FREQUENTLY ASKED QUESTIONS

Before using DUPIXENT, tell your doctor about all your medical conditions, including if you:

• have eye problems.
• have a parasitic (helminth) infection.
• are scheduled to receive any vaccinations. You should not receive a "live vaccine" right before and during treatment with DUPIXENT.
• are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • A pregnancy registry for women who take DUPIXENT during pregnancy collects information about the health of you and your baby. To enroll or get more information call 1-877-311-8972 or go to https://mothertobaby.org/ongoing-study/dupixent/.
• are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines; have asthma and use an asthma medicine; and have CRSwNP, and also have asthma. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine to come back.

The effectiveness and safety of DUPIXENT has been studied in the largest clinical trials to date for CRSwNP with 724 adults with uncontrolled chronic rhinosinusitis with nasal polyposis (CRSwNP).

• In both studies, DUPIXENT was proven to help patients breathe better by relieving nasal congestion and reducing the size of nasal polyps compared to placebo group.

Patients enrolled in these studies included subjects with CRSwNP regardless of whether they had prior sino-nasal surgery or treatment with, or who were ineligible to receive or were intolerant to, systemic corticosteroids in the past 2 years. Patients with chronic rhinosinusitis without nasal polyposis were not included in these trials.

DUPIXENT can cause serious side effects, including:

• Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following symptoms:

  • breathing problems or wheezing
  • fast pulse
  • fever
  • general ill feeling
  • swollen lymph nodes

  • swelling of the face, lips, mouth, tongue, or throat
  • hives
  • itching
  • nausea or vomiting

  • fainting, dizziness, feeling lightheaded
  • joint pain
  • skin rash
  • cramps in your stomach-area
• Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an eye exam if needed.

• Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have:

  • rash
  • worsening shortness of breath
  • persistent fever

  • chest pain
  • a feeling of pins and needles or numbness of your arms or legs
• Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects in patients with chronic rhinosinusitis with nasal polyposis include:

• injection site reactions
• eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision
• high count of a certain white blood cell (eosinophilia)
• trouble sleeping (insomnia)
• toothache
• gastritis
• joint pain (arthralgia)

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

DUPIXENT should be refrigerated at 36°F to 46°F in the original carton to protect from light. If necessary, DUPIXENT may be kept at room temperature up to 77°F (25°C) for a maximum of 14 days. Do not store above 77°F (25°C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded.

Do not expose DUPIXENT to heat or direct sunlight.

Do not freeze. Do not shake.

Please refer to the DUPIXENT Instructions for Use for complete storage instructions.

Whether you are traveling or not, it’s important to store DUPIXENT in the original carton to protect it from light.

Store refrigerated at 36 °F to 46 °F (2 °C to 8 °C) in the original carton to protect from light. If necessary, DUPIXENT may be kept at room temperature up to 77 °F (25 °C) for a maximum of 14 days. Do not store above 77 °F (25 °C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded.

Notify your pharmacy. In fact, when you take medications that require refills regularly over time, it’s always good to periodically check that your pharmacy has your most up-to-date insurance information on file. This can help you avoid potential delays in getting your prescription.

Contact 1-844-DUPIXENT (1-844-387-4936) to speak to a DUPIXENT MyWay® Nurse Educator if you have additional questions.

With the DUPIXENT MyWay Copay Card, eligible, commercially insured patients may pay as little as $0* copay per fill of DUPIXENT (maximum of $13,000 per patient per calendar year) if they meet the eligibility requirements, including:

• Have commercial insurance, including health insurance exchanges, federal employee plans, or state employee plans.
• Are a resident of the 50 United States, the District of Columbia, Puerto Rico, Guam or the USVI.
• Are prescribed DUPIXENT for an indication approved by the US Food and Drug Administration.

*Approval is not guaranteed. Program has an annual maximum of $13,000. THIS IS NOT INSURANCE. Not valid for prescriptions paid, in whole or in part, by Medicaid, Medicare, VA, DOD, TRICARE, or other federal or state programs including any state pharmaceutical assistance programs. This program is not valid where prohibited by law, taxed or restricted. DUPIXENT MyWay reserves the right to rescind, revoke, terminate, or amend this offer, eligibility, and terms of use at any time without notice. Any savings provided by the program may vary depending on patients' out-of-pocket costs. The program is intended to help patients afford DUPIXENT. Patients may have insurance plans that attempt to dilute the impact of the assistance available under the program. In those situations, the program may change its terms. Additional terms and conditions apply.

If your health plan did not accept the copay card or if you paid the copay because you were not enrolled in this program, we may be able to reimburse you in accordance with program terms.

Submit your request for reimbursement.

Through the Patient Assistance Program, eligible patients who are uninsured or whose insurance does not cover DUPIXENT could receive DUPIXENT free of charge.

Those who may qualify must be at least 18 years of age or older, a resident of the 50 United States, the District of Columbia, Puerto Rico, Guam or the USVI, and demonstrate a financial need with a total annual adjusted gross income of $100,000 or less.

The DUPIXENT MyWay team will research each patient’s situation and determine eligibility. For more information, call 1-844-DUPIXENT (1-844-387-4936),
option 1.