DUPIXENT WAS STUDIED IN ONE OF THE LARGEST CRSwNP
BIOLOGICS TRIAL PROGRAMS TO DATE

Results showed improvement in key areas for CRSwNP patients

These trials included 724 adults with uncontrolled chronic rhinosinusitis with nasal polyposis (CRSwNP).

Reduced nasal congestion by as
much as 50%*

Improved the ability to smell in as little as 3 days

Significant reduction
in nasal polyp size

83% fewer patients required
nasal polyp surgery†

The most common side effects include:

  • Injection site reactions
  • Eye and eyelid inflammation, including
    redness, swelling, and itching
  • High count of a certain white blood
    cell (eosinophilia)
  • Trouble sleeping (insomnia)
  • Toothache
  • Gastritis
  • Joint pain (arthralgia)

View the possible side effects of DUPIXENT in patients with uncontrolled chronic rhinosinusitis with nasal polyposis.

*For patients on DUPIXENT 300 mg in a 24-week and a 52-week clinical trial vs 17% for placebo group.

†Compared to placebo + standard of care (SOC).

ROAD TO RELIEF

Hear from real patients and discover the benefits and results of DUPIXENT for nasal polyps treatment.

Using DUPIXENT

KATHY:

Okay. So, the card reads, what has your experience been using DUPIXENT? Mark, why don't you kick us off?

MARK:

Thanks, Kathy. When I started using DUPIXENT, I was on the verge of getting another surgery. I really didn't want to have to do that. I didn't mind when I heard DUPIXENT was an injection under the skin, and that I would be able to receive training on how to do it at home. After training, my wife handled my first few injections until I was comfortable enough to do it myself. Self-injecting was easier than I had expected.

MARK:

Before I started DUPIXENT, I told my doctor about all the medical conditions I had and medications I was taking. My doctor and I talked about the potential benefits and risks of treatment including the most common side effects, such as injection site reactions, and some serious side effects, including allergic reactions that can sometimes be severe, eye problems, inflammation of your blood vessels, and joint aches and pain.

MARK:

After a few weeks into my DUPIXENT treatment, I could smell some things. My doctors were pleased with my progress, but I know this is just my experience, and everyone's experience with DUPIXENT is different. Martin, what was it like for you?

MARTIN:

I was hesitant to add another medication to my routine at first. But after learning that the injections were given every other week, I was more confident that DUPIXENT could be right for me. I talked with my doctor. I did my research. And together, we decided to move forward with the treatment.

After my doctor taught me how to selfinject, a Dupixent MyWay nurse educator came by, she came to my house.

After the first few injections, I noticed that when I drove to work, I didn't have to put that tissue up in my nose anymore like before.

KATHY:

Well, I'm the outlier from you two guys. I'm still not self-injecting yet. I don't live that far from my doctor's office. So, I put it on the calendar just like you do. It comes to the house every couple of weeks. I take it out in advance. And then I just drive up to my doctor's office. My nurse gives my shot, and I'm—and I'm done.

A few weeks after my first injection, I was in my kitchen making coffee, and I realized I could actually smell it. Now, I always try to appreciate being able to smell in the moment.

MARTIN:

I completely agree about enjoying the moment more. I even get reminders, you know, from DUPIXENT that I can add to my calendar reminding me of my injections.

MARK:

I like to set a reminder on my phone for dosing days. That way, I always know when to take DUPIXENT. I come home, take it out of the fridge, put it on the counter. We have dinner and then five minutes—it takes me five minutes to do the injection after dinner. So, for me, even though it seemed like it was going to be easy, it was a little bit challenging, but the training really helped. My family helped me out. And then I was finally able to do it myself, and now everything goes well.

And I'm with Martin. I really take in the moments with my family and friends with so much more gratitude.

Important Safety Information
and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have eye problems.
  • have a parasitic (helminth) infection.
  • are scheduled to receive any vaccinations. You should not receive a “live vaccine” right before and during treatment with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or if you have CRSwNP and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
  • Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an eye exam if needed.
  • Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, or a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
  • Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects in patients with chronic rhinosinusitis with nasal polyposis include injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, high count of a certain white blood cell (eosinophilia), trouble sleeping (insomnia), toothache, gastritis and joint pain (arthralgia).

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) in adults whose disease is not controlled. It is not known if DUPIXENT is safe and effective in children with chronic rhinosinusitis with nasal polyposis under 18 years of age.

HAVE A PRODUCTIVE CONVERSATION
WITH YOUR DOCTOR

Personalize your doctor discussion guide

Our goal is for you or your loved one to get the most out of your visit to the doctor. Use our doctor discussion guide to help personalize your next visit.

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Less Nasal Polyps. More You.

With DUPIXENT, you can do more of what matters most

In clinical studies, utilizing a symptom measurement tool, people taking DUPIXENT saw a meaningful improvement in their nasal polyps symptoms, which included, but were not limited to:

  • Nasal blockage
  • Facial pain/pressure
  • Difficulty falling asleep
  • Fatigue
  • Decreased sense of smell/taste

The relationship between DUPIXENT and its effect on individual symptoms was studied by a multi-symptom questionnaire, but not definitively proven. Ask your doctor how DUPIXENT may help.

Learn more about
nasal polyps

Find a specialist who treats Nasal Polyps

Sometimes your doctor may need to partner with a specialist in diagnosing and treating your CRSwNP. Your nasal polyps specialists have access to tools your provider may not have.

Find a nasal polyps specialist

The DUPIXENT MyWay® Copay Card may help eligible patients cover the out-of-pocket cost of DUPIXENT. Terms & Restrictions Apply.

check copay card
eligibility

FREQUENTLY ASKED QUESTIONS

The effectiveness and safety of DUPIXENT has been studied in the largest clinical trials to date for CRSwNP with 724 adults with uncontrolled chronic rhinosinusitis with nasal polyposis (CRSwNP).

  • In both studies, DUPIXENT was proven to help patients breathe better by relieving nasal congestion and reducing the size of nasal polyps compared to placebo group.

Patients enrolled in these studies included subjects with CRSwNP regardless of whether they had prior sino-nasal surgery or treatment with, or who were ineligible to receive or were intolerant to, systemic corticosteroids in the past 2 years. Patients with chronic rhinosinusitis without nasal polyposis were not included in these trials.

In clinical trials, DUPIXENT reduced nasal congestion and nasal polyp size in patients with uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP).

In clinical studies, utilizing a symptom measurement tool, people taking DUPIXENT saw less nasal congestion in as little as 2 days. Learn more about these trials and how DUPIXENT may help treat your symptoms.

In clinical trials, DUPIXENT reduced nasal congestion and nasal polyp size in patients with uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) and improved the ability to smell.

In clinical studies, utilizing a symptom measurement tool, people taking DUPIXENT saw an improved ability to smell in as little as 3 days.