Dupixent MyWay® Educational Program

Coming Together for an Informative Conversation

View the video below to learn more about uncontrolled moderate-to-severe atopic dermatitis and a
potential treatment option called DUPIXENT. If you still have questions after watching the video,
consult with your healthcare provider.

SCOTT CORBIN:

Hello. My name is Scott Corbin, and I'm here today on behalf of Regeneron and Sanofi Genzyme. Thank you so much for joining us today for the DUPIXENT MyWay® program. We're going to have an informative conversation about uncontrolled moderate-to-severe atopic dermatitis and DUPIXENT as a potential treatment option.

This program is designed for educational purposes only, and this is not intended to take the place of a conversation that should be happening between you and your personal healthcare provider, and our speaker today is not here to diagnose or treat moderate-to-severe atopic dermatitis, but she is here to present approved educational material.

A few disclosures: This program is intended to provide general information about DUPIXENT, or dupilumab. Regeneron and Sanofi Genzyme are sponsoring this presentation, and not only are the speakers presenting on behalf of Regeneron and Sanofi Genzyme, but they're also being compensated by Regeneron and Sanofi Genzyme, and speakers are presenting information that is consistent with the FDA-approved prescribing information and applicable FDA regulations and guidelines, and if you have any questions about your specific experience, you should speak to your own physician. Your healthcare professional is the single best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment. The health information contained within this program is provided for general educational purposes only.

In today's presentation, we're going to share information about uncontrolled moderate-to-severe atopic dermatitis. We're also going to be providing an overview of DUPIXENT, which is a first of its kind treatment for uncontrolled moderate-to-severe atopic dermatitis. We will share results from the DUPIXENT clinical studies as well as very important safety information.

We'll also discuss the DUPIXENT MyWay Program, which offers great resources to those prescribed DUPIXENT, and we'll be reviewing that program in detail. And joining us later we'll have a DUPIXENT MyWay Patient Ambassador here to tell her story and her experience with atopic dermatitis and DUPIXENT. And I just want to make sure everyone's aware that that is her experience, and DUPIXENT experiences may vary person to person.

It is our hope at the conclusion of this program that you feel informed, you feel inspired to be an active participant in your healthcare team, and you're also working with your healthcare professional to develop your treatment goals.

Some Important Safety Information for DUPIXENT: Do not use if you're allergic to dupilumab or any of the ingredients in DUPIXENT. Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you have eye problems, if you have a parasitic infection, if you are taking oral, topical or inhaled corticosteroid medicines. Do not stop taking your corticosteroid medicines unless instructed by your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine to come back.

Also, talk to your healthcare provider if you are scheduled to receive any vaccinations. You should not receive a live vaccination if you are treated with DUPIXENT. Also, tell your provider if you are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby, and also tell your provider if you are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breastmilk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. If you're taking asthma medicines, do not change or stop your asthma medicine without talking to your healthcare provider first.

Now, we're going to take a few minutes to complete the Eczema Check In, and that also can be found on DUPIXENT.com.

So, what is atopic dermatitis? When it comes to managing your moderate-to-severe atopic dermatitis, the more you know, the better. And so, right now, it's my distinct pleasure to introduce Dr. Kate Sowerwine. She is a board-certified allergist and immunologist. Thank you, Kate, for joining us.

(Applause)

DR. KATE SOWERWINE:

So, as Scott said, my name is Kate Sowerwine. I am an allergist-immunologist, and I am happy to speak to you more about atopic dermatitis today.

So, is it eczema or is it atopic dermatitis? the most common type of eczema is atopic dermatitis. Atopic dermatitis is a chronic disease, and it is not just the visible rash you see in someone with scaly skin, but it's actually inflammation underneath that rash that you're not able to visualize.

Atopic dermatitis is an immunological disease, so therefore, it involves the immune system. Normally, you have a good barrier, and you're not able to overreact to things in the environment, such as allergens and irritants and bacteria. However, those with atopic dermatitis have an overreactive immune system, and they respond to things they're not supposed to respond to.

The reaction is excessive, and it can cause flares. That same reaction is actually still present even between flares. Symptoms of atopic dermatitis are the visual signs and symptoms you see. You have the redness, the erythema. You have cracked, scaly skin. It can even be oozing and weeping. After long, chronic eczema, you can get thickened skin as well. So, these are some of the signs and symptoms that you see of eczema or atopic dermatitis.

People with normal skin don't have inflammation under their skin, but people with eczema or atopic dermatitis have inflammation under the skin.

Atopic dermatitis usually presents on the face, hands, elbows, knees and ankles of patients with atopic dermatitis.

The hallmark symptom of atopic dermatitis – what most people complain about – about 86 percent of patients with atopic dermatitis during a flare complain of itch, and it's a deep itch, and they tend to scratch it because it's difficult not to, so you have an itch that they scratch, and once they scratch that causes inflammation to come to the surface, and this cycle starts again, because that inflammation produces signals to increase the itch, so it's very difficult to break that cycle.

One of the scales that is commonly used in clinical practice is a zero to four-point scale, and that is if you have a score of zero, you have clear skin. If you have a score of four, you have severe atopic dermatitis.

Nearly 8 million adults in the United States has eczema or atopic dermatitis. 1.6 million adult patients have uncontrolled moderate-to-severe atopic dermatitis, and often the negative impact of atopic dermatitis is misunderstood.

There are multiple treatment options that your physicians may prescribe for your moderate-to-severe atopic dermatitis. One example of a medication that can be given to you by your doctor is prescription topical therapies. Other options include immuno-suppressants. Immunosuppressants are medications you take by mouth to decrease your immune system and cause immunosuppression of the immune system. Other options include phototherapy, or lightbox, as well as systemic steroids. Systemic steroids can be given either orally or by injection. One last option can be a biologic. Biologics are large proteins that cannot be absorbed in the stomach. They are derived from living sources such as humans or animals, and they must be injected underneath the skin, a subcutaneous injection, to work, and DUPIXENT is an example of a biologic. Your healthcare provider is your best resource for information about treatment and should be your primary source of contact throughout your eczema journey.

Atopic dermatitis is an inflammatory skin condition, so the idea is “help heal your skin from within.” Next, we're going to talk about DUPIXENT.

DUPIXENT is a prescription medicine used to treat people 12 years and older with moderate-to-severe atopic dermatitis, or eczema, that is not well-controlled with prescription therapies used on the skin (topical medications), or who cannot use those topical therapies. DUPIXENT is a medicine that is a biologic that is taken twice a month, and it is injected underneath the skin. DUPIXENT is not a steroid, and it is not an immuno-suppressant. DUPIXENT can be used with or without your topical therapies.

Atopic dermatitis patients can experience rashes, and also, they have skin that does not actively have rash, so, as you can see from the picture, you have areas of the skin, the arm that has rash, and then the other arm actually does not have a rash. Both areas have inflammation under the skin, so even in the non-flared areas there is still inflammation under the skin of people with atopic dermatitis.

There are two main areas that are involved in atopic dermatitis, the first being a weakened skin barrier. Normal skin is protective and has a very tight barrier, so things can't get in. People with atopic dermatitis have a weak barrier, which causes things like allergens, irritants, bacteria to penetrate that skin. Also, people with atopic dermatitis have an exaggeration of an immune response to those substances, so once those substances are able to get through the dry, cracked skin, they have an excessive inflammatory response that continues even when those substances are not present.

Even when those substances are no longer present, your immune system still overreacts to them. Cytokines, which are small proteins that communicate between cells, are inflamed and continue to have that excess inflammation even when those substances are not present.

When DUPIXENT attaches to certain immune cells, it's able to interrupt that signal and therefore contribute to a decreased inflammation in patients with atopic dermatitis. By reducing inflammation inside the body, DUPIXENT may help reduce symptoms of eczema and make skin noticeably clearer. DUPIXENT works from inside and is the first treatment of its kind that can help manage eczema over time.

With DUPIXENT, you can see and feel the change. What you need to know about DUPIXENT's clinical trials: DUPIXENT was studied in three clinical trials with over 2,100 adults with moderate-to-severe uncontrolled atopic dermatitis. This is the largest clinical development program to date of its kind to treat moderate-to-severe atopic dermatitis patients.

Let's look a little deeper at the studies for atopic dermatitis with DUPIXENT. Of those uncontrolled moderate-to-severe patients, 52% of those patients had moderate atopic dermatitis that enrolled in the study. 48% had severe atopic dermatitis. The average age for those that enrolled was 38. The average duration of disease was 28 years. And we always look at body surface area when we describe rashes. The average body surface area for those that were in these studies was 55%.

In two 16-week adult clinical trials with DUPIXENT when used compared to placebo, which is an inactive substance, nearly half of the adult patients saw a 75% improvement in their skin, whereas some even saw a 90% improvement in their skin. Almost four times more adult patients taking DUPIXENT saw their skin clear or almost clear compared to placebo. Adult patients experienced significant itch reduction, some as early as two weeks in the clinical trials. The most common side effects include injection site reactions; eye and eyelid inflammation, including redness, swelling and itching; and cold sores in your mouth or on your lips.

So, results with DUPIXENT when used alone – so, these patients did not use their topical therapies – compared to placebo, an inactive ingredient, 37% of adult patients had clear or almost clear skin in a 16-week study. 48% of adults showed a 75% improvement in their skin, and 33% of adults had a 90% improvement in their skin on DUPIXENT compared to placebo.

The previous data that we just went over was when DUPIXENT was used alone, so those patients did not use any topical corticosteroids. The data we're going to go over in a moment is those trials that used DUPIXENT with topical corticosteroids versus placebo with topical corticosteroids. 39% of adult patients had clear or almost clear skin, 69% of adult patients had 75% improvement in their skin, and 40% of patients had 90% improvement in their skin.

Adult patients also experienced a significant itch reduction while participating in these clinical trials. 38% of adults in the clinical trial when DUPIXENT was used alone had a significant decreased itch at 16 weeks. 59% percent of those in the trial when DUPIXENT was allowed to be used with topical steroids had a significant decrease in itch.

So, when we look at the results for DUPIXENT at one year with the use of topical corticosteroids compared to placebo with topical corticosteroids, 36% of adult patients have clear or almost clear skin, 65% of those adult patients have 75% improvement in their skin, and 51% of those patients at one year had a significant itch reduction.

So, don't let moderate-to-severe atopic dermatitis hold you back. If you are an adult living with uncontrolled moderate-to-severe eczema or atopic dermatitis, talk to your doctor and see if DUPIXENT is right for you.

There is Important Safety Information you need to know when considering DUPIXENT as a treatment option for your moderate-to-severe atopic dermatitis.

DUPIXENT can cause serious side effects, including allergic reactions; hypersensitivity, including a severe reaction known as anaphylaxis. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you have any of the following symptoms: breathing problem, fever, general ill feeling, swollen lymph nodes, swelling of the face, mouth and tongue, hives, itching, fainting, dizziness, feeling lightheaded, low blood pressure, joint pain or skin rash. DUPIXENT may cause eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision.

The most common side effects include injection site reactions; eye and eyelid inflammation, including redness, swelling and itching; and cold sores in your mouth or on your lips.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed. DUPIXENT is given as an injection under the skin, a subcutaneous injection. If your healthcare provider decides that you or a caregiver can give DUPIXENT injections, you or your caregiver should receive training on the right way to prepare and inject DUPIXENT. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider. In children 12 years of age and older, it is recommended that DUPIXENT be administered by or under the supervision of an adult.

How DUPIXENT is taken and what you need to know about injecting DUPIXENT: DUPIXENT is an injection that is injected subcutaneously right underneath the skin. Talk to your healthcare provider and see the detailed instructions for use that comes with DUPIXENT for information on how to prepare and inject DUPIXENT and how to properly store and throw away DUPIXENT used pre-filled syringes.

DUPIXENT comes in pre-filled syringes, and your healthcare provider will instruct you how to inject these syringes. The very first dose of DUPIXENT is given as a loading dose, meaning it is actually two syringes. After the loading dose, every two weeks, you self-inject one syringe. Patients are able to use DUPIXENT with their topical corticosteroids. To view a short and informative video on injecting DUPIXENT, go to DUPIXENT.com.

Thank you for listening, and I'll be back for a question-and-answer session later on.

(Applause)

SCOTT CORBIN:

Thank you so much, Kate. Really appreciate it. Very, very informative.

It's important to build a health care team that has experience in treating moderate-to-severe atopic dermatitis or eczema.

These teams could include a dermatologist that treats skin disease, or these teams may include an allergist who treats allergic disease. You can use a tool on DUPIXENT.com to help find a specialist with experience in treating eczema in your area. Use the tool by going to DUPIXENT.com and putting in your city and state, and it’ll take you to an independent web site with a list of specific individuals in your area that treat moderate-to-severe atopic dermatitis or eczema. I do want to make sure that you're aware that Regeneron and Sanofi do not specifically endorse any particular provider and that the list that you will be given is not a comprehensive list.

Communicating with your health care team is also vitally important. It's important for you to create and maintain a good relationship with a health care team. It's important for you to ask for information about any outcomes or serious and common side effects of any treatment options, and the Doctor Discussion Guide can help you with that. The Doctor Discussion Guide can be found on DUPIXENT.com. It can help you start that conversation with your health care provider about whether DUPIXENT may or may not be appropriate for you.

Next, I have the distinct honor to introduce Jim Stevenson. Jim Stevenson is a field access specialist. And he's here to discuss the tools and resources for the DUPIXENT MyWay program. So, thank you, Jim.

JIM STEVENSON:

Thanks. Hello, I'm Jim Stevenson, Field Access Specialist for DUPIXENT and DUPIXENT MyWay. I'd like to go over an overview of the DUPIXENT MyWay programs that are available to you and your healthcare provider.

Once you're enrolled in the DUPIXENT MyWay program, you have your own personalized nurse 24 hours a day, 7 days a week, where you can call and ask questions about your DUPIXENT. They'll also work on your benefits, giving you up to dates where we are with your insurance and try to get to DUPIXENT to you as soon as possible. Some additional things that you can find at DUPIXENT MyWay is supplemental injection training, where you can call and talk through with a nurse once you get your DUPIXENT, and another thing they can also do is they can schedule a nurse to actually come out to your home and talk you through the injection.

With DUPIXENT, it is an injectable, and it’s a specialty medication, so most likely your insurance is going to require it to be shipped from specialty pharmacy, although some retail pharmacies may be able to provide it to you. The specialty pharmacies are equipped to work with you to set up shipment and also work with your healthcare provider on the shipment. They can pack it safely into a cooler, and it will arrive right at your door.

With DUPIXENT MyWay, you can also enroll in a DUPIXENT MyWay Copay Card program. What's nice about this program is it offers up to $13,000 a year to help you on your out-of-pocket costs, and that potentially could offer you a zero-dollar copay monthly for your DUPIXENT. There are some criteria that you have to meet. You have to be commercially insured. Those who qualify must be 18 years of age or older, live in the United States, Puerto Rico or Washington D.C., and demonstrate a financial need with a total annualized adjusted gross income of $100,000 or less.

DUPIXENT must also be prescribed for an FDA-approved indication. This is not insurance, not valid for prescriptions paid in whole or part by any type of government program, including Medicare, Medicaid, VA, DOD, TRICARE, or any other state or federal program.

The copay card can help you if you're commercially insured. There's other programs we have like the Patient Assistance Program. With the Patient Assistance Program, if you do not have prescription coverage or your insurance will not cover DUPIXENT, you may be able to get DUPIXENT free of charge. You'd have to meet some criteria with this program. Similar to the copay card, you'd also have to have an FDA-approved prescription from your physician. You'd also have to be a resident of the United States, Puerto Rico or Washington, D.C., and there's some income guidelines to it. You'd have to have a household income of $100,000 or less to possibly be eligible.

There are several different ways where you can enroll in DUPIXENT MyWay email support. You can go online to mywaysupport.com, and with this program, you can opt into email notifications. They will talk about DUPIXENT and the programs that we offer. You can also call 1-844-DUPIXENT, and you can opt-in with one of the specialists at DUPIXENT MyWay.

With all that DUPIXENT MyWay offers and the advice they can give you and covering the questions you may have, the most important thing is that you ask your doctor if you have any additional questions about DUPIXENT or your uncontrolled moderate-to-severe eczema.

So, that’s the overview of DUPIXENT MyWay. Thank you very much for your time. I look forward to talking to any of you afterwards if you have any additional questions.

(Applause)

SCOTT CORBIN:

Thank you, Jim. Thank you again, Jim.

Today, you are actually going to hear from a DUPIXENT MyWay Patient Ambassador. She's going to share her story about living with moderate-to-severe atopic dermatitis, including being on DUPIXENT (dupilumab). Your experience may be different. Without further ado, please welcome Jennifer.

JENNIFER W.:

Hi. I would first like to start by thanking Regeneron and Sanofi Genzyme for sponsoring me to be here today to share my story about life with moderate-to-severe atopic dermatitis and my treatment with DUPIXENT. Of course, we know everybody else's experience may be different.

I knew at age five that I wanted to be a nurse. My afternoons were spent playing with my younger sister and dressing up our cranky old tabby cat, Tiger, who would often need a trip to the hospital for some bandages. Cue Nurse Jenny.

Around this time, I was also diagnosed with eczema. My mother had noticed patches of dry red skin on my elbows and knees from the time I was an infant, but she was reassured that this is fairly common in infants and that I would outgrow it. By age five, these areas persisted, so my mom decided it was time to do something about them. We now had a diagnosis and some cream for Nurse Jenny to apply to the affected areas.

By the time I was a teenager, my skin was getting worse. As if being a 90 lb. string bean of a girl with pale skin, freckles, an overbite, and a very unfortunate haircut wasn't enough, the universe decided to throw in cracking, peeling skin just to make things more interesting.

I grew up in central Florida, where lounging by the pool in your bathing suit was an everyday occurrence, but I would hide over in the shade in an oversized t-shirt and a sweatshirt to cover my skin. The more material the better.

I developed a crush on a certain boy in my grade. He had the most amazing tan, unlike my pale, dry skin. He sat across from me in band, where he played the saxophone, and I couldn't wait to see him every day at second period just so I could look at him. I heard him talking to his friends one day after school about my skin. I can still hear their voices to this day.

I decided to put my head down and focus on becoming a nurse. I took every advanced science class that I could. I particularly loved anatomy, where we were paired up to do dissections. As much as I enjoyed the hands-on learning, I was distracted by the itching that the chemicals brought to my skin. At the end of each class, I would scratch my arms until they bled.

I saw a dermatologist for the first time when I was 16. My mother thought it would be a good idea to see a specialist who might have some better ideas for managing my skin. Up until this point I had only used over-the-counter hydro-cortisone cream and petroleum jelly.

Homecoming was coming up, and I was desperate for anything that would clear up my skin. The oral steroids that I was prescribed helped me to get through homecoming and marked the beginning of my search for treatment options that might work for me.

After jumping through all the hoops to be accepted into nursing school. I also had to provide a waiver from my physician for my atopic dermatitis. I had to wear white cotton gloves underneath my latex exam gloves, and my sleeves had to cover my arm all the way down to my wrist. Still, I was willing to do whatever it took to get through the nursing program. On our first day of clinicals, I had to sing "Happy Birthday" three times while rubbing my dry, raw hands all the way down to my wrist. As soon as my instructor checked me off, I ran to the bathroom to cry and to apply moisturizer for the umpteenth time that day. I never studied as hard as I did in nursing school. I learned more than I thought the human brain could possibly retain, yet during those four years of learning, I never once learned about the most common form of atopic dermatitis, or eczema. Sure, we learned about the layers of the skin and the pathophysiology of skin cancer, and some symptoms of atopic dermatitis.

It wasn't until I was in my mid-thirties and a married mother of five children that I fully understood the underlying inflammation that was partially causing my flares.

Even when my skin looks clear, the inflammation lies beneath the surface, just waiting to be triggered, and I don't think I'm alone in the lack of understanding about atopic dermatitis. It's my hope that more people will understand and be educated about this disease and to stop thinking of it as just eczema.

I met my husband the summer before my senior year of high school, and we got married two years after I graduated, but you won't find any wedding pictures of us in our house. I don't want to be reminded of how bad my skin looked. There's a box of wedding pictures in the back of his closet, and they just stay there, and I don't look at them. After graduating from nursing school I was fortunate enough to get a job in the area of nursing that I feel the most passionate about, women's health. I was going to be a labor and delivery nurse.

Around this time my husband and I had a four-year-old daughter, a two-year-old son and baby number three on the way. I was seeing a dermatologist again, and it seemed like I was trying a different prescription topical cream every month. I tried PUVA treatments three days a week before work for six months. I tried eliminating foods from my diet. My dermatologist finally gave up and sent me to a prestigious clinic. After a week of testing I came home with a 66-page report of common and not-so-common ingredients found in soaps, cleansers and lotions that I was to avoid and a very short list of things that were okay for me to use. There was literally one laundry soap that was safe for me to use, and of course, it wasn't something found in our local stores. I was having my preservative-free daily moisturizer compounded and shipped to me.

I was doing bleach baths three days a week. This went on for a year or more. My hands were so raw and swollen, I was physically unable to bend them. Can you imagine a labor and delivery nurse trying to start your IV or holding your brand-new beautiful baby with hands that look like they belong to a monster? I worked in that small community hospital for 10 years before finally having my big break.

I was recruited to join the management team for a women's health unit at a brand-new hospital. Finally, somebody saw my potential! Shortly after arriving at my new hospital, an old high school friend reached out to me on social media. She had gone to medical school and was now practicing as an eczema specialist in our area. She said she remembered my struggles with my skin throughout high school, and she was curious to know how I was doing, so I made an appointment to meet with her, and she's now been treating me for the past few years.

Two years ago my specialist mentioned a new medication that she thought I should try called DUPIXENT. I'll admit I was skeptical. For most of my life, people had been telling me about this or that cream or lotion or pill that helped their brother or their great uncle or their brother's goldfish. Honestly, is there anybody here with eczema who hasn't been offered some unsolicited advice about how to fix your skin?

There were days, weeks, months, even years when it was hard to recognize who I was. It was almost impossible to see past the redness and the weeping, past the broken skin, the cracks and the scratches. There were days when the cold winter air would irritate my face and nights when my face would stick to my pillow because my skin was oozing and weeping onto the pillowcase, so, yes, I was a little skeptical and a little worried to try something new.

What were my worries? That it wouldn't work. My specialist had told me about the benefits and the potential risks, including the serious and common side effects. She told me to let her know immediately and to see an eye doctor right away if I developed conjunctivitis, but I talked things over with my husband, who is amazing, by the way, and he reminded me that I'd already been to hell and back.

He had a point, so after thinking it over for a few months and reading through the information from my specialist, I agreed to try DUPIXENT.

My specialist also gave me some information on a program called DUPIXENT MyWay that might help cover some of my copays. She had her office staff call in the prescription, and the very next day, DUPIXENT MyWay contacted me and answered all my questions about their copay program. They asked me some questions about my insurance to see if I qualified. Of course, everybody's insurance situation is a little different, but I was relieved to find out that I qualified.

The pharmacy then called me to get my address and to find out if I needed any supplies like alcohol wipes or a sharps container to dispose of my syringes. Next came the injection training. Now, by this point I had been a nurse for about 12 years. In nursing school, we were first taught how to do injections by practicing on hotdogs, of all things, and I often give injections to squirming newborns with worrying parents hovering over my shoulder, so I figured, "I've got this."

I was a little surprised to find that I could still benefit from some training on giving myself injections from my physician. She provided this training on the proper way to inject DUPIXENT under my skin and to rotate the injection site with each injection. First, I noticed some small changes in my symptoms. Within weeks my skin became clearer. I only had one small patch of dry skin on my wrist. I texted my specialist to tell her how happy I was with the treatment and that I couldn't believe how clear my skin was.

As a nurse, I am an advocate for my patients. That's what I do. As someone with moderate-to-severe atopic dermatitis, I'm my own advocate. It was up to me to speak up when I didn't feel like my treatment was working. It was up to me to ask questions and to request more information.

I wanted to see a change in my skin, and I knew I was the one who had to take the next steps. I knew there must be something out there, and it was up to me to keep on searching. If I could somehow impart some words of wisdom to five-year-old Nurse Jenny, I would tell her that the road is long, but the years are short. Moderate-to-severe atopic dermatitis is not who you are but what you might overcome. Thank you for being here today and for being such a great audience.

(Applause)

SCOTT CORBIN:

Thank you so much. Thank you so much, Jennifer. We appreciate you being willing to share your story. Thank you for being so brave.

JENNIFER W.:

My pleasure.

SCOTT CORBIN:

We're going to be back in a few minutes to answer all your questions, but for more inspiring stories please check out DUPIXENT.com.

(Dip to black)

SCOTT CORBIN:

Welcome back. We've reached the Question-and-Answer session of our program today. So, are there any questions out there?

AUDIENCE MEMBER #1:

Can you explain the difference between eczema and atopic dermatitis again, please?

SCOTT CORBIN:

Thank you for that question. Dr. Sowerwine, would you mind taking that?

DR. KATE SOWERINE:

Sure. I'd be happy to take that. So, atopic dermatitis is a form of eczema. Eczema is an umbrella term that encompasses many different types of rashes. Atopic dermatitis is the most common form of eczema. Atopic dermatitis is a chronic inflammation under the skin.

SCOTT CORBIN:

Thank you, Dr. Sowerwine.

DR. KATE SOWERINE:

No problem.

SCOTT CORBIN:

Any other questions?

AUDIENCE MEMBER #2:

How do you and your doctor know if DUPIXENT may be an option for you?

SCOTT CORBIN:

Thank you for that question. Dr. Sowerwine, would you mind taking that question, please?

DR. KATE SOWERINE:

Sure. I can definitely take that. Your healthcare team will determine if you are a good candidate for DUPIXENT. I recommend writing down your experiences and taking that with you to your healthcare appointment. There is also a discussion guide on DUPIXENT.com that can help facilitate that discussion.

SCOTT CORBIN:

What other questions do we have? Yes.

AUDIENCE MEMBER #3:

How do I fill a prescription for DUPIXENT?

SCOTT CORBIN:

Thank you for that question. Jim, would you mind taking her question, please?

JIM STEVENSON:

Oh, great. Thanks. Great question. So, DUPIXENT is an injectable medication, and it does require a special shipping and handling. The specialty pharmacies are best equipped to coordinate with you and your healthcare professional to coordinate shipping and also to package it in a special cooler, and they'll ship it right to your home.

SCOTT CORBIN:

Thank you for your question. What other questions do we have? Yes?

AUDIENCE MEMBER #4:

I have a question for the Patient Ambassador. What kind of training or support did you have to begin self-injecting?

JENNIFER W.:

So, as a nurse I am trained to give injections to others. So, injecting myself is a little something, a little something different altogether. It was very helpful to receive training from my doctor, who went over how and where to inject. She then watched me administer the medication to myself and provided feedback.

SCOTT CORBIN:

Thank you, Jennifer. Other questions?

AUDIENCE MEMBER #5:

I know the doctor talked about it earlier, but can you explain more about eyelid and eyelid reactions?

SCOTT CORBIN:

Thank you. Dr. Sowerwine?

DR. KATE SOWERWINE:

Sure. I'll take that. One of the most common side effects in those with atopic dermatitis is eye and eyelid inflammation. So, any itching, burning or pain is very important to discuss with your healthcare provider. Conjunctivitis is the most common eye problem reported with DUPIXENT. It's very important to discuss any new or worsening eye problems with your physician, especially any pain in the eye or change in vision. Additional common side effects include injection site reactions and cold sores in your mouth or on your lips. Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

SCOTT CORBIN:

Thank you, Dr. Sowerwine. What other questions do we have? Yes.

AUDIENCE MEMBER #6:

How much does DUPIXENT cost?

SCOTT CORBIN:

Great question. Jim, would you mind?

JIM STEVENSON:

No. Thank you for the question. So, there's a number of factors that come into play on how much your out-of-pocket costs will be for DUPIXENT. One is do you have a prescription drug coverage.

What type of insurance that you have. Is DUPIXENT preferred or non-preferred? And also, have you met your deductible? So, you can actually have two individuals that might have different amounts on their out-of-pocket because of all these factors. So, the best way to find out how much DUPIXENT will cost you is to call your insurance provider, and they'll give you all the details on your out-of-pocket.

AUDIENCE MEMBER #6:

What if I change insurance companies while I am on DUPIXENT?

JIM STEVENSON:

That's another common question. If you do change insurances, you want to make sure that you let your healthcare provider know right away and also your specialty pharmacy because there might be some additional paperwork that's going to need to be completed. We want to make sure that you don't miss a dose of your DUPIXENT, and if you have any further questions, just make sure, you can always reach out 1-844-DUPIXENT.

SCOTT CORBIN:

What other questions do we have? Yes.

AUDIENCE MEMBER #7:

This question is for the Patient Ambassador. How long have you been receiving DUPIXENT and when did you start to notice a difference?

JENNIFER W.:

So, I first started taking DUPIXENT in September of 2017. At first, I noticed small changes in my skin, and within a few weeks, I had much clearer skin. Of course, this is my personal experience and everyone else's maybe a little bit different.

SCOTT CORBIN:

Thank you, Jennifer. I just want to thank you, again, for being so brave and talking with us and giving us your story. Jim, thank you so much for your information, as well, and Dr. Sowerwine, thank you so much for educating us today. But last but not least is certainly thank you to everyone here. We really appreciate your participation and your willingness for this DUPIXENT MyWayDUPIXENT MyWay program discussion.

And after today's informative discussion, we really hope that you'll be even more informed, even more inspired, and starting today, you'll be more of an active participant in your healthcare team and be a patient advocate for yourself.

For additional questions please be sure to talk to your healthcare provider or visit DUPIXENT.com. Thank you again for your time. Have a great rest of the day!

Here’s what you’ll learn

Get more information on:

  • Uncontrolled moderate-to-severe atopic dermatitis from an eczema specialist
  • DUPIXENT as a potential treatment option for uncontrolled moderate-to-severe atopic dermatitis
  • Additional resources from the DUPIXENT MyWay program
  • Hear from a DUPIXENT MyWay ambassador and their story about living with moderate-to-severe atopic dermatitis and their experience with DUPIXENT

Plus, an audience Q&A with the speaker panel.

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