How DUPIXENT® (dupilumab) is Taken for CRSwNP

what you should know

DUPIXENT can be given by your doctor in a clinic or self-administered at home. If your healthcare provider decides that you or a caregiver can give DUPIXENT injections, you or your caregiver should receive training on the right way to prepare and inject DUPIXENT.

In addition to the training from your doctor, explore the resources available in the Injection Support Center that may help you become more comfortable with injections.

RECOMMENDED DOSING
FOR DUPIXENT

The recommended dose is specified in the table below. Use DUPIXENT exactly as prescribed by your healthcare provider.

Talk to your healthcare provider, and download the detailed Instructions for Use for information on how to prepare and inject DUPIXENT and how to properly store and dispose of used DUPIXENT Pre-filled Syringes or Pre-filled Pens. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider.

Patients

Dosage

Frequency

Adults 18+

300 mg

Every other
week

If your dose schedule is every other week and you miss a dose of DUPIXENT: Give the DUPIXENT injection within 7 days from the missed dose, then continue with your original schedule. If the missed dose is not given within 7 days, wait until the next scheduled dose to give your DUPIXENT injection.

how to take dupixent

In addition to what you’ve been shown by your doctor, use the Injection Support Center to get resources and support materials for taking—and giving—DUPIXENT.

Supplemental injection video tutorials

Downloadable Instructions for Use

Plus, get testimonials from real patients and mindful breathing techniques.

TWO WAYS TO TAKE DUPIXENT

Pre-filled Pen

Hear and see when your dose is being delivered
Hidden needle

Pre-filled Syringe

Needle shield for safety
Full-dose delivery when plunger is completely depressed

Nurse Educators Are Here to Help

In addition to the training from your doctor, a DUPIXENT MyWay Nurse Educator can provide supplemental injection training, either online, over the phone, or in-person with a training kit and syringe for practice.

For more information, dial
1‑844‑DUPIXENT (1-844-387-4936), option 1
Monday-Friday, 8 am - 9 pm EST

Important Safety
Information and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT^®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

have eye problems.
have a parasitic (helminth) infection.
are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with DUPIXENT.
are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
- There is a pregnancy exposure registry for women who take DUPIXENT during pregnancy to collect information about the health of you and your baby. Your healthcare provider can enroll you or you may enroll yourself. To get more information about the registry call 1-877-311-8972 or go to https://mothertobaby.org/ongoing-study/dupixent/.
are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or if you have CRSwNP and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

Allergic reactions (hypersensitivity), including a severe reaction known as anaphylaxis. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following symptoms: breathing problems, fever, general ill feeling, swollen lymph nodes, swelling of the face, mouth and tongue, hives, itching, fainting, dizziness, feeling lightheaded (low blood pressure), joint pain, or skin rash.
Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision.
Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, shortness of breath, persistent fever, chest pain, or a feeling of pins and needles or numbness of your arms or legs.

The most common side effects in patients with chronic rhinosinusitis with nasal polyposis include injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, high count of a certain white blood cell (eosinophilia), trouble sleeping (insomnia), toothache, gastritis and joint pain (arthralgia).

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed. Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it. DUPIXENT is an injection given under the skin (subcutaneous injection). If your healthcare provider decides that you or a caregiver can give DUPIXENT injections, you or your caregiver should receive training on the right way to prepare and inject DUPIXENT. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) in adults whose disease is not controlled. It is not known if DUPIXENT is safe and effective in children with chronic rhinosinusitis with nasal polyposis under 18 years of age.

HOW DUPIXENT IS TAKEN

THE INNOVATIVE TREATMENT WITHOUT SURGERY

what you should know

RECOMMENDED DOSING
FOR DUPIXENT

how to take dupixent

TWO WAYS TO TAKE DUPIXENT

Nurse Educators Are Here to Help

Important Safety
Information and Indication

Indication

HOW DUPIXENT IS TAKEN

THE INNOVATIVE TREATMENT WITHOUT SURGERY

what you should know

RECOMMENDED DOSING FOR DUPIXENT

how to take dupixent

TWO WAYS TO TAKE DUPIXENT

Nurse Educators Are Here to Help

Important Safety Information and Indication

Indication

RECOMMENDED DOSING
FOR DUPIXENT

Important Safety
Information and Indication