How to Take DUPIXENT

DUPIXENT is Taken By Injection

DUPIXENT is a form of medicine called a biologic, and taken by injection under the skin
(subcutaneous). Get information on recommended dosing, proper injection instructions,
and hear from patients who took advantage of DUPIXENT MyWay® tools and resources.

Once my healthcare team showed me the proper way to give myself an injection, I became more comfortable with the idea of doing it. Now I inject myself once every 2 weeks based upon my doctor’s instructions.

- Sue, DUPIXENT MyWay®
Patient Ambassador

Individual results may vary.

See the Rest of Sue's Story

Recommended Dosing

The recommended dose of DUPIXENT is specified in the table below. Use DUPIXENT exactly as prescribed by your healthcare provider.

Body Weight
of Patient
Initial Dose Subsequent Doses
(every other week)
Teens less than
60 kg (132 lbs)
400 mg (two
200 mg injections)
200 mg
All Adults
Teens 60 kg or
more (133 lbs)
600 mg (two
300 mg injections)
300 mg

Your initial dose of DUPIXENT is 2 injections under the
skin (subcutaneous) at different injection sites. After that, it is taken
as 1 injection every other week at different injection sites.
DUPIXENT can be used with or without topical corticosteroids.

How to Administer DUPIXENT

Use DUPIXENT exactly as prescribed by your doctor. DUPIXENT comes as a single-dose, pre-filled syringe with needle
shield. DUPIXENT is given as an injection under the skin (subcutaneous) into different injection sites.

Watch the videos for a supplemental demonstration on how to use and dispose of DUPIXENT.

Self-Injection

Transcript

Hi there. I'm Laura.

Today I'm going to show you how to properly self-inject a dose of DUPIXENT (dupilumab).

You've already learned how to self-inject with your healthcare provider.

I'm here to guide your first at-home experience.

When I first started self-injections, I found syringes really intimidating. I've gotten better at the process since then, so I want to share those steps with you today.

I'll show you: what supplies to gather, how to prep the injection area, and how to inject the dose and discard your used syringe.

If you haven't yet read the instructions for use located in your treatment packaging, pause the video and take a look.

I found it helpful to understand the plunger, syringe body, and needle cap before handling the syringe itself.

Contact your healthcare provider or the DUPIXENT MyWay Hotline with any questions.

It's time for me to take my DUPIXENT injection. Feel free to watch me and follow along as I self-inject.

Narration

Take your medication out of the refrigerator. Never freeze your syringe.

Remove the syringe by holding the middle of the syringe body.

Do not use the syringe if it has been dropped on a hard surface or is damaged.

Do not pull off the needle cap or touch the plunger rod until you are ready to inject.

Do not pull back on the plunger rod at any time.

Keep DUPIXENT syringes and all medicines out of the reach of children.

If you have an unused syringe, return it to the refrigerator in the original carton to protect it from light.

Your DUPIXENT pre-filled syringe may appear different than what I am using in this video, based on the prescribed dose. If you have questions about the dosage prescribed to you, please contact your healthcare provider.

Check the label to make sure the medication inside is correct and the expiration date has not passed. If it isn't right, contact your pharmacy.

You may see an air bubble, this is normal. Do not try to get rid of any air bubbles.

The liquid inside should be clear, and colorless to pale yellow.

Do not use the syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles. Throw away, dispose of, the used DUPIXENT single- dose pre-filled syringe right away after use.

If you have any questions about whether the syringe is okay to use, please call the DUPIXENT MyWay Hotline or your healthcare provider.

Lay the syringe on a flat surface and let it naturally warm to room temperature.

The recommended warming time for the 200mg syringe is 30 minutes, and for the 300mg syringe, it's 45 minutes.

Do not heat the syringe.

Do not put the syringe into direct sunlight.

Do not keep DUPIXENT at room temperature for more than 14 days. Throw away, dispose of, any syringe that has been left at room temperature for longer than 14 days.

Do not shake the syringe.

While you wait, gather the additional materials necessary to self-inject.

You need one cotton ball or gauze, one alcohol wipe, and a puncture resistant Sharps Disposal Container.

If you don't have a Sharps Disposal Container, call a DUPIXENT MyWay representative to request a complimentary Sharps Disposal Container.

Now, take your supplies to an area where you can sit comfortably.

When you are ready to get started, wash your hands thoroughly.

Choose your injection site. Both the stomach and thigh are acceptable, except for the two inches around your belly button.

If a caregiver gives you the injection, the outer area of the upper arm is also an option. The person giving the injection should follow the same preparation procedure.

Be sure to choose a different site each time you inject DUPIXENT.

Do not inject through clothes.

Do not inject into skin that is tender, damaged or is bruised or scarred.

Clean your skin with the alcohol wipe.

Do not touch the injection site again or blow on it before the injection. Let your skin dry before injection.

Hold the DUPIXENT syringe in the middle of the Syringe Body with the Needle pointing away from you and carefully remove the cap from the syringe.

Do not use if the needle cap is missing or not securely attached.

Do not put the needle cap back on.

Do not touch the needle. Inject the medicine right away after removing the Needle cap.

Pinch a fold of skin at the injection site. Pinching your skin helps the medicine go into a fatty layer, just below the skin, and not into the muscle.

Take a deep breath.

Continue to pinch, as you insert the needle completely at about a 45° angle.

Relax your pinch.

Push the plunger down slowly and steadily as far as it will go, until the syringe is empty.

You will feel some resistance. This is normal.

Lift your thumb to release the Plunger Rod until the Needle is covered by the Needle Shield and then remove the Syringe from the injection site.

Lightly press a cotton ball or gauze on the injection site if you see any blood. Do not put the needle cap back on.

Do not rub your skin after the injection.

You can also cover the site with a bandage.

Put your used Needles, DUPIXENT Syringes, and Needle Caps in a FDA-cleared Sharps Disposal Container right away after Use.

Do not dispose of needles, DUPIXENT Syringes, and Needle Caps in your household trash.

Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once it is full.

Do not recycle your used Sharps Disposal Container.

Do not reuse the syringe.

If you would like to practice before doing the actual injection and you have received the DUPIXENT training kit from your doctor's office, you can practice the 45° injection angle with your training syringe and the angle aid, and you could always watch the video again.

Remember, do not use the angle-aid to administer an actual injection.

Narration - On Camera Ending

Be sure to keep track of your injection date and site.

Thank you for joining me today. Remember, you can re-watch this video as often as you like to refresh your memory.

Contact your healthcare provider or the DUPIXENT MyWay Hotline with any questions or concerns.

Narration - ISI Indication

Caregiver Injection

Transcript

MOM: Since you’re watching this video, I know you’ve already learned how to give an injection with your healthcare provider. I’m just here to help guide you through your first at-home experience.

When I first started giving injections, I found syringes really intimidating. I've gotten better at the process since then, so I wanted to share those steps with you today.

If you haven’t yet read the Instructions for Use located in your treatment packaging, pause the video and take a look. And if you have any questions along the way, don’t hesitate to reach out to your healthcare provider or the DUPIXENT MyWay hotline. They’re always there to help.

MOM: Are you ready? …OK

Are you ready?

SON: What?

MOM: Let’s show them how to properly inject a dose of DUPIXENT.

SON: Oh, sure.

MOM: First, take your medication out of the refrigerator. Never freeze your syringe.

Remove the syringe by holding the middle of the syringe body.

A few things to remember:

  • Do not use the syringe if it has been dropped on a hard surface or is damaged.
  • Do not pull off the needle cap or touch the plunger rod until you are ready to inject.
  • Do not pull back on the plunger rod at any time.
  • Keep DUPIXENT syringes and all medicines out of the reach of children.
  • If you have an unused syringe, return it to the refrigerator in the original carton to protect it from light.

Your DUPIXENT pre-filled syringe may appear different from what you see in this video, based on the prescribed dose. If you have questions about the dosage prescribed, please contact your healthcare provider.

OK, now it’s time to check the label to make sure the medication and dosage are correct and the expiration date has not passed. If it isn’t right, contact your pharmacy.

SON: Looks right to me.

MOM: Yup.

Now look at the medicine through the Viewing Window on the DUPIXENT syringe. The liquid inside should be clear and colorless to pale yellow. You may see an air bubble; this is normal. Do not try to get rid of any air bubbles.

Do not use the syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles.

Throw away, dispose of, the used DUPIXENT single-dose, pre-filled syringe right away after use.

If you have any questions about whether the syringe is OK to use, please call the DUPIXENT MyWay hotline, or your healthcare provider.

Lay the syringe on a flat surface and let it naturally warm to room temperature. The recommended warming time for the 200mg syringe is 30 minutes, and for the 300mg syringe it's 45 minutes.

Here are a few more things to remember:

  • Do not heat the syringe.
  • Do not put the syringe into direct sunlight.
  • Do not keep DUPIXENT at room temperature for more than 14 days. Throw away any syringe that has been left at room temperature for longer than 14 days.
  • Do not shake the syringe.

While you wait, gather the additional necessary materials.

You need one cotton ball or gauze.

SON: Check.

MOM: One alcohol wipe.

SON: Check.

MOM: And a puncture-resistant sharps disposal container.

SON: Check.

MOM: If you don’t have a sharps disposal container, call a DUPIXENT MyWay representative to request a complimentary sharps disposal container.

When you are ready to get started, wash your hands thoroughly.

Now, take your supplies to an area where you can sit comfortably.

Choose your injection site. Both the stomach and thigh are acceptable, except for the two inches around the belly button. The outer area of the upper arm is also an option since you are giving the injection to someone, but not if you’re self-injecting.

Be sure to choose a different site each time you inject DUPIXENT.

  • Do not inject through clothes.
  • Do not inject into skin that is tender, damaged, bruised, or scarred.

OK, now clean the skin with the alcohol wipe.

Do not touch the injection site again or blow on it before the injection.

Once the skin is dry, hold the DUPIXENT syringe in the middle of the syringe body with the needle pointing away from you and carefully remove the cap from the syringe.

  • Do not use if the needle cap is missing or not securely attached.
  • Do not put the needle cap back on.
  • Do not touch the needle. Inject the medicine right away after removing the needle cap.

Pinch a fold of skin at the injection site. Pinching the skin helps the medicine go into a fatty layer, just below the skin, and not into the muscle.

Take a deep breath.

Continue to pinch as you insert the needle completely at about a 45° angle.

Relax your pinch.

Push the plunger down slowly and steadily as far as it will go, until the syringe is empty. You will feel some resistance. This is normal.

Lift your thumb to release the plunger rod until the needle is covered by the needle shield and then remove the syringe from the injection site.

Lightly press a cotton ball or gauze on the injection site if you see any blood. Do not put the needle cap back on, and do not rub the skin after the injection.

SON: Got it.

MOM: You can also cover the site with a bandage.

OK, now put the used DUPIXENT syringe and cap in an FDA-cleared sharps disposal container right away after use.

Do not put DUPIXENT syringes in your household trash. Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once it is full.

Do not recycle your used sharps disposal container. And do not reuse the syringe.

If you would like to practice before doing the actual injection and you have received the DUPIXENT training kit from your doctor's office, you can practice the 45° injection angle with the training syringe and the angle aid. Do not use the angle aid to administer an actual injection.

Finally, always be sure to keep track of the injection date and site.

Well, now you know how to give a dose of DUPIXENT. If you follow these steps, you’ll be a pro in no time.

Feel free to rewatch this video as many times as you’d like. And again, reach out to your healthcare provider or call the DUPIXENT MyWay hotline if you have any questions.

Well, that wasn’t so bad, was it?

SON: What?

Injection Instructions

Administering DUPIXENT may seem intimidating, but following the instructions below will help reinforce the steps your healthcare
provider showed you and your teen. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider.

  1. Remove

    Remove the DUPIXENT Syringe from the carton by holding the middle of the Syringe Body.

    • Do not pull off the Needle Cap until you are ready to inject.
    • Do not use the DUPIXENT Syringe if it has been dropped on a hard surface or damaged.
  2. Prepare

    Ensure you have the following:

    * Items not included in the carton

  3. Check

    When you receive your DUPIXENT Syringes, always check to see that:

    • You have the correct medicine and dose.
    • The expiration date on the Single-Dose Pre-filled Syringe has not passed.
      • Do not use the DUPIXENT Syringe if the expiration date has passed.
  4. Inspect
    • Look at the medicine through the Viewing Window on the DUPIXENT Syringe: Check to see if the liquid is clear and colorless to pale yellow.
    • Note: You may see an air bubble, this is normal.
      • Do not use the DUPIXENT Syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles.
  5. Wait 45 minutes

    Lay the DUPIXENT Syringe on a flat surface and let it naturally warm to room temperature for at least 45 minutes.

    • Do not heat the DUPIXENT Syringe.
    • Do not put the DUPIXENT Syringe into direct sunlight.
    • Do not keep DUPIXENT Syringes at room temperature for more than 14 days. Throw away (dispose of) any DUPIXENT Syringes that have been left at room temperature for longer than 14 days.
  6. Choose your injection site
    • You can inject into your thigh or stomach, except for the 2 inches (5 cm) around your belly button (navel).
    • If a caregiver injects your dose, they can also use the outer area of the upper arm.
    • Choose a different site each time you inject DUPIXENT.
    • Do not inject into skin that is tender, damaged, bruised or scarred.
  7. Clean
    • Wash your hands.
    • Clean the injection site with an alcohol wipe.
    • Let your skin dry before injecting.
    • Do not touch the injection site again or blow on it before the injection.
  8. Remove Needle Cap
    • Hold the DUPIXENT Syringe in the middle of the Syringe Body with the Needle pointing away from you and pull off the Needle Cap.
    • Do not put the Needle Cap back on.
    • Do not touch the Needle.
      Inject your medicine right away after removing the Needle Cap.
  9. Pinch

    Pinch a fold of skin at the injection site (thigh or stomach, except 2 inches around your belly button, or outer area of the upper arm if injected by your caregiver). The figure on the right shows an example of pinching a fold of skin on your stomach.

    Pinch

  10. Insert
    • Insert the Needle completely into the fold of the skin at about a 45-degree angle.
  11. Push
    • Relax the pinch.
    • Push the Plunger Rod down slowly and steadily as far as it will go, until the DUPIXENT Syringe is empty.
    • Note: You will feel some resistance. This is normal.
  12. Release and Remove
    • Lift your thumb to release the Plunger Rod until the Needle is covered by the Needle Shield and then remove the Syringe from the injection site.
    • Lightly press a cotton ball or gauze on the injection site if you see any blood.
    • Do not put the Needle Cap back on.
    • Do not rub your skin after the injection.
  13. Dispose
    • Put your used Needles, DUPIXENT Syringes, and Needle Caps in an FDA-cleared sharps disposal container right away after use.
    • Do not dispose of (throw away) Needles, DUPIXENT Syringes, and Needle Caps in your household trash.
    • If you do not have a FDA-cleared sharps disposal container, you may use a household container that is:
      • Made of a heavy-duty plastic,
      • Can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
      • Upright and stable during use,
      • Leak-resistant, and
      • Properly labeled to warn of hazardous waste inside the container
    • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used Needles and Syringes.
    • For more information about safe sharps disposal and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal.
    • Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container.
    • Do not put the Needle Cap back on.
Show all 13 Steps
  1. Remove

    Remove the DUPIXENT Syringe from the carton by holding the middle of the Syringe Body.

    • Do not pull off the Needle Cap until you are ready to inject.
    • Do not use the DUPIXENT Syringe if it has been dropped on a hard surface or damaged.
  2. Prepare

    Ensure you have the following:

    * Items not included in the carton

  3. Check

    When you receive your DUPIXENT Syringes, always check to see that:

    • You have the correct medicine and dose.
    • The expiration date on the Single-Dose Pre-filled Syringe has not passed.
      • Do not use the DUPIXENT Syringe if the expiration date has passed.
  4. Inspect
    • Look at the medicine through the Viewing Window on the DUPIXENT Syringe: Check to see if the liquid is clear and colorless to pale yellow.
    • Note: You may see an air bubble, this is normal.
      • Do not use the DUPIXENT Syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles.
  5. Wait 30 minutes

    Lay the DUPIXENT Syringe on a flat surface and let it naturally warm to room temperature for at least 30 minutes.

    • Do not heat the DUPIXENT Syringe.
    • Do not put the DUPIXENT Syringe into direct sunlight.
    • Do not keep DUPIXENT Syringes at room temperature for more than 14 days. Throw away (dispose of) any DUPIXENT Syringes that have been left at room temperature for longer than 14 days.
  6. Choose your injection site
    • You can inject into your thigh or stomach, except for the 2 inches (5 cm) around your belly button (navel).
    • If a caregiver injects your dose, they can also use the outer area of the upper arm.
    • Choose a different site each time you inject DUPIXENT.
    • Do not inject into skin that is tender, damaged, bruised or scarred.
  7. Clean
    • Wash your hands.
    • Clean the injection site with an alcohol wipe.
    • Let your skin dry before injecting.
    • Do not touch the injection site again or blow on it before the injection.
  8. Remove Needle Cap
    • Hold the DUPIXENT Syringe in the middle of the Syringe Body with the Needle pointing away from you and pull off the Needle Cap.
    • Do not put the Needle Cap back on.
    • Do not touch the Needle.
      Inject your medicine right away after removing the Needle Cap.
  9. Pinch

    Pinch a fold of skin at the injection site (thigh or stomach, except 2 inches around your belly button, or outer area of the upper arm if injected by your caregiver). The figure on the right shows an example of pinching a fold of skin on your stomach.

    Pinch

  10. Insert
    • Insert the Needle completely into the fold of the skin at about a 45-degree angle.
  11. Push
    • Relax the pinch.
    • Push the Plunger Rod down slowly and steadily as far as it will go, until the DUPIXENT Syringe is empty.
    • Note: You will feel some resistance. This is normal.
  12. Release and Remove
    • Lift your thumb to release the Plunger Rod until the Needle is covered by the Needle Shield and then remove the Syringe from the injection site.
    • Lightly press a cotton ball or gauze on the injection site if you see any blood.
    • Do not put the Needle Cap back on.
    • Do not rub your skin after the injection.
  13. Dispose
    • Put your used Needles, DUPIXENT Syringes, and Needle Caps in an FDA-cleared sharps disposal container right away after use.
    • Do not dispose of (throw away) Needles, DUPIXENT Syringes, and Needle Caps in your household trash.
    • If you do not have a FDA-cleared sharps disposal container, you may use a household container that is:
      • Made of a heavy-duty plastic,
      • Can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
      • Upright and stable during use,
      • Leak-resistant, and
      • Properly labeled to warn of hazardous waste inside the container
    • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used Needles and Syringes.
    • For more information about safe sharps disposal and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal.
    • Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container.
    • Do not put the Needle Cap back on.
Show all 13 Steps
Find a Specialist Who
Treats Eczema

Use this Healthgrades™ tool to easily find nearby specialists with experience in treating teens and adults with uncontrolled moderate-to-severe eczema (atopic dermatitis).

Share Your Story

Your experience with DUPIXENT is unique and yours to tell, and we want to know your story. It can inspire and empower people going through similar experiences. If selected, you may be featured in print materials, on social media, or in videos.

Interested in hearing more or sharing your story?
Call 1‑844‑DUPIXENT, option 5
(1‑844‑387‑4936)