How to Take DUPIXENT

DUPIXENT IS TAKEN BY INJECTION

DUPIXENT is a form of medicine called a biologic and taken by injection under the skin (subcutaneous injection).

ONE DOSE. TWICE A MONTH.

Use DUPIXENT exactly as prescribed by your doctor. Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it. The recommended dose for uncontrolled chronic rhinosinusitis with nasal polyposis (CRSwNP) is 300 mg every 2 weeks. DUPIXENT is given as an injection under the skin (subcutaneous injection) into different injection sites.

Talk to your healthcare provider, and download the detailed Instructions for Use for information on how to prepare and inject DUPIXENT and how to properly store and dispose of used DUPIXENT Pre-filled Syringes and DUPIXENT Pre-filled Pens. Do not try and inject DUPIXENT until you have been shown the right way by your healthcare provider.

How to administer dupixent

DUPIXENT can be taken by a pre-filled syringe or pre-filled pen. To see the video and written instructions that match how you take DUPIXENT, select the correct option below.

Take your treatment with confidence. Watch the video for a supplemental demonstration on how to use and dispose of DUPIXENT.

300 mg Pre-filled Syringe
Details

DUPIXENT is available as a single-dose pre-filled syringe with needle shield. DUPIXENT is given as an injection under the skin
(subcutaneous injection) into different injection sites.

PRE-FILLED SYRINGE Self-Injection

Transcript

Hi there. I'm Laura.

Today I'm going to show you how to properly self-inject a dose of DUPIXENT (dupilumab).

You've already learned how to self-inject with your healthcare provider.

I'm here to guide your first at-home experience.

When I first started self-injections, I found syringes really intimidating. I've gotten better at the process since then, so I want to share those steps with you today.

I'll show you: what supplies to gather, how to prep the injection area, and how to inject the dose and discard your used syringe.

If you haven't yet read the instructions for use located in your treatment packaging, pause the video and take a look.

I found it helpful to understand the plunger, syringe body, and needle cap before handling the syringe itself.

Contact your healthcare provider or the DUPIXENT MyWay Hotline with any questions.

It's time for me to take my DUPIXENT injection. Feel free to watch me and follow along as I self-inject.

Narration

Take your medication out of the refrigerator. Never freeze your syringe.

Remove the syringe by holding the middle of the syringe body.

Do not use the syringe if it has been dropped on a hard surface or is damaged.

Do not pull off the needle cap or touch the plunger rod until you are ready to inject.

Do not pull back on the plunger rod at any time.

Keep DUPIXENT syringes and all medicines out of the reach of children.

If you have an unused syringe, return it to the refrigerator in the original carton to protect it from light.

Your DUPIXENT pre-filled syringe may appear different than what I am using in this video, based on the prescribed dose. If you have questions about the dosage prescribed to you, please contact your healthcare provider.

Check the label to make sure the medication inside is correct and the expiration date has not passed. If it isn't right, contact your pharmacy.

You may see an air bubble, this is normal. Do not try to get rid of any air bubbles.

The liquid inside should be clear, and colorless to pale yellow.

Do not use the syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles. Throw away, dispose of, the used DUPIXENT single- dose pre-filled syringe right away after use.

If you have any questions about whether the syringe is okay to use, please call the DUPIXENT MyWay Hotline or your healthcare provider.

Lay the syringe on a flat surface and let it naturally warm to room temperature.

The recommended warming time for the 200 mg syringe is 30 minutes, and for the 300 mg syringe, it's 45 minutes.

Do not heat the syringe.

Do not put the syringe into direct sunlight.

Do not keep DUPIXENT at room temperature for more than 14 days. Throw away, dispose of, any syringe that has been left at room temperature for longer than 14 days.

Do not shake the syringe.

While you wait, gather the additional materials necessary to self-inject.

You need one cotton ball or gauze, one alcohol wipe, and a puncture resistant Sharps Disposal Container.

If you don't have a Sharps Disposal Container, call a DUPIXENT MyWay representative to request a complimentary Sharps Disposal Container.

Now, take your supplies to an area where you can sit comfortably.

When you are ready to get started, wash your hands thoroughly.

Choose your injection site. Both the stomach and thigh are acceptable, except for the two inches around your belly button.

If a caregiver gives you the injection, the outer area of the upper arm is also an option. The person giving the injection should follow the same preparation procedure.

Be sure to choose a different site each time you inject DUPIXENT.

Do not inject through clothes.

Do not inject into skin that is tender, damaged or is bruised or scarred.

Clean your skin with the alcohol wipe.

Do not touch the injection site again or blow on it before the injection. Let your skin dry before injection.

Hold the DUPIXENT syringe in the middle of the Syringe Body with the Needle pointing away from you and carefully remove the cap from the syringe.

Do not use if the needle cap is missing or not securely attached.

Do not put the needle cap back on.

Do not touch the needle. Inject the medicine right away after removing the Needle cap.

Pinch a fold of skin at the injection site. Pinching your skin helps the medicine go into a fatty layer, just below the skin, and not into the muscle.

Take a deep breath.

Continue to pinch, as you insert the needle completely at about a 45° angle.

Relax your pinch.

Push the plunger down slowly and steadily as far as it will go, until the syringe is empty.

You will feel some resistance. This is normal.

Lift your thumb to release the Plunger Rod until the Needle is covered by the Needle Shield and then remove the Syringe from the injection site.

Lightly press a cotton ball or gauze on the injection site if you see any blood. Do not put the needle cap back on.

Do not rub your skin after the injection.

You can also cover the site with a bandage.

Put your used Needles, DUPIXENT Syringes, and Needle Caps in a FDA-cleared Sharps Disposal Container right away after use.

Do not dispose of needles, DUPIXENT Syringes, and Needle Caps in your household trash.

Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once it is full.

Do not recycle your used Sharps Disposal Container.

Do not reuse the syringe.

If you would like to practice before doing the actual injection and you have received the DUPIXENT training kit from your doctor's office, you can practice the 45° injection angle with your training syringe and the angle aid, and you could always watch the video again.

Remember, do not use the angle-aid to administer an actual injection.

Narration - On Camera Ending

Be sure to keep track of your injection date and site.

Thank you for joining me today. Remember, you can re-watch this video as often as you like to refresh your memory.

Contact your healthcare provider or the DUPIXENT MyWay Hotline with any questions or concerns.

Narration - ISI Indication

300 mg pre-filled syringe INSTRUCTIONS FOR USE

Administering DUPIXENT may seem intimidating, but following the pre-filled syringe Instructions for Use download will help reinforce the steps your healthcare provider showed you. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider. Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it.

get the 300 mg
pre-filled
syringe
instructions for use

Take your treatment with confidence. Watch the video for a supplemental demonstration on how to self-inject and dispose of DUPIXENT.

The DUPIXENT 300 mg Pre-Filled Pen
is now available!

Another approach to 300 mg dosing.

Your treatment is delivered without seeing the needle. Talk to your doctor to see if it's right for you.

PRE-FILLED PEN Self-Injection

Transcript

Tom:

Hey, I’m Tom. Thanks for watching. Today I’m going to show you how to properly self-inject a dose of DUPIXENT (dupilumab), using the single-dose pre-filled pen.

Since you’ve already learned how to self-inject with your healthcare provider, I’ll be here to guide your through your first at-home experience.

To some, self-injections can be intimidating. I was nervous when I first started, but with some practice and help from my healthcare provider, I’ve gotten much better at the process, and I want to share those steps with you, today.

First thing we’ll go over is: What supplies to gather, How to prep the injection area, and How to inject the dose and discard your single-use, pre-filled pen.

If you haven’t yet read the instructions for use located in your DUPIXENT treatment packaging, pause the video and take a look. Please read all the instructions carefully, before using the pre-filled pen.

VO:

Let’s take a closer look at the pre-filled pen. I found it helpful to review the different parts of the pre-filled pen, like the cap, the window and the needle cover, before handling the pre-filled pen itself.

Contact your healthcare provider or the DUPIXENT MyWay Hotline with questions. They’re always there to help.

Tom:

Ok, it’s time for me to take my DUPIXENT Injection. Feel free to watch me as I self-inject.

VO:

To begin, take your medication out of the refrigerator.

  • Keep the pre-filled pen and all medicines out of the reach of children
  • Keep unused pre-filled pens in the original carton and store in the refrigerator between or 35° - 46° F [2°-8°C]

Take one pen out of the packaging by holding the middle of the pen body.

Now, let’s check the label on the pen to ensure that the medication and dosage strength are correct and the expiration date has not passed.

Do not use the pen if the expiration date has passed. If the dosage strength or expiration date isn’t right, contact your pharmacy.

Next, take a look at the medicine through the viewing window. The liquid inside should be clear and colorless, to pale yellow. You may see an air bubble. This is totally normal.

  • Do not inject DUPIXENT if the liquid inside is discolored or cloudy, or contains visible flakes or particles .
  • Do not use the pre-filled pen if the window is solid yellow.
  • Do not use the pre-filled pen if it has been damaged.
  • Do not use the pre-filled pen if the cap is missing or not securely attached .

If you have any questions about whether the pen is okay to use, please call the DUPIXENT MyWay Hotline or your healthcare provider.

If you have an unused pre-filled pen, return it to the refrigerator in the original carton to protect it from light.

Lay the pre-filled pen on a flat surface and let it naturally warm to room temperature.

  • Do not store DUPIXENT pre-filled pens at room temperatures more than 77°F (25°C)

The recommended warming time for the 300mg pen is 45 minutes.

  • Do not freeze or heat the pre-filled pen
  • Do not put the pre-filled pen into direct sunlight
  • Do not keep DUPIXENT at room temperature, 77°F (25°C), for more than 14 days
  • Throw away any used pre-filled pen that has been left at room temperature for more than 14 days
  • Do not shake the pre-filled pen at any time

As the pen warms up, let’s gather some additional materials you’ll need to self-inject. You’ll need a cotton ball or gauze, an alcohol wipe, and a puncture resistant Sharps Disposal Container.

If you don’t have a Sharps disposal container, call a DUPIXENT MyWay representative to request a complimentary Sharps disposal Container.

If you don’t have a puncture resistant disposal container, call your pharmacy, healthcare provider, or DUPIXENT patient support to request a puncture resistant disposal container.

We’re almost ready to inject DUPIXENT.

First, let’s wash our hands thoroughly with soap and water.

Now, take your supplies to an area where you can sit comfortably. I prefer the comfort of my living room couch, you might prefer the bathroom, or your bedroom for privacy.

Next, let’s choose an injection site. Both the stomach and thigh are acceptable, except for the 5 cm [OR 2 in] around your belly button.

If a caregiver gives you the injection, the outer area of the upper arm is also an option. The person giving the injection should follow the same preparation procedure.

Be sure to choose a different site each time you inject DUPIXENT.

  • Do not inject through clothes
  • Do not inject into skin that is tender, damaged, bruised or scarred, or into areas with visible veins.

Now, clean your skin with the alcohol wipe.

Do not touch the injection site again or blow on it before the injection.

Let your skin dry before injection.

Pick up the pen by holding the middle of the pen body with the needle pointing away from you. With your other hand, pull the cap straight off. Once you have removed the cap, do not put it back on.

  • Do not twist the cap off
  • Do not remove the cap until you are ready to inject
  • Do not press or touch the needle cover with your fingers
  • Do not try to put the cap back on once you’ve removed it

Place the needle cover on your skin at approximately a 90-degree angle. Make sure you can see the injector window.

Press down and hold the pen firmly against your skin until you can no longer see the needle cover. There will be a “click” when the injection starts.

As you hold the pen firmly against your skin, the injector window will start to turn yellow. The injection can take up to 20 seconds.

  • Be sure to watch the window turn fully yellow.

You may hear a second “click”. Check to see if the entire window has turned yellow before removing the pen. Slowly count to 5 and then lift the pen straight up off the skin.

  • Keep the pen pressed against. Your skin as you count to 5 to ensure you are getting a full dose of DUPIXENT.

That’s it!

If the window does not turn fully yellow, remove the pen and call your healthcare provider. Do not give yourself a second dose without speaking to your healthcare provider.

Lightly press a cotton ball or gauze on the injection site if you see any blood. You can also cover the site with a bandage. If the bleeding doesn’t stop, contact your healthcare provider.

  • Do not rub your skin after the injection.

Be sure to put the used pen and its cap into a puncture-resistant Sharps Disposal Container right away after use.

  • Your puncture resistant disposal container may look different than the one shown here.
  • Do not re-use the pre-filled pen
  • Do not throw away the used pen in your household waste
  • Do not recycle your used puncture-resistant container
  • Keep your Sharps disposal container out of the reach of children

Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once it is full.

Be sure to keep track of your injection date and site.

Tom:

Thank you for joining me today. Remember, you can re-watch this video as often as you like to refresh your memory.

Contact your healthcare provider or the DUPIXENT MyWay Hotline with any questions or concerns.

300 mg pre-filled pen INSTRUCTIONS FOR USE

Administering DUPIXENT may seem intimidating, but following the pre-filled pen Instructions for Use download will help reinforce the steps your healthcare provider showed you. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider. Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it.