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PRE-FILLED PEN INJECTION SUPPORT

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HOW TO INJECT DUPIXENT
WITH A PRE-FILLED PEN
Dupixent® (dupilumab) Pre-Filled Pen (200 mg Or 300 mg) For Ages 2+ Years

  • Talk to your/your child's doctor, and download the Instructions for Use for information on preparing, injecting, proper storage, and disposal of used DUPIXENT Pre-filled Syringes or Pre-filled Pens.
  • If your doctor decides you/your caregiver can give the DUPIXENT injections, you/your caregiver should receive proper training on preparing and injecting.
  • Do not try to inject DUPIXENT until you've been properly trained by your healthcare provider.
  • In children 12 years of age and older, it is recommended that DUPIXENT be administered by or under supervision of an adult. In children 2 years to less than 12 years of age, DUPIXENT should be given by a caregiver.

Use DUPIXENT exactly as prescribed by your doctor. Your doctor will tell you how much DUPIXENT to inject and how often to inject it. DUPIXENT is available as a single dose in a pre-filled syringe (200 mg or 300 mg) with needle shield, or single-dose pre-filled pen (200 mg or 300 mg) for ages 2+ years.

Watch Full Demonstration

The pre-filled pen how-to video below is divided into chapters to help you navigate information and
injection steps. Watch the video in full or select a specific chapter from the list on the right.
 

See step-by-step instructions

1 Gather Supplies

Find a clean, flat work surface. Make sure you have the following supplies:

  • DUPIXENT Pre-filled Pen
  • 1 alcohol wipe*
  • 1 cotton ball or gauze*
  • Sharps Disposal Container* (See Step 13)

*Items not included in the carton

2 Check the Pen
  • Do not use the DUPIXENT Pre-filled Pen if it has been damaged.
  • Do not use the DUPIXENT Pre-filled Pen if the Green Cap (300 mg) or Yellow Cap (200 mg) is missing or not securely attached.
  • Do not use the DUPIXENT Pre-filled Pen if the Window is yellow before use.
3 Look at the Label
  • Check to be sure that you have the correct Medicine and dose.
  • Check the expiration date.
  • Do not use the DUPIXENT Pre-filled Pen if the expiration date has passed.
4 Check the Medicine
  • Look at the Medicine through the Window: it should be clear and colorless to pale yellow.
  • Note: You may see an air bubble, this is normal.
  • Do not use the DUPIXENT Pre-filled Pen if the liquid is discolored or cloudy, or if it contains visible flakes or particles.
5 Wait Appropriate Time

Lay the DUPIXENT Pre-filled Pen on a flat surface and let it naturally warm up at room temperature less than 77°F (25°C) for at least 45 minutes for 300 mg dose or 30 minutes for 200 mg dose.

  • Do not heat the DUPIXENT Pre-filled Pen in a microwave, hot water or direct sunlight.
6 Wash Your Hands Well With Soap and Water
7 Choose An Injection Site
  • Thigh
  • Stomach except for the 2 inches (5 cm) around your belly button (navel).
  • A caregiver can also inject into the outer area of the upper arm.
  • Choose a different injection site for each injection.
  • Do not inject into skin that is tender, damaged, has bruises or scars, or into areas with visible veins.
  • Do not inject through clothes.
Human body diagram of ideal Dupixent® (dupilumab) administration sites including outer upper arms, abdomen, and thighs
8 Prepare the Injection Site
  • Clean the injection site with an alcohol wipe.
  • Let your skin dry before injecting.
  • Do not touch the injection site again or blow on it before the injection.
9 Remove Cap
  • Remove the Green Cap (300 mg) or Yellow Cap (200 mg) by pulling it straight off, as shown. Do not twist the cap off.
  • Do not remove the cap until you are ready to inject.
  • Do not press or touch the Yellow (300 mg) or Orange (200 mg) Needle Cover with your fingers. The Needle is inside.
  • Do not put the cap back on the DUPIXENT Pre-filled Pen after you have removed it.
10 Pinch Skin and Place
  • Pinch the skin before and during the injection.
    • Pinching is not needed for adults and children aged 12 years and older.
  • Hold the DUPIXENT Pre-filled Pen as shown so that you can see the Window.
  • Place the Yellow (300 mg) or Orange (200 mg) Needle Cover on your skin at approximately a 90-degree angle.
11 Press Down, Watch Window Turn Fully Yellow, Then Count to 5
  • Press and hold the DUPIXENT Pre-filled Pen firmly against your skin until you cannot see the Yellow (300 mg) or Orange (200 mg) Needle Cover.
  • There will be a “click” when the injection starts, and
  • The Window will start to turn yellow.
  • Keep pressing the DUPIXENT Pre-filled Pen against your skin and watch the window:
    • The window will turn completely yellow, and
    • You will hear a 2nd “click”.
    • Keep pressing the DUPIXENT Pre-filled Pen against your skin.
  • Keep pressing the DUPIXENT Pre-filled Pen against your skin and count to 5 to make sure you get your full dose.
12 Remove
  • After you have completed your injection pull straight up to remove DUPIXENT Pre-filled Pen from the skin. The Yellow (300 mg) or Orange (200 mg) Needle Cover will cover the needle.
  • If you see any blood at the site, lightly dab a cotton ball or gauze pad.
  • Do not rub your skin after the injection.
  • If the Window does not turn completely Yellow, remove the pen and call your healthcare provider.
  • Do not give yourself a second dose without speaking with your healthcare provider.
13 How to Dispose of (Throw Away) DUPIXENT Pre-filled Pen
  • Put your used DUPIXENT Pre-filled Pens, and Green or Yellow Caps in an FDA-cleared sharps disposal container right away after use.
  • Do not dispose of (throw away) DUPIXENT Pre-filled Pens and Caps in your household trash.
  • If you do not have an FDA-cleared sharps disposal container, you may use a household container that is:
    • Made of a heavy-duty plastic,
    • Can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
    • Upright and stable during use,
    • Leak-resistant, and
    • Properly labeled to warn of hazardous waste inside the container.
  • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used DUPIXENT Pre-filled Pens. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal.
  • Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this.
  • Do not recycle your used sharps disposal container.
  • Keep your sharps disposal container out of reach of children.

This Instructions for Use has been approved by the U.S. Food and Drug Administration.