DUPIXENT is a prescription treatment used with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) in adults whose disease is not controlled. It is not known if DUPIXENT is safe and effective in children with CRSwNP under 18 years of age. DUPIXENT is not a steroid or immunosuppressant.Learn more about dupixent
Fill out your personalized doctor discussion guide and ask your doctor if DUPIXENT may be right for you.
Type 2 inflammation is an underlying cause of CRSwNP in 80% of patients. CRSwNP is predominantly characterized by Type 2 inflammation of the nose and paranasal sinuses. DUPIXENT blocks 2 key sources of type 2 inflammation and shrinks nasal polyps and reduces the need for surgery.Discover how DUPIXENT works
Do not use DUPIXENT if you are allergic to dupilumab or to any of the ingredients in DUPIXENT.
Before using DUPIXENT, tell your doctor about all your medical conditions, including if you:
- have eye problems.
- have a parasitic (helminth) infection.
- are scheduled to receive any vaccinations. You should not receive a "live vaccine" right before and during treatment with DUPIXENT.
- are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines; have asthma and use an asthma medicine; and have CRSwNP, and also have asthma. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine to come back.
The effectiveness and safety of DUPIXENT has been studied in the largest clinical trials to date for CRSwNP with 724 adults with uncontrolled chronic rhinosinusitis with nasal polyposis (CRSwNP).
- In both studies, DUPIXENT was proven to help patients breathe better by relieving nasal congestion and reducing the size of nasal polyps compared to placebo group.
Patients enrolled in these studies included subjects with CRSwNP regardless of whether they had prior sino-nasal surgery or treatment with, or who were ineligible to receive or were intolerant to, systemic corticosteroids in the past 2 years. Patients with chronic rhinosinusitis without nasal polyposis were not included in these trials.
DUPIXENT can cause serious side effects, including:
Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following symptoms:
- breathing problems or wheezing
- fast pulse
- general ill feeling
- swollen lymph nodes
- swelling of the face, lips, mouth, tongue, or throat
- nausea or vomiting
- fainting, dizziness, feeling lightheaded
- joint pain
- skin rash
- cramps in your stomach-area
- Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an eye exam if needed.
Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have:
- worsening shortness of breath
- persistent fever
- chest pain
- a feeling of pins and needles or numbness of your arms or legs
- Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.
The most common side effects in patients with chronic rhinosinusitis with nasal polyposis include:
- injection site reactions
- eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision
- high count of a certain white blood cell (eosinophilia)
- trouble sleeping (insomnia)
- joint pain (arthralgia)
DUPIXENT is given as an injection under the skin (subcutaneous injection) at different injection sites. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider.
Talk to your healthcare provider and see the detailed Instructions for Use that comes with DUPIXENT for information on how to prepare and inject DUPIXENT and how to properly store and throw away (dispose of) used DUPIXENT Pre-filled Syringes or DUPIXENT Pre-filled Pens prior to taking the drug.
Watch videos, learn how to administer DUPIXENT, and more.VISIT THE INJECTION SUPPORT
DUPIXENT can be injected into the thigh, stomach (except for the 2 inches around the belly button), or outer area of the upper arm (if caregiver injects). A different site should be chosen each time DUPIXENT is injected.
- Use DUPIXENT exactly as prescribed. Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it.
- Follow your healthcare provider's instructions and read the Instructions for Use for full details on preparation, administration, and disposal of your injection.
GET THE PRE-FILLED SYRINGE INSTRUCTIONS FOR USE
EMAIL YOURSELF THE 300 MG INSTRUCTIONS FOR USE
DOWNLOAD THE 300 MG
INSTRUCTIONS FOR USE
GET THE PRE-FILLED PEN INSTRUCTIONS FOR USE
EMAIL YOURSELF THE 300 MG INSTRUCTIONS FOR USE
DOWNLOAD THE 300 MG
INSTRUCTIONS FOR USE
If you miss a dose, you should administer the injection within 7 days from the missed dose and then resume the original dose schedule. If the missed dose is not administered within 7 days, you should wait until the next dose on the original schedule. Speak with your healthcare provider before making any change to your treatment regimen.Set up injection reminders
No, you should always follow your healthcare provider’s instructions for dosing and how to give injections.
Life On Dupixent
DUPIXENT should be refrigerated at 36°F to 46°F in the original carton to protect from light. If necessary, DUPIXENT may be kept at room temperature up to 77°F (25°C) for a maximum of 14 days. Do not store above 77°F (25°C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded.
Do not expose DUPIXENT to heat or direct sunlight.
Do not freeze. Do not shake.
Please refer to the DUPIXENT Instructions for Use for complete storage instructions.
Whether you are traveling or not, it’s important to store DUPIXENT in the original carton to protect it from light.
Store refrigerated at 36 °F to 46 °F (2 °C to 8 °C) in the original carton to protect from light. If necessary, DUPIXENT may be kept at room temperature up to 77 °F (25 °C) for a maximum of 14 days. Do not store above 77 °F (25 °C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded.
Access And Patient Support
Yes. You can continue to receive injection support from your doctor or our Injection Support Center, or if your doctor decides that you or your caregiver can give injections, your doctor will train you. Do not self-adminster DUPIXENT unless you have been trained by a doctor. Patients enrolled in DUPIXENT MyWay® will also have access to their Nurse Educator to help with supplemental injection training.Explore the Injection
You can use our Cost and Coverage Tool to learn more about cost options for your insurance situation. For the most accurate information regarding your cost and dispensing of DUPIXENT, speak directly with your insurance provider who knows the details of your plan.
DUPIXENT is likely dispensed differently than your other medications. DUPIXENT is an injectable medication that requires special shipping and handling. Insurance providers often require use of a specialty pharmacy instead of your local retail pharmacy. DUPIXENT MyWay® can work with your insurance provider to identify a preferred, in-network specialty pharmacy.Learn how to order DUPIXENT
Notify your pharmacy. In fact, when you take medications that require refills regularly over time, it’s always good to periodically check that your pharmacy has your most up-to-date insurance information on file. This can help you avoid potential delays in getting your prescription.
Contact 1-844-DUPIXENT (1-844-387-4936) to speak to a DUPIXENT MyWay® Nurse Educator if you have additional questions.
With the DUPIXENT MyWay Copay Card, eligible, commercially insured patients may pay as little as $0* copay per fill of DUPIXENT (maximum of $13,000 per patient per calendar year) if they meet the eligibility requirements, including:
- Have commercial insurance, including health insurance exchanges, federal employee plans, or state employee plans.
- Are a resident of the 50 United States, the District of Columbia, Puerto Rico, Guam or the USVI.
- Are prescribed DUPIXENT for an indication approved by the US Food and Drug Administration.
If your health plan did not accept the copay card or if you paid the copay because you were not enrolled in this program, we may be able to reimburse you in accordance with program terms.
Submit your request for reimbursement.Get started
Through the Patient Assistance Program, eligible patients who are uninsured or whose insurance does not cover DUPIXENT could receive DUPIXENT free of charge.
Those who may qualify must be at least 18 years of age or older, a resident of the 50 United States, the District of Columbia, Puerto Rico, Guam or the USVI, and demonstrate a financial need with a total annual adjusted gross income of $100,000 or less.
The DUPIXENT MyWay team will research each patient’s situation and determine eligibility. For more information, call 1-844-DUPIXENT (1-844-387-4936),