How DUPIXENT Works

The First-of-Its-Kind Asthma Treatment

By blocking two key sources of Type 2 inflammation in the lungs, DUPIXENT
helps prevent asthma attacks and reduce asthma symptoms to help you or your
child DU MORE.

Why a Biologic?

DUPIXENT is a biologic-a type of medication that is processed in the body differently than oral medications (pills), or steroids. In order to be effective, and work properly, biologics are injectable medicines.

Unlike oral steroids, DUPIXENT doesn't broadly suppress the immune system. Take advantage of resources and support materials for taking and giving DUPIXENT in the Injection Support Center.

BETTER BREATHING.
LESS ORAL STEROIDS.

While oral steroids are helpful when prescribed, there is some medical concern over long-term use: mood changes, weight gain, diabetes, and vision problems.

Managing persistent, moderate-to-severe asthma is not easy. But adding DUPIXENT may help.

I went back to my doctor and
said,
"There's got to be
something different."
And that's
when he said, "I have heard
of
this drug called DUPIXENT."

- Pamela, DUPIXENT MyWay®
Patient Ambassador

Individual results may vary.

Watch Pam's story

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Hear Sharron and Rachel discuss their asthma
and how DUPIXENT has fared as a treatment option.

Transcript

VO:

DUPIXENT is a prescription medicine used with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in people aged 6 years and older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems. It is not known if DUPIXENT is safe and effective in children with asthma under 6 years of age.

Important Safety Information

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Please see additional Important Safety Information throughout this video and adjacent links for full Prescribing Information.

Individual results with DUPIXENT may vary.

RACHEL: It's really important to me to take DUPIXENT as directed by my doctor. I make it a priority. My severe asthma is something I need to keep controlled.It's not going away. It's something I live with, and I need to manage it.

SHARRON: I understand that my severe asthma is a chronic condition, there will always be underlying inflammation, and that my severe asthma will never quit and neither can I.

RACHEL: I feel motivated to stay on my treatment schedule, because I know what it feels like not to be able to breathe well, and I want to do everything I can to help avoid being in that situation.

SHARRON: What motivates me to stay on treatment is knowing that my current treatment plan is working.With DUPIXENT I’m able to do more of what I want to do and with less asthma.

RACHEL: Having a routine has definitely helped me stay on track. I take my DUPIXENT every two weeks. It’s a system I’m comfortable with.

SHARRON: So,I have a DUPIXENT reminder on my calendar and an alarm set on my phone. It’s scheduled for every two weeks and it’s like a ritual for me. It is how I take care of myself.

RACHEL: When I first started out on DUPIXENT, the DUPIXENT MyWay® patient support program was really helpful.They are there to help you answer questions about DUPIXENT. They can help you set up reminders to start and maintain a routine. But remember your doctor is always the best source of information.

SHARRON: My doctor recommended that I reach out to DUPIXENT MyWay after he wrote the prescription. I’m so glad he did! They’ve been a tremendous resource for me and it’s good to know that I can reach out to them.

RACHEL: Before I started DUPIXENT, I told my doctor about all the medical conditions I had and the medications I was taking.

SHARRON: My doctor and I went over the potential benefits and risks of treatment, including the most common side effects such as injection site reactions.

RACHEL: We also talked about some of the serious side effects such as allergic reactions, including anaphylaxis, and inflammation of your blood vessels.

SHARRON: Over time, I’ve definitely gotten more used to taking DUPIXENT. It’s a part of my life just like going to the doctor.

RACHEL: I am comfortable taking DUPIXENT every two weeks. I know that it helps control my asthma and I feel that it's helping prevent me from another asthma attack. It’s what my doctor and I decided I need to do.

VO:

Important Safety
Information and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have a parasitic (helminth) infection
  • are scheduled to receive any vaccinations. You should not receive a "live vaccine" if you are treated with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions (hypersensitivity), including a severe reaction known as anaphylaxis. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following symptoms: breathing problems, fever, general ill feeling, swollen lymph nodes, swelling of the face, mouth and tongue, hives, itching, fainting, dizziness, feeling lightheaded (low blood pressure), joint pain, or skin rash.
  • Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, shortness of breath, persistent fever, chest pain, or a feeling of pins and needles or numbness of your arms or legs.

The most common side effects in patients with asthma include injection site reactions, pain in the throat (oropharyngeal pain), high count of a certain white blood cell (eosinophilia), and parasitic (helminth) infections.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider. In children 12 years of age and older, it’s recommended DUPIXENT be administered by or under supervision of an adult. In children under 12 years of age, DUPIXENT should be given by a caregiver.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in people aged 6 years and older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems. It is not known if DUPIXENT is safe and effective in children with asthma under 6 years of age.