicine right away after removing the needle cap.

Pinch a fold of skin at the injection site. Pinching the skin helps the medicine go into a fatty layer, just below the skin, and not into the muscle.

Take a deep breath.

Continue to pinch as you insert the needle completely at about a 45° angle.

Relax your pinch.

Push the plunger down slowly and steadily as far as it will go, until the syringe is empty. You will feel some resistance. This is normal.

Lift your thumb to release the plunger rod until the needle is covered by the needle shield and then remove the syringe from the injection site.

Lightly press a cotton ball or gauze on the injection site if you see any blood. Do not put the needle cap back on, and do not rub the skin after the injection.

SON: Got it.

MOM: You can also cover the site with a bandage.

OK, now put the used DUPIXENT syringe and cap in an FDA-cleared sharps disposal container right away after use.

Do not put DUPIXENT syringes in your household trash. Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once it is full.

Do not recycle your used sharps disposal container. And do not reuse the syringe.

If you would like to practice before doing the actual injection and you have received the DUPIXENT training kit from your doctor's office, you can practice the 45° injection angle with the training syringe and the angle aid. Do not use the angle aid to administer an actual injection.

Finally, always be sure to keep track of the injection date and site.

Well, now you know how to give a dose of DUPIXENT. If you follow these steps, you’ll be a pro in no time.

Feel free to rewatch this video as many times as you’d like. And again, reach out to your healthcare provider or call the DUPIXENT MyWay hotline if you have any questions.

Well, that wasn’t so bad, was it?

SON: What?

Injection Instructions

Administering DUPIXENT may seem intimidating, but following the instructions below will help reinforce the steps your healthcare provider showed you and your teen. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider.

1

Remove

Remove the DUPIXENT Syringe from the carton by holding the middle of the Syringe Body.

  • Do not pull off the Needle Cap until you are ready to inject.
  • Do not use the DUPIXENT Syringe if it has been dropped on a hard surface or damaged.

2

Prepare

Ensure you have the following:

  • DUPIXENT Pre-filled Syringe
  • 1 alcohol wipe*
  • 1 cotton ball or gauze*
  • Sharps Disposal Container* (See Step 13)

* Items not included in the carton

3

Check

When you receive your DUPIXENT Syringes, always check to see that:

  • You have the correct medicine and dose.
  • The expiration date on the Single-Dose Pre-filled Syringe has not passed.
    • Do not use the DUPIXENT Syringe if the expiration date has passed.

4

Inspect

  • Look at the medicine through the Viewing Window on the DUPIXENT Syringe: Check to see if the liquid is clear and colorless to pale yellow.
  • Note: You may see an air bubble, this is normal.
    • Do not use the DUPIXENT Syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles.

5

Wait 30 minutes

Lay the DUPIXENT Syringe on a flat surface and let it naturally warm to room temperature for at least 30 minutes.

  • Do not heat the DUPIXENT Syringe.
  • Do not put the DUPIXENT Syringe into direct sunlight.
  • Do not keep DUPIXENT Syringes at room temperature for more than 14 days. Throw away (dispose of) any DUPIXENT Syringes that have been left at room temperature for longer than 14 days.

6

Choose your injection site

  • You can inject into your thigh or stomach, except for the 2 inches (5 cm) around your belly button (navel).
  • If a caregiver injects your dose, they can also use the outer area of the upper arm.
  • Choose a different site each time you inject DUPIXENT.
  • Do not inject into skin that is tender, damaged, bruised or scarred.

7

Clean

  • Wash your hands.
  • Clean the injection site with an alcohol wipe.
  • Let your skin dry before injecting.
  • Do not touch the injection site again or blow on it before the injection.

8

Remove Needle Cap

  • Hold the DUPIXENT Syringe in the middle of the Syringe Body with the Needle pointing away from you and pull off the Needle Cap.
  • Do not put the Needle Cap back on.
  • Do not touch the Needle.
    Inject your medicine right away after removing the Needle Cap.

9

Pinch

Pinch a fold of skin at the injection site (thigh or stomach, except 2 inches around your belly button, or outer area of the upper arm if injected by your caregiver). The figure shows an example of pinching a fold of skin on your stomach.

10

Insert

  • Insert the Needle completely into the fold of the skin at about a 45-degree angle.

11

Push

  • Relax the pinch.
  • Push the Plunger Rod down slowly and steadily as far as it will go, until the DUPIXENT Syringe is empty.
  • Note: You will feel some resistance. This is normal.

12

Release and Remove

  • Lift your thumb to release the Plunger Rod until the Needle is covered by the Needle Shield and then remove the Syringe from the injection site.
  • Do not put the Needle Cap back on.
  • Do not rub your skin after the injection.
  • Lightly press a cotton ball or gauze on the injection site if you see any blood.

13

Dispose

  • Put your used Needles, DUPIXENT Syringes and Needle Caps in an FDA-cleared sharps disposal container right away after use.
  • Do not dispose of (throw away) Needles, DUPIXENT Syringes and Needle Caps in your household trash.
  • If you do not have an FDA-cleared sharps disposal container, you may use a household container that is:
    • Made of a heavy-duty plastic,
    • Can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
    • Upright and stable during use,
    • Leak-resistant, and
    • Properly labeled to warn of hazardous waste inside the container
  • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used Needles and Syringes.
  • For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal.
  • Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container.
  • Do not put the Needle Cap back on.

1

Remove

Remove the DUPIXENT Syringe from the carton by holding the middle of the Syringe Body.

  • Do not pull off the Needle Cap until you are ready to inject.
  • Do not use the DUPIXENT Syringe if it has been dropped on a hard surface or damaged.

2

Prepare

Ensure you have the following:

  • DUPIXENT Pre-filled Syringe
  • 1 alcohol wipe*
  • 1 cotton ball or gauze*
  • Sharps Disposal Container* (See Step 13)

* Items not included in the carton

3

Check

When you receive your DUPIXENT Syringes, always check to see that:

  • You have the correct medicine and dose.
  • The expiration date on the Single-Dose Pre-filled Syringe has not passed.
    • Do not use the DUPIXENT Syringe if the expiration date has passed.

4

Inspect

  • Look at the medicine through the Viewing Window on the DUPIXENT Syringe: Check to see if the liquid is clear and colorless to pale yellow.
  • Note: You may see an air bubble, this is normal.
    • Do not use the DUPIXENT Syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles.

5

Wait 45 minutes

Lay the DUPIXENT Syringe on a flat surface and let it naturally warm to room temperature for at least 45 minutes.

  • Do not heat the DUPIXENT Syringe.
  • Do not put the DUPIXENT Syringe into direct sunlight.
  • Do not keep DUPIXENT Syringes at room temperature for more than 14 days. Throw away (dispose of) any DUPIXENT Syringes that have been left at room temperature for longer than 14 days.

6

Choose your injection site

  • You can inject into your thigh or stomach, except for the 2 inches (5 cm) around your belly button (navel).
  • If a caregiver injects your dose, they can also use the outer area of the upper arm.
  • Choose a different site each time you inject DUPIXENT.
  • Do not inject into skin that is tender, damaged, bruised or scarred.

7

Clean

  • Wash your hands.
  • Clean the injection site with an alcohol wipe.
  • Let your skin dry before injecting.
  • Do not touch the injection site again or blow on it before the injection.

8

Remove Needle Cap

  • Hold the DUPIXENT Syringe in the middle of the Syringe Body with the Needle pointing away from you and pull off the Needle Cap.
  • Do not put the Needle Cap back on.
  • Do not touch the Needle.
    Inject your medicine right away after removing the Needle Cap.

9

Pinch

Pinch a fold of skin at the injection site (thigh or stomach, except 2 inches around your belly button, or outer area of the upper arm if injected by your caregiver). The figure shows an example of pinching a fold of skin on your stomach.

10

Insert

  • Insert the Needle completely into the fold of the skin at about a 45-degree angle.

11

Push

  • Relax the pinch.
  • Push the Plunger Rod down slowly and steadily as far as it will go, until the DUPIXENT Syringe is empty.
  • Note: You will feel some resistance. This is normal.

12

Release and Remove

  • Lift your thumb to release the Plunger Rod until the Needle is covered by the Needle Shield and then remove the Syringe from the injection site.
  • Do not put the Needle Cap back on.
  • Do not rub your skin after the injection.
  • Lightly press a cotton ball or gauze on the injection site if you see any blood.

13

Dispose

  • Put your used Needles, DUPIXENT Syringes and Needle Caps in an FDA-cleared sharps disposal container right away after use.
  • Do not dispose of (throw away) Needles, DUPIXENT Syringes and Needle Caps in your household trash.
  • If you do not have an FDA-cleared sharps disposal container, you may use a household container that is:
    • Made of a heavy-duty plastic,
    • Can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
    • Upright and stable during use,
    • Leak-resistant, and
    • Properly labeled to warn of hazardous waste inside the container
  • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used Needles and Syringes.
  • For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal.
  • Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container.
  • Do not put the Needle Cap back on.