Frequently Asked

Learn About DUPIXENT

To help you understand uncontrolled moderate-to-severe asthma and how DUPIXENT may help treat it, we’ve provided answers to the most common questions. As always, be sure to ask your doctor any additional questions you may have.


DUPIXENT is a prescription medicine used as an add-on maintenance treatment for people 12 and up who have moderate-to-severe eosinophilic or oral steroid dependent asthma that is not controlled with their current asthma medicines. DUPIXENT is not used to treat sudden breathing problems.


DUPIXENT blocks two key sources of inflammation in your lungs to help prevent asthma attacks and reduce asthma symptoms.

Do not use DUPIXENT if you are allergic to dupilumab or to any of the ingredients in DUPIXENT.

Before using DUPIXENT, tell your doctor about all your medical conditions, including if you:

  • have a parasitic (helminth) infection.
  • are scheduled to receive any vaccinations. You should not receive a "live vaccine" if you are treated with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
    • There is a pregnancy exposure registry for women who take DUPIXENT during pregnancy to collect information about the health of you and your baby. Your healthcare provider can enroll you or you may enroll yourself. To get more information about the registry call 1-877-311-8972 or go to
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines; have asthma and use an asthma medicine; and have atopic dermatitis or CRSwNP, and also have asthma. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine to come back.

The efficacy of DUPIXENT has been studied in 3 clinical trials with 2,888 people 12 years of age and older with moderate-to-severe asthma.

Patients enrolled in Trials 1 and 2 were required to have a history of 1 or more asthma exacerbations that required treatment with systemic corticosteroids or emergency department visit or hospitalization for the treatment of asthma in the year prior to trial entry.

Patients enrolled in Trial 3 required dependence on daily oral corticosteroids in addition to regular use of high-dose inhaled corticosteroids plus an additional controller(s).

View complete results

DUPIXENT can cause serious side effects, including:

  • Allergic reactions (hypersensitivity), including a severe reaction known as anaphylaxis. Stop using DUPIXENT and go to the nearest hospital emergency room if you get any of the following symptoms:

    • breathing problems
    • fever
    • general ill feeling
    • swollen lymph nodes
    • swelling of the face, mouth, and tongue
    • hives
    • itching
    • fainting, dizziness, feeling lightheaded (low blood pressure)
    • joint pain
    • skin rash
  • Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your doctor right away if you have:

    • rash
    • shortness of breath
    • persistent fever
    • chest pain
    • a feeling of pins and needles or numbness of your arms or legs

The most common side effects of DUPIXENT include:

  • injection site reactions
  • pain in the throat (oropharyngeal pain)
  • high count of a certain white blood cell (eosinophilia)
Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.


DUPIXENT is given as an injection under the skin (subcutaneous injection) at different injection sites. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider.

The recommended dose of DUPIXENT for adults and adolescents (12 years of age and older) is:

Initial Dose Subsequent Doses
Adults, adolescents (12 years of age and older)
400 mg;
two 200‑mg
200 mg
every 2 weeks
600 mg;
two 300‑mg
300 mg
every 2 weeks
Patients with oral-steroid dependent asthma or with moderate-to-severe atopic dermatitis
600 mg;
two 300-mg
300 mg
every 2 weeks

Talk to your healthcare provider and see the detailed Instructions for Use that comes with DUPIXENT for information on how to prepare and inject DUPIXENT and how to properly store and throw away (dispose of) used DUPIXENT Pre-filled Syringes or DUPIXENT Pre-filled Pens prior to taking the drug.

Watch videos, learn how to administer DUPIXENT, and more.

Visit the injection support

Get the Pre-filled syringe Instructions for use

Get the Pre-filled Pen Instructions for use

DUPIXENT can be injected into the thigh, stomach (except for the 2 inches around the belly button), or outer area of the upper arm (if caregiver injects). A different site should be chosen each time DUPIXENT is injected.

  • Use DUPIXENT exactly as prescribed. Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it.
  • Follow your healthcare provider's instructions and read the Instructions for Use for full details on preparation, administration, and disposal of your injection.

Get the Pre-filled syringe Instructions for use

Get the Pre-filled Pen Instructions for use

Download 300 mg
Instructions for use

If you miss a dose, you should administer the injection within 7 days from the missed dose and then resume the original dose schedule. If the missed dose is not administered within 7 days, you should wait until the next dose on the original schedule. Speak with your healthcare provider before making any change to your treatment regimen.

set up injection reminders

No, you should always follow your healthcare provider’s instructions for dosing and how to give injections.


DUPIXENT should be refrigerated at 36°F to 46°F in the original carton to protect from light. If necessary, DUPIXENT may be kept at room temperature up to 77°F (25°C) for a maximum of 14 days. Do not store above 77°F (25°C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded.

Do not expose DUPIXENT to heat or direct sunlight.

Do not freeze. Do not shake.

Please refer to the DUPIXENT Instructions for Use for complete storage instructions.

Whether you are traveling or not, it’s important to store DUPIXENT in the original carton to protect it from light.

Store refrigerated at 36°F to 46°F (2°C to 8°C) in the original carton to protect from light. If necessary, DUPIXENT may be kept at room temperature up to 77°F (25°C) for a maximum of 14 days. Do not store above 77°F (25°C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded.

Access and Patient Support

Yes. You can continue to receive injection support from your doctor or our Injection Support Center, or if your doctor decides that you or your caretaker can give injections, your doctor will train you. Do not self-adminster DUPIXENT unless you have been trained by a doctor. Patients enrolled in DUPIXENT MyWay® will also have access to their nurse educator to help with supplemental training.

For more information about DUPIXENT support and resources, you can enroll in DUPIXENT MyWay®, a program that can provide:

  • Tips and tools to help with your uncontrolled moderate-to-severe asthma.
  • Supplemental injection training. Your doctor will show you the proper procedure first and decide whether you can self-inject.
  • Financial support for eligible commercially insured patients.
  • Assistance with insurance questions.
  • Assistance locating a pharmacy that can dispense your DUPIXENT prescription.

Sign up or call a support coordinator at 1-844-DUPIXENT (1-844-387-4936) to learn more.

Learn about dupixent MyWay

You can use our Cost and Coverage Tool to learn more about cost options for your insurance situation. For the most accurate information regarding your cost and dispensing of DUPIXENT, speak with your insurance provider who knows the details of your plan.

use the cost and coverage tool

DUPIXENT is likely to be accessed differently than your other medications. DUPIXENT is an injectable medication that requires special shipping and handling. Insurance providers often require use of a specialty pharmacy instead of your local retail pharmacy. DUPIXENT MyWay® can work with your insurance provider to identify a preferred, in-network specialty pharmacy.

Learn how to order dupixent

Notify your pharmacy. In fact, when you take medications that require refills regularly over time, it’s always good to periodically check that your pharmacy has your most up-to-date insurance information on file. This can help you avoid potential delays in getting your prescription.

Contact 1-844-DUPIXENT (1-844-387-4936) to speak to a DUPIXENT MyWay® Nurse Educator, if you have additional questions.

With the DUPIXENT MyWay Copay Card, eligible, commercially insured patients may pay as little as $0* copay per fill of DUPIXENT (maximum of $13,000 per patient per calendar year) if they meet the eligibility requirements, including:

  • Have commercial insurance, including health insurance exchanges, federal employee plans, or state employee plans.
  • Are a resident of the 50 United States, the District of Columbia, or Puerto Rico.
  • Are prescribed DUPIXENT for an indication approved by the US Food and Drug Administration.
*Approval is not guaranteed. THIS IS NOT INSURANCE. Program has an annual maximum of $13,000. Not valid for prescriptions paid, in whole or in part, by Medicaid, Medicare, VA, DOD, TRICARE, or other federal or state programs including any state pharmaceutical assistance programs. This program is not valid where prohibited by law, taxed, or restricted. DUPIXENT MyWay® reserves the right to rescind, revoke, terminate, or amend this offer, eligibility, and terms of use at any time without notice. Any savings provided by the program may vary depending on patients' out-of-pocket costs. Upon registration, patients will receive all program details. Additional terms and conditions apply.

If your health plan did not accept the copay card or if you paid the copay because you were not enrolled in this program, we may be able to reimburse you in accordance with program terms.

get the copay reimbursement form


Through the Patient Assistance Program, eligible patients who are uninsured or whose insurance does not cover DUPIXENT could receive DUPIXENT free of charge.

Those who may qualify must be at least 18 years of age or older, a resident of the 50 United States, the District of Columbia, or Puerto Rico, and demonstrate a financial need with a total annual adjusted gross income of $100,000 or less.

The DUPIXENT MyWay team will research each patient’s situation and determine eligibility. For more information, call 1-844-DUPIXENT (1-844-387-4936), option 1.