AN FDA-APPROVED WAY TO TREAT PN–THAT’S A WIN FOR SKIN

A proactive treatment

DUPIXENT doesn’t just treat your symptoms. It works under the skin, and may help bring balance between your skin, nervous system, and immune system by controlling a source of unwanted inflammation under the surface of the skin to help keep you one step ahead of your PN symptoms.

dupixent:

  • Is a biologic that proactively treats your PN
  • Can help break the intense cycle of itching
  • Helps heal your skin from within
  • Is not a steroid
  • Is not an immunosuppressant
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with dupixent

How Does DUPIXENT Work to Treat PN?

Learn more about PN, and how
DUPIXENT works inside
the body to
help control PN symptoms.

Learn About a Treatment for Adults With Prurigo Nodularis (PN)

Hi, everyone. My name is Sydney.

I’ve been diagnosed with prurigo nodularis, also known as Picker’s Nodules, Nodularis Prurigo, and Eczema Prurigo. My healthcare team and I call it PN.

I'm on my way to an appointment with my skin specialist right now to speak about DUPIXENT® (dupilumab), the first FDA-approved treatment for PN in adults.

It’s a biologic that may help you stay one step ahead of PN symptoms.

And here’s some IMPORTANT SAFETY INFORMATION. Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT.

Stay tuned until the end of my story, where you’ll see additional Important Safety Information.

Because PN is uncommon, it made it difficult to diagnose—and hard for me to discuss my symptoms and how they affect me.

In fact, at one point I was even told it might all be in my head!

Say what you will about unicorns, but PN is one hundred percent real.

My PN symptoms—the intense itch and painful nodules—are persistent and can’t be ignored.

My skin specialist explained that PN is a chronic disease that begins inside the body. Research suggests that an abnormal relationship between the skin, nervous system, and immune system can lead to inflammation.

On the surface of the skin, I feel an intense itch and see the development of bumpy lesions, or nodules, over time.

Mine are typically brown, but they can also be pink, red, or a range of other colors based on your skin tone.

Beneath your skin, there are immune cells and nerve cells, both of which affect the health of your skin.

In fact, they all have an impact on each other.

Immune cells send out inflammatory, or “warning,” signals to help protect the skin.

Nerve cells, which are located in the skin, signal sensations, like itchiness, to the brain.

But when you have PN, your nerves may send too many itch signals to the brain. This can lead to intense itching.

Because of the constant itching and scratching, the immune cells in your body send out too many inflammatory signals. This results in chronic inflammation and more itching.

And continued scratching can result in painful nodules that can cause burning and stinging sensations, bleeding, or scarring on your skin. It’s a vicious cycle!

While I have tried other options, they aren’t always enough to help with the intense itching and appearance of nodules.

My skin specialist and I agree that DUPIXENT may be the right treatment approach for me to try now because DUPIXENT may help bring balance by controlling a source of chronic inflammation under the surface of the skin, to help me stay one step ahead of PN symptoms.

In two clinical studies with 311 adults with PN, almost 3 times as many adults had less itch at 24 weeks, and in one study, some adults had less itch in as little as 12 weeks.

Also, almost 3 times as many adults had skin clear or almost clear of PN bumps at 24 weeks.

The most common side effects in patients with prurigo nodularis include eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, herpes virus infections, common cold symptoms (nasopharyngitis), dizziness, muscle pain, and diarrhea.

If what I’ve shared about PN sounds familiar to you, it may be time to ask about DUPIXENT!

Check out the DUPIXENT.com symptom tracking tool and doctor discussion guide to help you have a more productive conversation with your skin specialist.

Thanks for letting me share what I’ve learned with you today!

Stay tuned to hear important safety information about DUPIXENT.
 

Important Safety Information
and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have eye problems.
  • have a parasitic (helminth) infection.
  • are scheduled to receive any vaccinations. You should not receive a “live vaccine” right before and during treatment with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical or inhaled corticosteroid medicines or if you have prurigo nodularis and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
  • Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an eye exam if needed.
  • Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects in patients with prurigo nodularis include eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, herpes virus infections, common cold symptoms (nasopharyngitis), dizziness, muscle pain, and diarrhea.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used to treat adults with prurigo nodularis (PN). It is not known if DUPIXENT is safe and effective in children with prurigo nodularis under 18 years of age.

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FIND A NEARBY SPECIALIST WHO TREATS PN

Use this Healthgrades™ tool to easily find nearby specialists with
experience in treating adults suffering from prurigo nodularis.

Sanofi US and Regeneron do not endorse or recommend any
particular physician, and search results do not include a
comprehensive list of doctors in your area.