It is now known that nasal polyps may be caused by an underlying inflammation called type 2 inflammation. By inhibiting 2 key sources of type 2 inflammation, DUPIXENT is clinically proven to significantly reduce nasal congestion and shrink nasal polyps.
DUPIXENT is the first biologic FDA-approved in CRSwNP and is not an immunosuppressant or a steroid.
In clinical trials, patients with uncontrolled chronic rhinosinusitis with nasal polyposis (CRSwNP) who took DUPIXENT saw reduced nasal congestion and nasal polyp size at Week 24 and continued reduction at Week 52.
Patients taking DUPIXENT saw the following symptom relief in as little as 3 days:
The effectiveness and safety of DUPIXENT was studied in adults with uncontrolled chronic rhinosinusitis with nasal polyps in 2 clinical trials. Find out more about the results.
Our goal is for you or your loved one to get the most out of your visit to the doctor. Fill out our personalized discussion guide to help you have a productive conversation during your next visit.
Use this Healthgrades™ tool to easily find nearby specialists with experience in treating adults with uncontrolled chronic rhinosinusitis with nasal polyposis (CRSwNP).
Sanofi US and Regeneron do not endorse or recommend any particular physician, and search results do not include a comprehensive list of doctors in your area.
to treat people aged 6 years and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.
with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in people aged 12 years and older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems. It is not known if DUPIXENT is safe and effective in children with
with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) in adults whose disease is not controlled. It is not known if DUPIXENT is safe and effective in children with chronic rhinosinusitis with nasal polyposis under 18 years of age.
Important Safety Information
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Please see additional Important Safety Information throughout this video and adjacent links for full Prescribing Information asthma under 12 years of age.
Before starting DUPIXENT, you should talk to your doctor about all the medical conditions you have and medications you are taking.
You and your doctor should also discuss the potential benefits and risks of treatment with DUPIXENT including the most common side effects such as injection site reactions, and some serious side effects such as allergic reactions including anaphylaxis, eye problems and inflammation of your blood vessels.
JENNIFER: If you’re thinking about trying DUPIXENT, I would say, talk to your doctor, get connected with DUPIXENT MyWay, and make sure you’ve got a support system out there cheering you on. manage the disease.
RACHEL: I highly recommend getting a good physician that you can talk to that you trust, and have that open communication. Develop a good treatment plan together and advocate for yourself.
KRISTY: Know that there is DUPIXENT MyWay. There's always someone there to support you and that they're on your side. If any concerns arise or you have any problems, that there will always be someone there to help you.
CHLOE: It was so nice knowing that I could call that number anytime to talk to a nurse or whoever to give me more information to find out more about DUPIXENT, whether it was payment or how to inject or anything like that.
SUE: I don’t even think about giving myself an injection anymore. It’s just like putting on makeup or brushing your hair. It’s just there.
But everybody’s different. I know it can be kind of nerve-wracking, it’s so worth it.
JACQUE: There's help out there for you now. The advice I would give someone starting DUPIXENT is to ask all the questions that you have. Talk to your doctor.
Be optimistic. Be persistent and look forward to the possibilities that lie ahead of you with DUPIXENT.
VO: Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:
have eye problems
have a parasitic (helminth) infection
are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with DUPIXENT.
Transcript
Shari: I grew up in a very small town—one stoplight, if you blink you might miss it. Very quaint. The small-town environment lends to the type of work that I do, more one-on-one with our patients.
My name is Shari, and I’m a registered nurse with DUPIXENT MyWay.
I chose to be a nurse because I wanted to help people, and I believe that people should be in service to others.
Being a nurse for DUPIXENT MyWay is very rewarding. I really enjoy the patient interaction. I’m ready to make a difference. I’m ready to help our patients to have the confidence to proceed with their journey.
Our nurses work remotely from our homes. So, we step into our offices, we’re going into a nice relaxing environment.
When our patients call in, they get to speak to a real person, an experienced clinician who can provide them support along their journey.
We provide general product support and education, as well as supplemental injection training, and injection and refill reminder calls.
Every day is different depending on the type of calls that we have. Some of the common questions we get: “How much is it going to cost me?” “When will I get started?” “How do I take my DUPIXENT injections when I’m traveling?”
We have multiple resources available for patients. We have the ability to send out package inserts that include all the important safety information for DUPIXENT. For patients wanting a copay card, they can access that by visiting our product website at DUPIXENT.com.
One of my favorite parts of providing nursing care to our patients is being able to walk them through their journey, hold their hand through the process, just to give them confidence along the way, and we always want them to know that they have our support.
Laurie: I’m Laurie. I’m a registered nurse with DUPIXENT MyWay. I’ve been with DUPIXENT MyWay since the very beginning.
I give supplemental injection training to the patient and the patient’s caregiver.
When I was very young, I knew that I wanted to be a nurse. I wanted to go out and make a difference and help people.
When I get the order for the patient, I get really excited. I travel to see the patients—sometimes for hours. I make sure that I gather all of the things that I may need to help the experienced person, and then the person that’s never even touched a needle.
I think it’s very important for me as a nurse to go and teach these patients. Not only to teach them how to give themselves the medicine, but also to just come and give them encouragement, and show them kindness and patience.
When I go to see the patient, I can’t wait to travel, no matter how far it is. I have a training kit that has a training syringe in it. And that helps us so that we can practice before we do the real thing.
I can’t wait to go and meet them, and see where they are in their life, and be excited for them.
I help them to relax. Sometimes they can just take a deep breath, we’ll go slow, think about their favorite place, think about something that reminds them and makes them happy and calms them down.
I went to this patient’s house and he seemed very standoffish. You could tell that the patient was just not comfortable. He was anxious, he wouldn’t give me eye contact. So, I asked the parents, “Would it be OK if I just come back the next day?”
I think it’s very important to just be patient. Make it into their routine and let them go at their own pace. We have time. They have set aside this time for us to learn. And for me to teach.
Sometimes at the end of the training, I’ll get some questions about, “You know, we did great today, but what else? What if when you leave, I don’t know what to do and it’s time for me to give myself my injection again?” I can refer the patient to the DUPIXENT website for more resources, and there’s also a Nurse Educator phone number.
I like to go out and do this job. It’s just really neat. It’s neat to go in and get to know people.
Transcript
Let’s take a second to get situated before we begin our breathing exercise.
Find a spot where you can be still and quiet. Get into a comfortable position. This can be seated, standing, or laying down. Pause for just a moment before you begin.
Now, close your eyes and settle your mind.
Focus on your body relaxing as you settle into position. Relax your muscles; start with your toes, work upward to your arms and then your head. Transition your focus to your breath.
Slowly take a deep breath. Let your stomach expand [pause], and now your rib cage, and your chest. Pause for just a moment.
Exhale at the same pace as the inhale. Allow the breath to come steadily out of your nose until your lungs are completely empty.
Pay attention when you breathe in. First your stomach rises, then your rib cage, finally your chest. Notice each of them fall as you breathe out: chest, rib cage, stomach.
Feel your body respond as you continue to breathe.
This can be done for as long as you like. You can repeat this any time you are feeling anxious to help calm yourself.
TRANSCRIPT
VO:
DUPIXENT® (dupilumab) is a prescription medicine used to treat people aged 6 years and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.
Important Safety Information
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Please see additional Important Safety Information throughout this video and adjacent links for Full Prescribing Information.
Before starting DUPIXENT, you should talk to your doctor about all the medical conditions you have or medications you are taking.
You and your doctor should also discuss the potential benefits and risks of treatment with DUPIXENT including the most common side effects such as injection site reactions and some serious side effects such as allergic reactions, including anaphylaxis, and eye problems.
There is no cure for atopic dermatitis. DUPIXENT can help reduce the signs and symptoms of eczema. Patients’ individual results with DUPIXENT may vary.
MAX:
I prefer self-injection just because I feel like it’s more controlled when I do it.
ANA:
Max had his initial dose of 2 injections under the skin at the doctor’s office. She gave him one injection, and she taught him how to self-inject the second. I thought that we would go back there every 2 weeks to have the injection administered, but he picked it up, and he was very comfortable doing it, and he’s been self-injecting at home ever since.
ANA:
I think it’s great that he can self-inject. It’s great that he can do it at home. We have a scheduled time that he does it. But... I can’t even look.
MAX:
She doesn’t handle it very well. She gets really anxious when I’m doing it.
ANA:
I, myself, am not comfortable with needles, and I – you know, maybe it’s because it’s my son – I still get queasy, and I have to look away. I can’t, but he is ok.
Important Safety Information
and Indications
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:
have eye problems.
have a parasitic (helminth) infection.
are scheduled to receive any vaccinations. You should not receive a “live vaccine” right before and during treatment with DUPIXENT.
are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.
Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines; have asthma and use an asthma medicine; or have atopic dermatitis, CRSwNP, or EoE, and also have asthma. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.
DUPIXENT can cause serious side effects, including:
Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an exam if needed.
Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.
The most common side effects include:
Atopic dermatitis: injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, cold sores in your mouth or on your lips, and high count of a certain white blood cell (eosinophilia).
Asthma: injection site reactions, pain in the throat (oropharyngeal pain), high count of a certain white blood cell (eosinophilia), and parasitic (helminth) infections.
Chronic rhinosinusitis with nasal polyposis: injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, high count of a certain white blood cell (eosinophilia), trouble sleeping (insomnia), toothache, gastritis, and joint pain (arthralgia).
Eosinophilic esophagitis: injection site reactions, upper respiratory tract infections, cold sores in your mouth or on your lips, and joint pain (arthralgia).
Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider. In children 12 years of age and older, it’s recommended DUPIXENT be administered by or under supervision of an adult. In children under 12 years of age, DUPIXENT should be given by a caregiver.
to treat adults and children 6 months of age and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 months of age.
with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in adults and children 6 years of age and older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems. It is not known if DUPIXENT is safe and effective in children with asthma under 6 years of age.
with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) in adults whose disease is not controlled. It is not known if DUPIXENT is safe and effective in children with chronic rhinosinusitis with nasal polyposis under 18 years of age.
to treat adults and children 12 years of age and older, who weigh at least 88 pounds (40 kg), with eosinophilic esophagitis (EoE). It is not known if DUPIXENT is safe and effective in children with eosinophilic esophagitis under 12 years of age and who weigh at least 88 pounds (40 kg).
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