How to Take DUPIXENT


DUPIXENT is a form of medicine called a biologic and taken by injection under the skin (subcutaneous injection).


Use DUPIXENT exactly as prescribed by your healthcare provider. Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it. The recommended dose for uncontrolled chronic rhinosinusitis with nasal polyposis (CRSwNP) is 300 mg every 2 weeks. DUPIXENT comes as a single-dose pre-filled syringe with needle shield. DUPIXENT is given as an injection under the skin (subcutaneous injection) into different injection sites.

Watch the video for supplemental information on how to use and dispose of DUPIXENT.

Talk to your healthcare provider, and download the detailed Instructions for Use for information on how to prepare and inject DUPIXENT and how to properly store and dispose of used DUPIXENT Pre-filled Syringes. Do not try and inject DUPIXENT until you have been shown the right way by your healthcare provider.



Hi there. I'm Laura.

Today I'm going to show you how to properly self-inject a dose of DUPIXENT (dupilumab).

You've already learned how to self-inject with your healthcare provider.

I'm here to guide your first at-home experience.

When I first started self-injections, I found syringes really intimidating. I've gotten better at the process since then, so I want to share those steps with you today.

I'll show you: what supplies to gather, how to prep the injection area, and how to inject the dose and discard your used syringe.

If you haven't yet read the instructions for use located in your treatment packaging, pause the video and take a look.

I found it helpful to understand the plunger, syringe body, and needle cap before handling the syringe itself.

Contact your healthcare provider or the DUPIXENT MyWay Hotline with any questions.

It's time for me to take my DUPIXENT injection. Feel free to watch me and follow along as I self-inject.


Take your medication out of the refrigerator. Never freeze your syringe.

Remove the syringe by holding the middle of the syringe body.

Do not use the syringe if it has been dropped on a hard surface or is damaged.

Do not pull off the needle cap or touch the plunger rod until you are ready to inject.

Do not pull back on the plunger rod at any time.

Keep DUPIXENT syringes and all medicines out of the reach of children.

If you have an unused syringe, return it to the refrigerator in the original carton to protect it from light.

Your DUPIXENT pre-filled syringe may appear different than what I am using in this video, based on the prescribed dose. If you have questions about the dosage prescribed to you, please contact your healthcare provider.

Check the label to make sure the medication inside is correct and the expiration date has not passed. If it isn't right, contact your pharmacy.

You may see an air bubble, this is normal. Do not try to get rid of any air bubbles.

The liquid inside should be clear, and colorless to pale yellow.

Do not use the syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles. Throw away, dispose of, the used DUPIXENT single- dose pre-filled syringe right away after use.

If you have any questions about whether the syringe is okay to use, please call the DUPIXENT MyWay Hotline or your healthcare provider.

Lay the syringe on a flat surface and let it naturally warm to room temperature.

The recommended warming time for the 200 mg syringe is 30 minutes, and for the 300 mg syringe, it's 45 minutes.

Do not heat the syringe.

Do not put the syringe into direct sunlight.

Do not keep DUPIXENT at room temperature for more than 14 days. Throw away, dispose of, any syringe that has been left at room temperature for longer than 14 days.

Do not shake the syringe.

While you wait, gather the additional materials necessary to self-inject.

You need one cotton ball or gauze, one alcohol wipe, and a puncture resistant Sharps Disposal Container.

If you don't have a Sharps Disposal Container, call a DUPIXENT MyWay representative to request a complimentary Sharps Disposal Container.

Now, take your supplies to an area where you can sit comfortably.

When you are ready to get started, wash your hands thoroughly.

Choose your injection site. Both the stomach and thigh are acceptable, except for the two inches around your belly button.

If a caregiver gives you the injection, the outer area of the upper arm is also an option. The person giving the injection should follow the same preparation procedure.

Be sure to choose a different site each time you inject DUPIXENT.

Do not inject through clothes.

Do not inject into skin that is tender, damaged or is bruised or scarred.

Clean your skin with the alcohol wipe.

Do not touch the injection site again or blow on it before the injection. Let your skin dry before injection.

Hold the DUPIXENT syringe in the middle of the Syringe Body with the Needle pointing away from you and carefully remove the cap from the syringe.

Do not use if the needle cap is missing or not securely attached.

Do not put the needle cap back on.

Do not touch the needle. Inject the medicine right away after removing the Needle cap.

Pinch a fold of skin at the injection site. Pinching your skin helps the medicine go into a fatty layer, just below the skin, and not into the muscle.

Take a deep breath.

Continue to pinch, as you insert the needle completely at about a 45° angle.

Relax your pinch.

Push the plunger down slowly and steadily as far as it will go, until the syringe is empty.

You will feel some resistance. This is normal.

Lift your thumb to release the Plunger Rod until the Needle is covered by the Needle Shield and then remove the Syringe from the injection site.

Lightly press a cotton ball or gauze on the injection site if you see any blood. Do not put the needle cap back on.

Do not rub your skin after the injection.

You can also cover the site with a bandage.

Put your used Needles, DUPIXENT Syringes, and Needle Caps in a FDA-cleared Sharps Disposal Container right away after use.

Do not dispose of needles, DUPIXENT Syringes, and Needle Caps in your household trash.

Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once it is full.

Do not recycle your used Sharps Disposal Container.

Do not reuse the syringe.

If you would like to practice before doing the actual injection and you have received the DUPIXENT training kit from your doctor's office, you can practice the 45° injection angle with your training syringe and the angle aid, and you could always watch the video again.

Remember, do not use the angle-aid to administer an actual injection.

Narration - On Camera Ending

Be sure to keep track of your injection date and site.

Thank you for joining me today. Remember, you can re-watch this video as often as you like to refresh your memory.

Contact your healthcare provider or the DUPIXENT MyWay Hotline with any questions or concerns.

Narration - ISI Indication


Administering DUPIXENT may seem intimidating, but following the instructions below will help reinforce the steps your healthcare provider showed you. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider. Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it.