Frequently Asked Questions


DUPIXENT is a prescription treatment used with other medicines to treat chronic rhinosinusitis with nasal polyposis (CRSwNP) in adults whose disease is not controlled. It is not known if DUPIXENT is safe or effective in children with CRSwNP under 18 years of age.


Do not use DUPIXENT if you are allergic to dupilumab or to any of the ingredients in DUPIXENT.

Before using DUPIXENT, tell your doctor about all your medical conditions, including if you:

  • have eye problems.
  • have a parasitic (helminth) infection.
  • are scheduled to receive any vaccinations. You should not receive a "live vaccine" if you are treated with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • Pregnancy Registry. There is a pregnancy registry for women who take DUPIXENT during pregnancy. The purpose of this registry is to collect information about your health and your baby’s health. You can talk to your healthcare provider or contact 1-877-311-8972 or go to to enroll in this registry or get more information.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines; have asthma and use an asthma medicine; and have CRSwNP, and also have asthma. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine to come back.

The effectiveness and safety of DUPIXENT has been studied in 2 clinical trials with 724 adults with uncontrolled chronic rhinosinusitis with nasal polyposis (CRSwNP).

  • In both studies, DUPIXENT was proven to help patients breathe better by relieving nasal congestion and reducing the size of nasal polyps compared to placebo group.

Patients enrolled in these studies included subjects with CRSwNP despite prior sino-nasal surgery or treatment with, or who were ineligible to receive or were intolerant to, systemic corticosteroids in the past 2 years. Patients with chronic rhinosinusitis without nasal polyposis were not included in these trials.


DUPIXENT can cause serious side effects, including:

  • Allergic reactions (hypersensitivity), including a severe reaction known as anaphylaxis. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following symptoms:
    • breathing problems
    • fever
    • general ill feeling
    • swollen lymph nodes
    • swelling of the face, mouth, and tongue
    • hives
    • itching
    • fainting, dizziness, feeling lightheaded (low blood pressure)
    • joint pain
    • skin rash
  • Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision.
  • Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have:
    • rash
    • shortness of breath
    • persistent fever
    • chest pain
    • a feeling of pins and needles or numbness of your arms or legs

Some of the most common side effects in patients with chronic rhinosinusitis with nasal polyposis include:

  • injection site reactions
  • eye and eyelid inflammation, including redness, swelling, and itching
  • high count of a certain white blood cell (eosinophilia)
  • trouble sleeping (insomnia)
  • toothache
  • gastritis
  • joint pain (arthralgia)

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.


DUPIXENT is given as an injection under the skin (subcutaneous injection) at different injection sites. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider. Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it.

  • The recommended dose of DUPIXENT for adult patients is 300 mg given every other week.
  • Talk to your healthcare provider and see the detailed instructions for use that comes with DUPIXENT for information on how to prepare and inject DUPIXENT and how to properly store and throw away (dispose of) used DUPIXENT Pre-filled Syringes or DUPIXENT Pre-filled Pens prior to taking the drug.

Watch this video to learn how to administer DUPIXENT.

DUPIXENT can be injected into the thigh, stomach (except for the 2 inches around the belly button), or outer area of the upper arm (if caregiver injects). A different site should be chosen each time DUPIXENT is injected.

  • Follow your healthcare provider's instructions and read the Instructions for Use for full details on preparation, administration, and disposal of your injection.


For more information about DUPIXENT support and services, you can enroll in DUPIXENT MyWay®, a program that can provide:

  • Tips and tools to help your experience on DUPIXENT.
  • Nurse educators offering supplemental injection training. Your doctor will show you the proper procedure first and decide whether you can self-inject.
  • Financial support for eligible commercially insured patients.
  • Assistance with insurance questions.
  • Assistance locating a pharmacy that can dispense your DUPIXENT prescription.

Sign up or call a support coordinator at 1-844-DUPIXENT (1-844-387-4936) to learn more.


Certain retail pharmacies or specialty pharmacies can fill your prescription. These pharmacies can:

  • Coordinate directly with your doctor.
  • Manage the handling and service requirements of specialty drugs.
  • Ship your medication directly to your home in a special cooler to help make sure the correct temperature is maintained through the process.
  • Stay in contact with you and your doctor throughout the treatment.


Notify your pharmacy. In fact, when you take medications that require refills regularly over time, it's always good to periodically check that your pharmacy has your most up-to-date insurance information on file. This can help you avoid potential delays in getting your prescription.

If you have additional questions, contact 1-844-DUPIXENT (1-844-387-4936) to enroll in DUPIXENT MyWay® and speak to a Nurse Educator.

With the DUPIXENT MyWay Copay Card, eligible patients may pay as little as $0 for every fill of DUPIXENT if they meet the following requirements*:

  • Have commercial insurance
  • Have a DUPIXENT prescription for an FDA-approved condition
  • Are a resident of the 50 United States, the District of Columbia, or Puerto Rico

*THIS IS NOT INSURANCE. Not valid for prescriptions paid, in whole or in part, by Medicaid, Medicare, VA, DoD, TRICARE, or other federal or state programs including any state pharmaceutical assistance programs. This program is not valid where prohibited by law, taxed or restricted. DUPIXENT MyWay® reserves the right to rescind, revoke, terminate, or amend this offer, eligibility, and terms of use at any time without notice. Additional terms and conditions apply.


Through the Patient Assistance Program, eligible patients who are uninsured or whose insurance does not cover DUPIXENT could receive DUPIXENT free of charge.

Those who may qualify must be at least 18 years of age or older, a resident of the 50 United States, the District of Columbia, or Puerto Rico, and demonstrate a financial need with a total annual adjusted gross income of $100,000 or less.

The DUPIXENT MyWay team will research each patient’s situation and determine eligibility. For more information, call 1-844-DUPIXENT (1-844-387-4936), option 1.