How to Take DUPIXENT

DUPIXENT is Taken By Injection

DUPIXENT is a form of medicine called a biologic, and taken by injection under the skin
(subcutaneous injection). Get information on recommended dosing and proper injection instructions. Also,
hear from patients who have taken advantage of DUPIXENT MyWay® tools and resources.

Once my healthcare team showed me the proper way to give myself an injection, I became more comfortable with the idea of doing it. Now I inject myself once every 2 weeks based upon my doctor’s instructions.

- Sue, DUPIXENT MyWay®
Patient Ambassador

Individual results may vary.

See the Rest of Sue's Story

Recommended Dosing
for DUPIXENT

The recommended dose is specified in the table below. Use DUPIXENT exactly as prescribed by your healthcare provider. Your initial dose of DUPIXENT is 2 injections under the skin (subcutaneous injection) at different injection sites. After that, it is taken as 1 injection at different injection sites every 2 weeks or every 4 weeks, depending on your age and weight. Your healthcare provider will tell you how much DUPIXENT to inject and how often. DUPIXENT can be used with or without topical corticosteroids.

Age/Body Weight
of Patient
Initial Dose Subsequent Dose
Adults 18+
Any weight 600 mg;
two 300‑mg
injections
300 mg
every 2 weeks
Children and Teens
33 lb – 66 lb 600 mg;
two 300‑mg
injections
300 mg
every 4 weeks
67 lb – 132 lb 400 mg;
two 200‑mg
injections
200 mg
every 2 weeks
133 lb or more 600 mg;
two 300‑mg
injections
300 mg
every 2 weeks

Talk to you or your child’s healthcare professional, and download the detailed Instructions for Use for information on how to prepare and inject DUPIXENT and how to properly store and dispose of used DUPIXENT Pre-filled Syringes. Do not try and inject DUPIXENT until you have been shown the right way by your healthcare provider. In teens 12 years of age or older, it is recommended that DUPIXENT be administered by or under the supervision of an adult. DUPIXENT should be given by a caregiver in children 6-11 years of age.

If you or your child’s healthcare provider decides that you or your teen can give the injections of DUPIXENT, you or your teen should receive training on the right way to prepare and inject DUPIXENT.

How to Administer DUPIXENT

Use DUPIXENT exactly as prescribed by your doctor. DUPIXENT is available as a single-dose, pre-filled syringe with needle
shield. DUPIXENT is given as an injection under the skin (subcutaneous injection) into different injection sites. In children 6-11 years of age, DUPIXENT should be administered by a caregiver.

Watch the videos for a supplemental demonstration on how to use and dispose of DUPIXENT.

Self-Injection

Transcript

Hi there. I'm Laura.

Today I'm going to show you how to properly self-inject a dose of DUPIXENT (dupilumab).

You've already learned how to self-inject with your healthcare provider.

I'm here to guide your first at-home experience.

When I first started self-injections, I found syringes really intimidating. I've gotten better at the process since then, so I want to share those steps with you today.

I'll show you what supplies to gather, how to prep the injection area, and how to inject the dose and discard your used syringe.

If you haven't yet read the instructions for use located in your treatment packaging, pause the video and take a look.

I found it helpful to understand the plunger, syringe body, and needle cap before handling the syringe itself.

Contact your healthcare provider or the DUPIXENT MyWay Hotline with any questions.

It's time for me to take my DUPIXENT injection. Feel free to watch me and follow along as I self-inject.

Narration

Take your medication out of the refrigerator. Never freeze your syringe.

Remove the syringe by holding the middle of the syringe body.

  • Do not use the syringe if it has been dropped on a hard surface or is damaged.
  • Do not pull off the needle cap or touch the plunger rod until you are ready to inject.
  • Do not pull back on the plunger rod at any time.
  • Keep DUPIXENT syringes and all medicines out of the reach of children.
  • If you have an unused syringe, return it to the refrigerator in the original carton to protect it from light.

Your DUPIXENT Pre-filled Syringe may appear different than what I am using in this video, based on the prescribed dose. If you have questions about the dosage prescribed to you, please contact your healthcare provider.

Check the label to make sure the medication inside is correct and the expiration date has not passed. If it isn't right, contact your pharmacy.

You may see an air bubble, this is normal. Do not try to get rid of any air bubbles.

The liquid inside should be clear and colorless to pale yellow.

Do not use the syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles. Throw away (dispose of) the used DUPIXENT single-dose pre-filled syringe right away after use.

If you have any questions about whether the syringe is OK to use, please call the DUPIXENT MyWay Hotline or your healthcare provider.

Lay the syringe on a flat surface and let it naturally warm to room temperature.

The recommended warming time for the 200 mg syringe is 30 minutes, and for the 300 mg syringe, it's 45 minutes.

  • Do not heat the syringe.
  • Do not put the syringe into direct sunlight.
  • Do not keep DUPIXENT at room temperature for more than 14 days. Throw away (dispose of) any syringe that has been left at room temperature for longer than 14 days.
  • Do not shake the syringe.

While you wait, gather the additional materials necessary to self-inject.

You need one cotton ball or gauze, one alcohol wipe, and a puncture-resistant Sharps Disposal Container.

If you don't have a Sharps Disposal Container, call a DUPIXENT MyWay representative to request a complimentary Sharps Disposal Container.

Now, take your supplies to an area where you can sit comfortably.

When you are ready to get started, wash your hands thoroughly.

Choose your injection site. Both the stomach and thigh are acceptable, except for the two inches around your belly button.

If a caregiver gives you the injection, the outer area of the upper arm is also an option. The person giving the injection should follow the same preparation procedure.

Be sure to choose a different site each time you inject DUPIXENT.

  • Do not inject through clothes.
  • Do not inject into skin that is tender, damaged, or is bruised or scarred.

Clean your skin with the alcohol wipe.

Do not touch the injection site again or blow on it before the injection. Let your skin dry before injection.

Hold the DUPIXENT syringe in the middle of the Syringe Body with the Needle pointing away from you and carefully remove the cap from the syringe.

  • Do not use if the needle cap is missing or not securely attached.
  • Do not put the needle cap back on.
  • Do not touch the needle. Inject the medicine right away after removing the Needle cap.

Pinch a fold of skin at the injection site. Pinching your skin helps the medicine go into a fatty layer, just below the skin, and not into the muscle.

Take a deep breath.

Continue to pinch as you insert the needle completely at about a 45° angle.

Relax your pinch.

Push the plunger down slowly and steadily as far as it will go, until the syringe is empty.

You will feel some resistance. This is normal.

Lift your thumb to release the Plunger Rod until the Needle is covered by the Needle Shield, and then remove the Syringe from the injection site.

Lightly press a cotton ball or gauze on the injection site if you see any blood. Do not put the needle cap back on.

Do not rub your skin after the injection.

You can also cover the site with a bandage.

Put your used Needles, DUPIXENT Syringes, and Needle Caps in an FDA-cleared Sharps Disposal Container right away after Use.

Do not dispose of needles, DUPIXENT Syringes, and Needle Caps in your household trash.

Follow your local guidelines, and ask your healthcare provider for the appropriate way to dispose of the container once it is full.

Do not recycle your used Sharps Disposal Container.

Do not reuse the syringe.

If you would like to practice before doing the actual injection and you have received the DUPIXENT training kit from your doctor's office, you can practice the 45° injection angle with your training syringe and the angle aid, and you could always watch the video again.

Remember, do not use the angle aid to administer an actual injection.

Narration - On Camera Ending

Be sure to keep track of your injection date and site.

Thank you for joining me today. Remember, you can rewatch this video as often as you like to refresh your memory.

Contact your healthcare provider or the DUPIXENT MyWay Hotline with any questions or concerns.

Narration - ISI Indication

Important Safety Information
and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have eye problems
  • have a parasitic (helminth) infection
  • are scheduled to receive any vaccinations. You should not receive a "live vaccine" if you are treated with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
    • There is a pregnancy exposure registry for women who take DUPIXENT during pregnancy to collect information about the health of you and your baby. Your healthcare provider can enroll you or you may enroll yourself. To get more information about the registry call
      1-877-311-8972 or go to https://mothertobaby.org/ongoing-study/dupixent/.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical or inhaled corticosteroid medicines or if you have atopic dermatitis and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions (hypersensitivity), including a severe reaction known as anaphylaxis. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following symptoms: breathing problems, fever, general ill feeling, swollen lymph nodes, swelling of the face, mouth and tongue, hives, itching, fainting, dizziness, feeling lightheaded (low blood pressure), joint pain, or skin rash.
  • Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision.

The most common side effects in patients with atopic dermatitis include injection site reactions, eye and eyelid inflammation, including redness, swelling and itching, and cold sores in your mouth or on your lips.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call
1-800-FDA-1088.

Use DUPIXENT exactly as prescribed. Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it. DUPIXENT is an injection given under the skin (subcutaneous injection). If your healthcare provider decides that you or a caregiver can give DUPIXENT injections, you or your caregiver should receive training on the right way to prepare and inject DUPIXENT. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider. In children 12 years of age and older, it is recommended that DUPIXENT be administered by or under supervision of an adult. In children younger than 12 years of age, DUPIXENT should be given by a caregiver.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used to treat people aged 6 years and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.

Caregiver Injection

Transcript

MOM: Since you’re watching this video, I know you’ve already learned how to give an injection with your healthcare provider. I’m just here to help guide you through your first at-home experience.

When I first started giving injections, I found syringes really intimidating. I've gotten better at the process since then, so I wanted to share those steps with you today.

If you haven’t yet read the Instructions for Use located in your treatment packaging, pause the video and take a look. And if you have any questions along the way, don’t hesitate to reach out to your healthcare provider or the DUPIXENT MyWay hotline. They’re always there to help.

MOM: Are you ready? …OK

Are you ready?

SON: What?

MOM: Let’s show them how to properly inject a dose of DUPIXENT.

SON: Oh, sure.

MOM: First, take your medication out of the refrigerator. Never freeze your syringe.

Remove the syringe by holding the middle of the syringe body.

A few things to remember:

  • Do not use the syringe if it has been dropped on a hard surface or is damaged.
  • Do not pull off the needle cap or touch the plunger rod until you are ready to inject.
  • Do not pull back on the plunger rod at any time.
  • Keep DUPIXENT syringes and all medicines out of the reach of children.
  • If you have an unused syringe, return it to the refrigerator in the original carton to protect it from light.

Your DUPIXENT pre-filled syringe may appear different from what you see in this video, based on the prescribed dose. If you have questions about the dosage prescribed, please contact your healthcare provider.

OK, now it’s time to check the label to make sure the medication and dosage are correct and the expiration date has not passed. If it isn’t right, contact your pharmacy.

SON: Looks right to me.

MOM: Yup.

Now look at the medicine through the Viewing Window on the DUPIXENT syringe. The liquid inside should be clear and colorless to pale yellow. You may see an air bubble; this is normal. Do not try to get rid of any air bubbles.

Do not use the syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles. Throw away, dispose of, the used DUPIXENT single-dose pre-filled syringe right away after use.

If you have any questions about whether the syringe is okay to use, please call the DUPIXENT MyWay hotline, or your healthcare provider.

Lay the syringe on a flat surface and let it naturally warm to room temperature.

The recommended warming time for the 200mg syringe is 30 minutes, and for the 300mg syringe, it's 45 minutes.

Here are a few more things to remember:

  • Do not heat the syringe.
  • Do not put the syringe into direct sunlight.
  • Do not keep DUPIXENT at room temperature for more than 14 days. Throw away any syringe that has been left at room temperature for longer than 14 days.
  • Do not shake the syringe.

While you wait, gather the additional necessary materials.

You need one cotton ball or gauze.

SON: Check.

MOM: One alcohol wipe.

SON: Check.

MOM: And a puncture-resistant sharps disposal container.

SON: Check.

MOM: If you don’t have a sharps disposal container, call a DUPIXENT MyWay representative to request a complimentary sharps disposal container.

When you are ready to get started, wash your hands thoroughly.

Now, take your supplies to an area where you can sit comfortably.

Choose your injection site. Both the stomach and thigh are acceptable, except for the two inches around the belly button. The outer area of the upper arm is also an option since you are giving the injection to someone, but not if you’re self-injecting.

Be sure to choose a different site each time you inject DUPIXENT.

  • Do not inject through clothes.
  • Do not inject into skin that is tender, damaged, bruised, or scarred.

OK, now clean the skin with the alcohol wipe.

Do not touch the injection site again or blow on it before the injection.

Once the skin is dry, hold the DUPIXENT syringe in the middle of the syringe body with the needle pointing away from you and carefully remove the cap from the syringe.

  • Do not use if the needle cap is missing or not securely attached.
  • Do not put the needle cap back on.
  • Do not touch the needle. Inject the medicine right away after removing the needle cap.

Pinch a fold of skin at the injection site. Pinching the skin helps the medicine go into a fatty layer, just below the skin, and not into the muscle.

Take a deep breath.

Continue to pinch as you insert the needle completely at about a 45° angle.

Relax your pinch.

Push the plunger down slowly and steadily as far as it will go, until the syringe is empty. You will feel some resistance. This is normal.

Lift your thumb to release the plunger rod until the needle is covered by the needle shield and then remove the syringe from the injection site.

Lightly press a cotton ball or gauze on the injection site if you see any blood. Do not put the needle cap back on, and do not rub the skin after the injection.

SON: Got it.

MOM: You can also cover the site with a bandage.

OK, now put the used DUPIXENT syringe and cap in an FDA-cleared sharps disposal container right away after use.

Do not put DUPIXENT syringes in your household trash. Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once it is full.

Do not recycle your used sharps disposal container. And do not reuse the syringe.

If you would like to practice before doing the actual injection and you have received the DUPIXENT training kit from your doctor's office, you can practice the 45° injection angle with the training syringe and the angle aid. Do not use the angle aid to administer an actual injection.

Finally, always be sure to keep track of the injection date and site.

Well, now you know how to give a dose of DUPIXENT. If you follow these steps, you’ll be a pro in no time.

Feel free to rewatch this video as many times as you’d like. And again, reach out to your healthcare provider or call the DUPIXENT MyWay hotline if you have any questions.

Well, that wasn’t so bad, was it?

SON: What?

Important Safety Information
and Indications

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have eye problems
  • have a parasitic (helminth) infection
  • are scheduled to receive any vaccinations. You should not receive a "live vaccine" if you are treated with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
    • There is a pregnancy exposure registry for women who take DUPIXENT during pregnancy to collect information about the health of you and your baby. Your healthcare provider can enroll you or you may enroll yourself. To get more information about the registry call
      1-877-311-8972 or go to https://mothertobaby.org/ongoing-study/dupixent/.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines; have asthma and use an asthma medicine; or have atopic dermatitis or CRSwNP, and also have asthma. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions (hypersensitivity), including a severe reaction known as anaphylaxis. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following symptoms: breathing problems, fever, general ill feeling, swollen lymph nodes, swelling of the face, mouth and tongue, hives, itching, fainting, dizziness, feeling lightheaded (low blood pressure), joint pain, or skin rash.
  • Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision.
  • Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, shortness of breath, persistent fever, chest pain, or a feeling of pins and needles or numbness of your arms or legs.

The most common side effects include:

  • Atopic dermatitis: injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, and cold sores in your mouth or on your lips.
  • Asthma: injection site reactions, pain in the throat (oropharyngeal pain), and high count of a certain white blood cell (eosinophilia).

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call
1-800-FDA-1088.

Use DUPIXENT exactly as prescribed. Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it. DUPIXENT is an injection given under the skin (subcutaneous injection). If your healthcare provider decides that you or a caregiver can give DUPIXENT injections, you or your caregiver should receive training on the right way to prepare and inject DUPIXENT. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider. In children 12 years of age and older, it is recommended that DUPIXENT be administered by or under supervision of an adult. In children younger than 12 years of age, DUPIXENT should be given by a caregiver.

Please see accompanying full Prescribing Information including Patient Information.

Indications

DUPIXENT is a prescription medicine used:

  • to treat people aged 6 years and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.
  • with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in people aged 12 years and older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems. It is not known if DUPIXENT is safe and effective in children with asthma under 12 years of age.

Share Your Story

Your experience with DUPIXENT is unique and yours to tell, and we want to know your story. It can inspire people going through similar experiences. If selected, you may be featured in print materials, on social media, or in videos.

Interested in hearing more or sharing your story?
Call 1‑844‑DUPIXENT, option 5
(1‑844‑387‑4936)