A FIRST-OF-ITS-KIND ASTHMA TREATMENT

Explore the benefits of DUPIXENT

HOW IT HELPS

DUPIXENT was shown to help improve
lung function. It was also shown to help
reduce or completely eliminate oral steroid
use in adults and adolescents, and reduce
oral steroid bursts in children.

TARGETING A SOURCE

By blocking two key sources of Type 2
inflammation in the lungs, DUPIXENT helps
prevent asthma attacks and reduce asthma
symptoms to help you or your child DU MORE.

Not an inhaler, Not a steroid

DUPIXENT is a prescription biologic
medication that targets an underlying cause
of asthma in the lungs.

A BIOLOGIC MAY BE RIGHT FOR YOU

Learn how DUPIXENT works for asthma.

DUPIXENT is a biologic—an injectable type of medication
that is processed in the body differently than oral
medications (pills) or steroids. Today, different biologics
are used to treat many conditions you may be familiar with.

While oral steroids are helpful when prescribed, there is some
medical concern over long-term use: mood changes,
weight gain, diabetes, and vision problems.

A Look Inside: How
DUPIXENT Works

Let Pixi walk through it
with you in the video

Learn:

  • How DUPIXENT works with your body to fight
    asthma symptoms
  • What Type 2 inflammation is
  • Why this inflammation may play a role in these
    unwanted symptoms
  • How you can reduce asthma attacks or
    reduce or eliminate oral steroid use
 

Transcript

A LOOK INSIDE: THE SCIENCE OF DUPIXENT

Please stay tuned for additional Important Safety Information.

Hi there! I’m Pixi, and I help people learn about DUPIXENT.

Today, I’d like to help you understand how DUPIXENT works in your body to improve lung function so you can breathe better in as little as two weeks.

Let’s use an analogy. It might be helpful to think of your asthma symptoms like spam calls.

Both are unwanted, persistent, and can disrupt your daily life.

Meet Mike, just an average cell phone that’s going to help us with this analogy.

He’s trying to relax when...
Poor Mike!

Unwanted interruptions can make mornings tough.

And Mike’s constant spam calls make simple activities, such as getting a good start to the day, walking in the park, and meeting up with friends harder.

Just like your asthma symptoms can make the everyday things you want to do feel like “uphill” tasks.

Frankly, it’s exhausting!

Right now, Mike has no way of blocking these unwanted spam calls.

He needs a spam filter!

Similarly, you may have no way of blocking the unwanted signals in your lungs that can cause asthma symptoms.

See, you may have Type 2 inflammation. 8 out of 10 people with asthma do!

It means there’s a constant underlying inflammation in your lungs caused by immune cells sending out too many inflammatory signals.

All this extra signaling causes the muscles in the lungs to contract and produce too much mucus, narrowing your airways and reducing air flow.

Unlike oral steroids, DUPIXENT targets an underlying source of this inflammation.

It works by attaching to certain proteins on immune cells to block some of the inflammatory signals that contribute to asthma.

So just like adding a spam filter could help Mike reduce his spam calls, adding DUPIXENT can help you reduce your asthma symptoms.

In fact, DUPIXENT was proven to help reduce asthma attacks by up to 81%.

And in a study of people who needed oral steroids, 86% of people reduced or eliminated their oral steroid dose.

The most common side effects in patients with asthma include injection site reactions, high count of a certain white blood cell (eosinophilia), pain in the throat (oropharyngeal pain), and parasitic (helminth) infections.

With his newly-installed spam filter, Mike gets fewer spam calls and can do more of what he loves. What could you do with less asthma?

If your current therapy isn’t doing enough, talk to your doctor about DUPIXENT, the first-of-its-kind asthma treatment proven to help patients breathe better in as little as two weeks. Stay tuned for additional Important Safety Information.

Want more information on DUPIXENT? Find me anytime at DUPIXENT.com.

Important Safety
Information and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have a parasitic (helminth) infection
  • are scheduled to receive any vaccinations. You should not receive a "live vaccine" right before and during treatment with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
  • Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
  • Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects in patients with asthma include injection site reactions, high count of a certain white blood cell (eosinophilia), pain in the throat (oropharyngeal pain), and parasitic (helminth) infections.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider. In children 12 years of age and older, it’s recommended DUPIXENT be administered by or under supervision of an adult. In children 6 to less than 12 years of age, DUPIXENT should be given by a caregiver.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in adults and children 6 years of age and older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems. It is not known if DUPIXENT is safe and effective in children with asthma under 6 years of age.

BENEFITS WITH EVERY BREATH

Explore the clinical trial results of DUPIXENT in patients ages 12+ years old and children 6 to 11 years old with moderate-to-severe eosinophilic or oral steroid dependent asthma.

Results in patients
12+ Years
Results in patients
6-11 Years

THE PATIENT BROCHURE

Download or print out the patient brochure in English or Spanish to see DUPIXENT results, learn more about how DUPIXENT is taken, and so much more.

Get the DUPIXENT patient brochure

DOWNLOAD THE BROCHURE

Get the Spanish patient brochure

DOWNLOAD THE BROCHURE

CONVERSATIONS WITH
YOUR DOCTOR

Learn what it means
to be a partner in your
treatment journey

Patients can take part in treatment decisions. Listen to a patient advocate for themselves with their doctor.

Additional Video Resources

Learn the importance of staying on track with your DUPIXENT medication as well as the role you and your doctor can play in guiding your treatment journey with these video resources.

LIFE ON DUPIXENT

Transcript

RACHEL: It's really important to me to take DUPIXENT as directed by my doctor. I make it a priority. My severe asthma is something I need to keep controlled. It's not going away. It's something I live with, and I need to manage it.

SHARRON: I understand that my severe asthma is a chronic condition, there will always be underlying inflammation, and that my severe asthma will never quit and neither can I.

RACHEL: I feel motivated to stay on my treatment schedule, because I know what it feels like not to be able to breathe well, and I want to do everything I can to help avoid being in that situation.

SHARRON: What motivates me to stay on treatment is knowing that my current treatment plan is working. With DUPIXENT I’m able to do more of what I want to do and with less asthma.

RACHEL: Having a routine has definitely helped me stay on track. I take my DUPIXENT every two weeks. It’s a system I’m comfortable with.

SHARRON: So, I have a DUPIXENT reminder on my calendar and an alarm set on my phone. It’s scheduled for every two weeks, and it’s like a ritual for me. It is how I take care of myself.

RACHEL: When I first started out on DUPIXENT, the DUPIXENT MyWay® patient support program was really helpful. They are there to help you answer questions about DUPIXENT. They can help you set up reminders to start and maintain a routine. But remember, your doctor is always the best source of information.

SHARRON: My doctor recommended that I reach out to DUPIXENT MyWay after he wrote the prescription. I’m so glad he did! They’ve been a tremendous resource for me, and it’s good to know that I can reach out to them.

SHARRON: Before I started DUPIXENT, I told my doctor about all the medical conditions I had and medications I was taking.

RACHEL: My doctor and I talked about the potential benefits and risks of treatment, including the most common side effects such as injection site reactions, and some serious side effects including allergic reactions that can sometimes be severe, inflammation of your blood vessels, and joint aches and pain.

SHARRON: Over time, I’ve definitely gotten more used to taking DUPIXENT. It’s a part of my life, just like going to the doctor.

RACHEL: I am comfortable taking DUPIXENT every two weeks. I know that it helps control my asthma, and I feel that it's helping prevent me from another asthma attack. It’s what my doctor and I decided I need to do.

VO:

Important Safety
Information and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have a parasitic (helminth) infection
  • are scheduled to receive any vaccinations. You should not receive a "live vaccine" right before and during treatment with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
  • Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
  • Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects in patients with asthma include injection site reactions, high count of a certain white blood cell (eosinophilia), pain in the throat (oropharyngeal pain), and parasitic (helminth) infections.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider. In children 12 years of age and older, it’s recommended DUPIXENT be administered by or under supervision of an adult. In children 6 to less than 12 years of age, DUPIXENT should be given by a caregiver.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in adults and children 6 years of age and older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems. It is not known if DUPIXENT is safe and effective in children with asthma under 6 years of age.

YOUR DOCTOR
CAN HELP

Transcript

SHARRON: My severe asthma was out of control most of my life, probably about 20 years. I didn’t always know when I was gonna have an asthma attack, and that’s part of the challenging part of living with severe asthma.

I tried prescription inhalers, nebulizers, oral corticosteroids.

These treatments were just not providing the relief that I was looking for.

When my doctor suggested DUPIXENT as an add-on maintenance treatment, I wanted to know everything. I was at a point where I was ready—we both felt that I was ready.

DR. SPORTER: I see a lot of patients like Sharron who have moderate-to-severe eosinophilic asthma that’s not controlled despite inhalers, or they have oral steroiddependent asthma.

Their immune system is in overdrive. It's hyperactive, and when they have an asthma attack, that hyperactivity is causing them to have tight airways. For these patients, I recommend DUPIXENT.

DUPIXENT works in your immune system to help dial down that overreaction, and it's not an immunosuppressant. DUPIXENT is a biologic medication that works differently by targeting the underlying source of that inflammation.

SHARRON: I didn't know how I would respond to DUPIXENT, but I was hopeful that it could help me. At that point, I had to do something to take charge of my severe asthma, so I said, "Let's do it.” I felt that my doctor really understood my asthma, and I trusted his opinion.

DR. SPORTER: The first thing I want to do is understand their questions about DUPIXENT, and I want to make sure that I answer them and give them the opportunity to get the information they need.

I assure them that I have experience treating patients with DUPIXENT, and that patients in the clinical trials saw positive results. Over time, patients on DUPIXENT may experience decreased asthma symptoms and improved lung function. Of course, everyone's experience on DUPIXENT is different.

SHARRON: My doctor was straight with me. He kept my expectations in check, and he said, "Let's try it and see how this goes."

SHARRON: Before I started DUPIXENT, I told my doctor about all the medical conditions I had and medications I was taking.

My doctor and I talked about the potential benefits and risks of treatment, including the most common side effects such as injection site reactions, and some serious side effects including allergic reactions that can sometimes be severe, inflammation of your blood vessels, and joint aches and pain.

DR. SPORTER: Every so often, I have a patient who's on the fence about DUPIXENT because it's an injectable medication.<./p>

I explain that DUPIXENT is a biologic medication. It works different from oral medications or steroids. Most biologic medications are injections. I let them know that I'll train them to self-inject.

For my patients who aren’t comfortable injecting with a syringe, I let them know that there’s a pre-filled single-dose pen.

SHARRON: My doctor told me that DUPIXENT was going to be an injectable. That it would involve a syringe. So, when he first told me that, I was a little nervous because I have a little fear of needles.

My doctor and I spent some time talking about the self-injection. He referred me to the self-injection video on DUPIXENT.com.

He also said there was a team at DUPIXENT MyWay who could provide supplemental injection training to help me become more familiar with self-injecting. I felt more at ease, and I also felt that the support was there if I needed it.

DR. SPORTER: I can tell you, as a physician, it feels great to see patients like Sharron come in and have improved symptoms on DUPIXENT. It's important to keep in mind that a patient's individual results with DUPIXENT may vary.

SHARRON: I'm so glad my doctor and I made the decision to start DUPIXENT.

VO:

Important Safety
Information and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have a parasitic (helminth) infection
  • are scheduled to receive any vaccinations. You should not receive a "live vaccine" right before and during treatment with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
  • Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
  • Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects in patients with asthma include injection site reactions, high count of a certain white blood cell (eosinophilia), pain in the throat (oropharyngeal pain), and parasitic (helminth) infections.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider. In children 12 years of age and older, it’s recommended DUPIXENT be administered by or under supervision of an adult. In children 6 to less than 12 years of age, DUPIXENT should be given by a caregiver.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in adults and children 6 years of age and older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems. It is not known if DUPIXENT is safe and effective in children with asthma under 6 years of age.

FIND A NEARBY SPECIALIST WHO TREATS ASTHMA

Use this HealthgradesTM tool to easily find nearby specialists with experience in treating children, teens, and adults with uncontrolled moderate-to-severe eosinophilic or oral steroid dependent asthma.

Sanofi US and Regeneron do not endorse or recommend any particular physician, and search results do not include a comprehensive list of doctors in your area.

frequently asked questions

Asthma is a chronic inflammatory condition and 8 out of 10 patients with asthma have a specific kind of inflammation called type 2 inflammation. DUPIXENT blocks 2 of the key sources of type 2 inflammation in your lungs to help prevent asthma attacks and reduce asthma symptoms. DUPIXENT is a not a steroid or inhaler.

Learn more about
uncontrolled asthma

Do not use DUPIXENT if you are allergic to dupilumab or to any of the ingredients in DUPIXENT.

Inactive ingredients: L-arginine hydrochloride, L-histidine, polysorbate 80, sodium acetate, sucrose, and water for injection.

Before using DUPIXENT, tell your doctor about all your medical conditions, including if you:

  • have a parasitic (helminth) infection
  • are scheduled to receive any vaccinations. You should not receive a "live vaccine" right before and during treatment with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine to come back.

DUPIXENT was studied in the VENTURE trial, where 86% of patients reduced or eliminated their oral steroid dose with DUPIXENT 300 mg + Standard of Care (SOC) vs 68% with placebo + SOC.

Do not stop taking your corticosteroid medicines unless instructed by your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine to come back.

The most common side effects include injection site reactions, high count of a certain white blood cell (eosinophilia), and pain in the throat (oropharyngeal pain).

View the possible side effects of DUPIXENT in patients with moderate-to-severe eosinophilic or oral corticosteroid dependent asthma below.

View the possible side effects