The First and only FDA-Approved treatment for adults with PN

DUPIXENT works by specifically blocking a source of Type 2 inflammation which could contribute to PN.

An FDA-Approved Way to Treat PN- That’s A Win For Skin

DUPIXENT is a biologic that works within your body to control a source of unwanted inflammation under the surface to help keep you one step ahead of PN symptoms.

Reduces Itch

DUPIXENT can help break the intense cycle of itching.

Works Differently

DUPIXENT helps heal your skin from within, targeting a source of inflammation that may be a driver of your PN.

Not an Immunosuppressant

DUPIXENT is not a cream, immunosuppressant, or steroid.

Results you can see and feel

DUPIXENT was studied in 2 clinical trials with 311 adults with PN.


had significantly less itch at 24 weeks

(In trial 1, 60% on DUPIXENT vs 18.4% on placebo;
in trial 2, 57% on DUPIXENT vs 19.5% on placebo)

Some adults had less itch in as little as 12 weeks

(In trial 2, 37.2% on DUPIXENT vs 22% on placebo)


had skin that’s clear or almost clear of PN bumps at 24 weeks

(In trial 1, 48% on DUPIXENT vs 18.4% on placebo; in trial 2, 44.9% on DUPIXENT vs 15.9% on placebo)


had both itch improvement and skin clear or almost clear of PN bumps at 24 weeks

(In trial 1, 38.7% on DUPIXENT vs 9.3% on placebo; in trial 2, 32.1% on DUPIXENT vs 8.5% on placebo)

The most common side effects in patients with prurigo nodularis include eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, herpes virus infections, common cold symptoms (nasopharyngitis), dizziness, muscle pain, and diarrhea.

Have a Productive Conversation
With Your Doctor

Our goal is for you to get the most out of your visit to
your doctor. Download this doctor discussion guide
to help yourself have a productive conversation
during your next visit.

Download Your Guide


Looking for DUPIXENT information you can download
or print out? Download the patient brochure to have on hand.

Get the dupixent patient brochure



Your experience with DUPIXENT is unique and yours to tell, and we want to know your story. It can inspire people going through similar experiences. If selected, you may be featured in print materials, on social media, or in videos. Interested in hearing more or sharing your story?

Are you interested in sharing your journey with DUPIXENT? If so, please call 1-844-DUPIXENT (1-844-387-4936), option 5.