INJECTION SUPPORT
CENTER

INJECTION
RESOURCES

Being unfamiliar with injections or having questions around taking DUPIXENT is normal. That’s why we’ve provided resources to help after you've been trained by your healthcare provider. Watch videos on how to take DUPIXENT, hear from real patients about the injection process, and get tips and answers to frequently asked questions. And remember, it is always important to talk to your doctor.

Talk to your or your child’s healthcare professional, and download the detailed Instructions for Use for information on how to prepare and inject DUPIXENT and how to properly store and dispose of used DUPIXENT Pre-filled Syringes or DUPIXENT Pre-filled Pens. If your doctor decides that you or a caregiver can give the injections of DUPIXENT, you or your caregiver should receive training on the right way to prepare and inject DUPIXENT. Do not try and inject DUPIXENT until you have been shown the right way by your healthcare provider. In teens 12 years of age or older, it is recommended that DUPIXENT be administered by or under the supervision of an adult. DUPIXENT should be given by a caregiver in children 6-11 years of age.

HOW TO INJECT DUPIXENT

Use DUPIXENT exactly as prescribed by your doctor. Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it. DUPIXENT is available as a single-dose pre-filled syringe (200 mg or 300 mg) with needle shield or pre-filled pen (300 mg).

Select the correct option below to see the supplemental injection training video and download the Instructions for Use that match how you take DUPIXENT.

The caregiver video features a caregiver injecting an adolescent patient. DUPIXENT is not approved for patients under 18 years of age with chronic rhinosinusitis with nasal polyposis.


PRE-FILLED SYRINGE Self-Injection

Hi there. I'm Laura.

Today I'm going to show you how to properly self-inject a dose of DUPIXENT (dupilumab).

You've already learned how to self-inject with your healthcare provider.

I'm here to guide your first at-home experience.

When I first started self-injections, I found syringes really intimidating. I've gotten better at the process since then, so I want to share those steps with you today.

I'll show you: what supplies to gather, how to prep the injection area, and how to inject the dose and discard your used syringe.

If you haven't yet read the instructions for use located in your treatment packaging, pause the video and take a look.

I found it helpful to understand the plunger, syringe body, and needle cap before handling the syringe itself.

Contact your healthcare provider or the DUPIXENT MyWay® Hotline with any questions.

It's time for me to take my DUPIXENT injection. Feel free to watch me and follow along as I self-inject.

Narration

Take your medication out of the refrigerator. Never freeze your syringe.

Remove the syringe by holding the middle of the syringe body.

  • Do not use the syringe if it has been dropped on a hard surface or is damaged.
  • Do not pull off the needle cap or touch the plunger rod until you are ready to inject.
  • Do not pull back on the plunger rod at any time.
  • Keep DUPIXENT syringes and all medicines out of the reach of children.
  • If you have an unused syringe, return it to the refrigerator in the original carton to protect it from light.

Your DUPIXENT pre-filled syringe may appear different than what I am using in this video, based on the prescribed dose. If you have questions about the dosage prescribed to you, please contact your healthcare provider.

Check the label to make sure the medication inside is correct and the expiration date has not passed. If it isn't right, contact your pharmacy.

You may see an air bubble, this is normal. Do not try to get rid of any air bubbles.

The liquid inside should be clear, and colorless to pale yellow.

Do not use the syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles. Throw away, dispose of, the used DUPIXENT single-dose pre-filled syringe right away after use.

If you have any questions about whether the syringe is okay to use, please call the DUPIXENT MyWay Hotline, or your healthcare provider.

Lay the syringe on a flat surface and let it naturally warm to room temperature.

The recommended warming time for the 200mg syringe is 30 minutes, and for the 300mg syringe, it's 45 minutes.

  • Do not heat the syringe.
  • Do not put the syringe into direct sunlight.
  • Do not keep DUPIXENT at room temperature for more than 14 days. Throw away, dispose of, any syringe that has been left at room temperature for longer than 14 days.
  • Do not shake the syringe.

While you wait, gather the additional materials necessary to self-inject.

You need one cotton ball or gauze, one alcohol wipe, and a puncture resistant Sharps Disposal Container.

If you don't have a Sharps Disposal Container, call a DUPIXENT MyWay representative to request a complimentary Sharps Disposal Container.

Now, take your supplies to an area where you can sit comfortably.

When you are ready to get started, wash your hands thoroughly.

Choose your injection site. Both the stomach and thigh are acceptable, except for the two inches around your belly button.

If a caregiver gives you the injection, the outer area of the upper arm is also an option. The person giving the injection should follow the same preparation procedure.

Be sure to choose a different site each time you inject DUPIXENT.

  • Do not inject through clothes.
  • Do not inject into skin that is tender, damaged or is bruised or scarred.

Clean your skin with the alcohol wipe.

Do not touch the injection site again or blow on it before the injection. Let your skin dry before injection.

Hold the DUPIXENT syringe in the middle of the Syringe Body with the Needle pointing away from you and carefully remove the cap from the syringe.

  • Do not use if the needle cap is missing or not securely attached.
  • Do not put the needle cap back on.
  • Do not touch the needle. Inject the medicine right away after removing the Needle cap.

Pinch a fold of skin at the injection site. Pinching your skin helps the medicine go into a fatty layer, just below the skin, and not into the muscle.

Take a deep breath.

Continue to pinch, as you insert the needle completely at about a 45° angle.

Relax your pinch.

Push the plunger down slowly and steadily as far as it will go, until the syringe is empty.

You will feel some resistance. This is normal.

Lift your thumb to release the Plunger Rod until the Needle is covered by the Needle Shield and then remove the Syringe from the injection site.

Lightly press a cotton ball or gauze on the injection site if you see any blood. Do not put the Needle Cap back on.

Do not rub your skin after the injection.

You can also cover the site with a bandage.

Put your used Needles, DUPIXENT Syringes, and Needle Caps in a FDA-cleared Sharps Disposal Container right away after Use.

Do not dispose of needles, DUPIXENT Syringes, and Needle Caps in your household trash.

Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once it is full.

Do not recycle your used Sharps Disposal Container.

Do not reuse the syringe.

If you would like to practice before doing the actual injection and you have received the DUPIXENT training kit from your doctor's office, you can practice the 45° injection angle with your training syringe and the angle aid, and you could always watch the video again.

Remember, do not use the angle-aid to administer an actual injection.

Narration - On Camera Ending

Be sure to keep track of your injection date and site.

Thank you for joining me today. Remember, you can re-watch this video as often as you like to refresh your memory.

Contact your healthcare provider or the DUPIXENT MyWay Hotline with any questions or concerns.

Narration - ISI Indication

PRE-FILLED SYRINGE Caregiver Injection

MOM: Since you’re watching this video, I know you’ve already learned how to give an injection with your healthcare provider. I’m just here to help guide you through your first at-home experience.

When I first started giving injections, I found syringes really intimidating. I've gotten better at the process since then, so I wanted to share those steps with you today.

If you haven’t yet read the Instructions for Use located in your treatment packaging, pause the video and take a look. And if you have any questions along the way, don’t hesitate to reach out to your healthcare provider or the DUPIXENT MyWay hotline. They’re always there to help.

MOM: Are you ready? …OK

Are you ready?

SON: What?

MOM: Let’s show them how to properly inject a dose of DUPIXENT.

SON: Oh, sure.

MOM: First, take your medication out of the refrigerator. Never freeze your syringe.

Remove the syringe by holding the middle of the syringe body.

A few things to remember:

  • Do not use the syringe if it has been dropped on a hard surface or is damaged.
  • Do not pull off the needle cap or touch the plunger rod until you are ready to inject.
  • Do not pull back on the plunger rod at any time.
  • Keep DUPIXENT syringes and all medicines out of the reach of children.
  • If you have an unused syringe, return it to the refrigerator in the original carton to protect it from light.

Your DUPIXENT pre-filled syringe may appear different from what you see in this video, based on the prescribed dose. If you have questions about the dosage prescribed, please contact your healthcare provider.

OK, now it’s time to check the label to make sure the medication and dosage are correct and the expiration date has not passed. If it isn’t right, contact your pharmacy.

SON: Looks right to me.

MOM: Yup.

Now look at the medicine through the Viewing Window on the DUPIXENT syringe. The liquid inside should be clear and colorless to pale yellow. You may see an air bubble; this is normal. Do not try to get rid of any air bubbles.

Do not use the syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles.

Throw away, dispose of, the used DUPIXENT single-dose, pre-filled syringe right away after use.

If you have any questions about whether the syringe is OK to use, please call the DUPIXENT MyWay® hotline, or your healthcare provider.

Lay the syringe on a flat surface and let it naturally warm to room temperature. The recommended warming time for the 200mg syringe is 30 minutes, and for the 300mg syringe it's 45 minutes.

Here are a few more things to remember:

  • Do not heat the syringe.
  • Do not put the syringe into direct sunlight.
  • Do not keep DUPIXENT at room temperature for more than 14 days. Throw away any syringe that has been left at room temperature for longer than 14 days.
  • Do not shake the syringe.

While you wait, gather the additional necessary materials.

You need one cotton ball or gauze.

SON: Check.

MOM: One alcohol wipe.

SON: Check.

MOM: And a puncture-resistant sharps disposal container.

SON: Check.

MOM: If you don’t have a sharps disposal container, call a DUPIXENT MyWay representative to request a complimentary sharps disposal container.

When you are ready to get started, wash your hands thoroughly.

Now, take your supplies to an area where you can sit comfortably.

Choose your injection site. Both the stomach and thigh are acceptable, except for the two inches around the belly button. The outer area of the upper arm is also an option since you are giving the injection to someone, but not if you’re self-injecting.

Be sure to choose a different site each time you inject DUPIXENT.

  • Do not inject through clothes.
  • Do not inject into skin that is tender, damaged, bruised, or scarred.

OK, now clean the skin with the alcohol wipe.

Do not touch the injection site again or blow on it before the injection.

Once the skin is dry, hold the DUPIXENT syringe in the middle of the syringe body with the needle pointing away from you and carefully remove the cap from the syringe.

  • Do not use if the needle cap is missing or not securely attached.
  • Do not put the needle cap back on.
  • Do not touch the needle. Inject the medicine right away after removing the needle cap.

Pinch a fold of skin at the injection site. Pinching the skin helps the medicine go into a fatty layer, just below the skin, and not into the muscle.

Take a deep breath.

Continue to pinch as you insert the needle completely at about a 45° angle.

Relax your pinch.

Push the plunger down slowly and steadily as far as it will go, until the syringe is empty. You will feel some resistance. This is normal.

Lift your thumb to release the plunger rod until the needle is covered by the needle shield and then remove the syringe from the injection site.

Lightly press a cotton ball or gauze on the injection site if you see any blood. Do not put the needle cap back on, and do not rub the skin after the injection.

SON: Got it.

MOM: You can also cover the site with a bandage.

OK, now put the used DUPIXENT syringe and cap in an FDA-cleared sharps disposal container right away after use.

Do not put DUPIXENT syringes in your household trash. Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once it is full.

Do not recycle your used sharps disposal container. And do not reuse the syringe.

If you would like to practice before doing the actual injection and you have received the DUPIXENT training kit from your doctor's office, you can practice the 45° injection angle with the training syringe and the angle aid. Do not use the angle aid to administer an actual injection.

Finally, always be sure to keep track of the injection date and site.

Well, now you know how to give a dose of DUPIXENT. If you follow these steps, you’ll be a pro in no time.

Feel free to rewatch this video as many times as you’d like. And again, reach out to your healthcare provider or call the DUPIXENT MyWay hotline if you have any questions.

Well, that wasn’t so bad, was it?

SON: What?

PRE-FILLED SYRINGE INSTRUCTIONS

  1. Remove

    Remove the DUPIXENT Syringe from the carton by holding the middle of the Syringe Body.

    • Do not pull off the Needle Cap until you are ready to inject.
    • Do not use the DUPIXENT Syringe if it has been dropped on a hard surface or damaged.
  2. Prepare

    Ensure you have the following:

    • DUPIXENT Pre-filled Syringe
    • 1 alcohol wipe*
    • 1 cotton ball or gauze*
    • Sharps Disposal Container* (See Step 13)

    *Items not included in the carton

  3. Check

    When you receive your DUPIXENT Syringes, always check to see that:

    • You have the correct medicine and dose.
    • The expiration date on the Single-Dose Pre-filled Syringe has not passed.
      • Do not use the DUPIXENT Syringe if the expiration date has passed.
  4. Inspect
    • Look at the medicine through the Viewing Window on the DUPIXENT Syringe: Check to see if the liquid is clear and colorless to pale yellow.
    • Note: You may see an air bubble, this is normal.
      • Do not use the DUPIXENT Syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles.
  5. Wait Appropriate Time

    Lay the DUPIXENT Syringe on a flat surface and let it naturally warm to room temperature for at least 45 minutes for 300 mg dose or 30 minutes for 200 mg dose.

    • Do not heat the DUPIXENT Syringe.
    • Do not put the DUPIXENT Syringe into direct sunlight.
    • Do not keep DUPIXENT Syringes at room temperature for more than 14 days. Throw away (dispose of) any DUPIXENT Syringes that have been left at room temperature for longer than 14 days.
  1. Choose your injection site
    • You can inject into your thigh or stomach, except for the 2 inches (5 cm) around your belly button (navel).
    • If a caregiver injects your dose, they can also use the outer area of the upper arm.
    • Choose a different site each time you inject DUPIXENT.
    • Do not inject into skin that is tender, damaged, bruised or scarred.
  2. Clean
    • Wash your hands.
    • Clean the injection site with an alcohol wipe.
    • Let your skin dry before injecting.
    • Do not touch the injection site again or blow on it before the injection.
  1. Remove Needle Cap
    • Hold the DUPIXENT Syringe in the middle of the Syringe Body with the Needle pointing away from you and pull off the Needle Cap.
    • Do not put the Needle Cap back on.
    • Do not touch the Needle.
    • Inject your medicine right away after removing the Needle Cap.
  2. Pinch

    Pinch a fold of skin at the injection site (thigh or stomach, except 2 inches around your belly button, or outer area of the upper arm if injected by your caregiver). The figure shows an example of pinching a fold of skin on your stomach.

  3. Insert
    • Insert the Needle completely into the fold of the skin at about a 45-degree angle.
  4. Push
    • Relax the pinch.
    • Push the Plunger Rod down slowly and steadily as far as it will go, until the DUPIXENT Syringe is empty.
    • Note: You will feel some resistance. This is normal.
  5. Release and Remove
    • Lift your thumb to release the Plunger Rod until the Needle is covered by the Needle Shield and then remove the Syringe from the injection site.
    • Lightly press a cotton ball or gauze on the injection site if you see any blood.
    • Do not put the Needle Cap back on.
    • Do not rub your skin after the injection.
  6. Dispose
    • Put your used Needles, DUPIXENT Syringes, and Needle Caps in an FDA-cleared sharps disposal container right away after use.
    • Do not dispose of (throw away) Needles, DUPIXENT Syringes, and Needle Caps in your household trash.
    • If you do not have a FDA-cleared sharps disposal container, you may use a household container that is:
      • Made of a heavy-duty plastic,
      • Can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
      • Upright and stable during use,
      • Leak-resistant, and
      • Properly labeled to warn of hazardous waste inside the container
    • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used Needles and Syringes.
    • For more information about safe sharps disposal and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal.
    • Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container.
    • Do not put the Needle Cap back on.
PRE-FILLED PEN SELF-INJECTION

Tom:

Hey, I’m Tom. Thanks for watching. Today I’m going to show you how to properly self-inject a dose of DUPIXENT (dupilumab), using the single-dose pre-filled pen.

Since you’ve already learned how to self-inject with your healthcare provider, I’ll be here to guide your through your first at-home experience.

To some, self-injections can be intimidating. I was nervous when I first started, but with some practice and help from my healthcare provider, I’ve gotten much better at the process, and I want to share those steps with you, today.

First thing we’ll go over is: What supplies to gather, How to prep the injection area, and How to inject the dose and discard your single-use, pre-filled pen.

If you haven’t yet read the instructions for use located in your DUPIXENT treatment packaging, pause the video and take a look. Please read all the instructions carefully, before using the pre-filled pen.

VO:

Let’s take a closer look at the pre-filled pen. I found it helpful to review the different parts of the pre-filled pen, like the cap, the window and the needle cover, before handling the pre-filled pen itself.

Contact your healthcare provider or the DUPIXENT MyWay Hotline with questions. They’re always there to help.

Tom:

Ok, it’s time for me to take my DUPIXENT Injection. Feel free to watch me as I self-inject.

VO:

To begin, take your medication out of the refrigerator.

  • Keep the pre-filled pen and all medicines out of the reach of children
  • Keep unused pre-filled pens in the original carton and store in the refrigerator between or 35° - 46° F [2°-8°C]

Take one pen out of the packaging by holding the middle of the pen body.

Now, let’s check the label on the pen to ensure that the medication and dosage strength are correct and the expiration date has not passed.

Do not use the pen if the expiration date has passed. If the dosage strength or expiration date isn’t right, contact your pharmacy.

Next, take a look at the medicine through the viewing window. The liquid inside should be clear and colorless, to pale yellow. You may see an air bubble. This is totally normal.

  • Do not inject DUPIXENT if the liquid inside is discolored or cloudy, or contains visible flakes or particles .
  • Do not use the pre-filled pen if the window is solid yellow.
  • Do not use the pre-filled pen if it has been damaged.
  • Do not use the pre-filled pen if the cap is missing or not securely attached .

If you have any questions about whether the pen is okay to use, please call the DUPIXENT MyWay Hotline or your healthcare provider.

If you have an unused pre-filled pen, return it to the refrigerator in the original carton to protect it from light.

Lay the pre-filled pen on a flat surface and let it naturally warm to room temperature.

  • Do not store DUPIXENT pre-filled pens at room temperatures more than 77°F (25°C)

The recommended warming time for the 300mg pen is 45 minutes.

  • Do not freeze or heat the pre-filled pen
  • Do not put the pre-filled pen into direct sunlight
  • Do not keep DUPIXENT at room temperature, 77°F (25°C), for more than 14 days
  • Throw away any used pre-filled pen that has been left at room temperature for more than 14 days
  • Do not shake the pre-filled pen at any time

As the pen warms up, let’s gather some additional materials you’ll need to self-inject. You’ll need a cotton ball or gauze, an alcohol wipe, and a puncture resistant Sharps Disposal Container.

If you don’t have a Sharps disposal container, call a DUPIXENT MyWay representative to request a complimentary Sharps disposal Container.

If you don’t have a puncture resistant disposal container, call your pharmacy, healthcare provider, or DUPIXENT patient support to request a puncture resistant disposal container.

We’re almost ready to inject DUPIXENT.

First, let’s wash our hands thoroughly with soap and water.

Now, take your supplies to an area where you can sit comfortably. I prefer the comfort of my living room couch, you might prefer the bathroom, or your bedroom for privacy.

Next, let’s choose an injection site. Both the stomach and thigh are acceptable, except for the 5 cm [OR 2 in] around your belly button.

If a caregiver gives you the injection, the outer area of the upper arm is also an option. The person giving the injection should follow the same preparation procedure.

Be sure to choose a different site each time you inject DUPIXENT.

  • Do not inject through clothes
  • Do not inject into skin that is tender, damaged, bruised or scarred, or into areas with visible veins.

Now, clean your skin with the alcohol wipe.

Do not touch the injection site again or blow on it before the injection.

Let your skin dry before injection.

Pick up the pen by holding the middle of the pen body with the needle pointing away from you. With your other hand, pull the cap straight off. Once you have removed the cap, do not put it back on.

  • Do not twist the cap off
  • Do not remove the cap until you are ready to inject
  • Do not press or touch the needle cover with your fingers
  • Do not try to put the cap back on once you’ve removed it

Place the needle cover on your skin at approximately a 90-degree angle. Make sure you can see the injector window.

Press down and hold the pen firmly against your skin until you can no longer see the needle cover. There will be a “click” when the injection starts.

As you hold the pen firmly against your skin, the injector window will start to turn yellow. The injection can take up to 20 seconds.

  • Be sure to watch the window turn fully yellow.

You may hear a second “click”. Check to see if the entire window has turned yellow before removing the pen. Slowly count to 5 and then lift the pen straight up off the skin.

  • Keep the pen pressed against. Your skin as you count to 5 to ensure you are getting a full dose of DUPIXENT.

That’s it!

If the window does not turn fully yellow, remove the pen and call your healthcare provider. Do not give yourself a second dose without speaking to your healthcare provider.

Lightly press a cotton ball or gauze on the injection site if you see any blood. You can also cover the site with a bandage. If the bleeding doesn’t stop, contact your healthcare provider.

  • Do not rub your skin after the injection.

Be sure to put the used pen and its cap into a puncture-resistant Sharps Disposal Container right away after use.

  • Your puncture resistant disposal container may look different than the one shown here.
  • Do not re-use the pre-filled pen
  • Do not throw away the used pen in your household waste
  • Do not recycle your used puncture-resistant container
  • Keep your Sharps disposal container out of the reach of children

Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once it is full.

Be sure to keep track of your injection date and site.

Tom:

Thank you for joining me today. Remember, you can re-watch this video as often as you like to refresh your memory.

Contact your healthcare provider or the DUPIXENT MyWay Hotline with any questions or concerns.

PRE-FILLED PEN CAREGIVER INJECTION

To Camera:

Mom: Hi there. Thanks for watching. Today we’re going to show you how to properly inject a dose DUPIXENT (dupilumab), using the single-dose pre-filled pen. Since you’ve already learned how to self-inject with your healthcare provider, we’re here to guide your through your first at-home experience. When I first started giving injections, I found it intimidating, but with a little practice and help from our healthcare provider, I’ve gotten much better at the process, and I want to share these steps with you, today.

First thing we’ll go over is: What supplies to gather, How to prep the injection area, and How to inject the dose and discard your single-dose pre-filled pen. If you haven’t yet read the instructions for use located in your DUPIXENT treatment package, pause the video and take a look. Please read all the instructions carefully, before using the pre-filled pen.

VO:Let’s take a closer look at the pre-filled pen. I found it helpful to review the different parts of the pre-filled pen, like the cap, the window and the needle cover, before handling the pre-filled pen itself. 

Contact your healthcare provider or the DUPIXENT MyWay Hotline with questions. They’re always there to help.

To Camera:

Mom:Ok, it’s time for your DUPIXENT injection. Are you ready?

Daughter: Yeah.

VO: To begin, take your medication out of the refrigerator.

  • [SUPER] Keep the pre-filled pen and all medicines out of the reach of children
  • [SUPER] Keep unused pre-filled pens in the original carton and store in the refrigerator between 36° - 46° F [or 2°-8°C]

Take one pen out of the packaging by holding the middle of the pen body. Now, let’s check the label on the pen to ensure that the medication and dosage strengths are correct and the expiration date has not passed. Do not use the pen if the expiration date has passed. If the dosage strength or expiration date isn’t right, contact your pharmacy. Next, take a look at the medicine through the viewing window. The liquid inside should be clear and colorless, to pale yellow. You may see an air bubble. This is totally normal.

  • [SUPER] Do not inject DUPIXENT if the liquid inside is discolored or cloudy, or contains visible flakes or particles
  • [SUPER] Do not use the pre-filled pen if the window is solid yellow
  • [SUPER] Do not use the pre-filled pen if it has been damaged
  • [SUPER] Do not use the pre-filled pen if the cap is missing or not securely attached

If you have any questions about whether the pen is okay to use, please call the DUPIXENT MyWay Hotline or your healthcare provider. If you have an unused pre-filled pen, return it to the refrigerator in the original carton to protect it from light.

Lay the pre-filled pen on a flat surface and let it naturally warm to a room temperature of less than 77°F.

  • [SUPER] Do not store DUPIXENT pre-filled pens at room temperatures more than 77°F (25°C)

The recommended warming time for the 300mg pen is 45 minutes.

    [SUPER] Do not freeze or heat the pre-filled pen
  • [SUPER] Do not put the pre-filled pen into direct sunlight
  • [SUPER] Do not keep DUPIXENT at room temperature, less than or equal to 77°F (25°C), for more than 14 days
  • [SUPER] After removing a DUPIXENT Pre-filled Pen from the refrigerator, it must be used within 14 days or thrown away (disposed of)

Throw away any used pre-filled pen that has been left at room temperature for more than 14 days.

  • [SUPER] Do not shake the pre-filled pen at any time

As the pen warms up, let’s gather some additional materials you’ll need to inject. You’ll need a cotton ball or gauze, an alcohol wipe, and a puncture resistant sharps disposal container.

  • [SUPER] Your puncture resistant disposal container may look different than the one shown here.

If you don’t have a sharps disposal container, call a DUPIXENT MyWay representative to request a complimentary sharps disposal container.

We’re almost ready to inject DUPIXENT.

First, let’s wash our hands thoroughly with soap and water.

Now, take your supplies to an area where you can sit comfortably. I prefer the comfort of our living room couch, you might prefer the bathroom, or your bedroom for privacy.

Next, let’s choose an injection site. Both the stomach and thigh are acceptable, except for the 5 cm [OR 2 in] around your belly button.

The outer area of the upper arm is also an option since you are giving the injection to someone, but not if you are self-injecting.

Be sure to choose a different site each time you inject DUPIXENT.

  • [SUPER] Do not inject through clothes.
  • [SUPER] Do not inject into skin that is tender, damaged, bruised or scarred, or into areas with visible veins.

Now, clean the skin with the alcohol wipe.

Do not touch the injection site again or blow on it before the injection. Let your skin dry before injection.

Pick up the pen by holding the middle of the pen body with the needle pointing away from you. With your other hand, pull the cap straight off.

Once you have removed the cap, do not put it back on.

  • [SUPER] Do not twist the cap off
  • [SUPER] Do not remove the cap until you are ready to inject
  • [SUPER] Do not press or touch the needle cover with your fingers, the needle is inside
  • [SUPER] Do not try to put the cap back on once you’ve removed it

Place the needle cover on the skin at approximately a 90-degree angle. Make sure you can see the injector window.

Press down and hold the pen firmly against the skin until you can no longer see the needle cover. There will be a “click” when the injection starts.

As you hold the pen firmly against the skin, the injector window will start to turn yellow. The injection can take up to 20 seconds.

  • [SUPER] Be sure to watch the window turn fully yellow.
  • You will hear a second “click”. Check to see if the entire window has turned yellow. Keep the pen pressed against your skin as you count to 5 to ensure you are getting a full dose of DUPIXENT and lift the pen straight up off the skin.
  • [SUPER] Keep the pen pressed against your skin as you count to 5 to ensure you are getting a full dose of DUPIXENT.

That’s it!

If the window does not turn fully yellow, remove the pen and call your healthcare provider. Do not give a second dose without speaking to your healthcare provider.

Lightly press a cotton ball or gauze on the injection site if you see any blood. You can also cover the site with a bandage. If the bleeding doesn’t stop, contact your healthcare provider.

  • [SUPER] Do not rub your skin after the injection.

Be sure to put the used pen and its cap into a puncture-resistant sharps disposal container right away after use.

  • [SUPER] Your puncture resistant disposal container may look different than the one shown here.
  • [SUPER] Do not re-use the pre-filled pen
  • [SUPER] Do not dispose of pre-filled pens in your household trash
  • [SUPER] Do not recycle your used puncture-resistant container
  • [SUPER] Keep your sharps disposal container out of the reach of children

Follow your local guidelines and ask your pharmacy or healthcare provider for the appropriate way to dispose of your used pen.

Be sure to keep track of your injection date and site.

To Camera:

Thank you for joining us today.

Remember, you can re-watch this video as often as you like to refresh your memory.

Contact your healthcare provider or the DUPIXENT MyWay Hotline with questions.

PRE-FILLED PEN INSTRUCTIONS

  1. Gather Supplies

    Find a clean, flat work surface. Make sure you have the following supplies:

    • DUPIXENT Pre-filled Pen
    • 1 alcohol wipe*
    • 1 cotton ball or gauze*
    • Sharps Disposal Container* (See Step 14)

    * Items not included in the carton

  2. Check the Pen
    • Do not use the DUPIXENT Pre-filled Pen if it has been damaged.
    • Do not use the DUPIXENT Pre-filled Pen if the Green Cap is missing or not securely attached.
    • Do not use the DUPIXENT Pre-filled Pen if the Window is yellow before use.
  3. Look at the Label
    • Check to be sure that you have the correct Medicine and dose.
    • Check the expiration date.
      • Do not use the DUPIXENT Pre-filled Pen if the expiration date has passed.
  4. Check the Medicine
    • Look at the Medicine through the Window on the DUPIXENT Pen: Check if the liquid is clear and colorless to pale yellow.
    • Note: You may see an air bubble, this is normal.
    • Do not use the DUPIXENT Pre-filled Pen if the liquid is discolored or cloudy, or if it contains visible flakes or particles.
  5. Wait 45 minutes

    Lay the DUPIXENT Pre-filled Pen on a flat surface and let it naturally warm up at room temperature less than 77°F (25°C) for at least 45 minutes.

    • Do not heat the DUPIXENT Pre-filled Pen in a microwave, hot water or direct sunlight.
  1. Wash your hands well with soap and water
  2. Choose an injection site
    • Thigh
    • Stomach except for the 2 inches (5 cm) are your belly button (navel).
    • Upper arm if a caregiver gives your dose, they can also use the outer area of the upper arm.
    • Choose a different injection site for each DUPIXENT injection.
    • Do not inject into skin that is tender, damaged, has bruises or scars, or into areas with visible veins.
    • Do not inject through clothes.
  3. Prepare the injection site
    • Clean the injection site with an alcohol wipe.
    • Let your skin dry before injecting.
    • Do not touch the injection site again or blow on it before the injection.
  1. Remove Green Cap
    • Remove the Green Cap by pulling it straight off, as shown. Do not twist the Green Cap off.
    • Do not remove the Green Cap until you are ready to inject.
    • Do not press or touch the Yellow Needle Cover with your fingers. The Needle is inside.
    • Do not put the Green Cap back on the DUPIXENT Pre-filled Pen after you have removed it.
  2. Place
    • Hold the DUPIXENT Pre-filled Pen as shown so that you can see the Window. Place the Yellow Needle Cover on your skin.
    • Place the Yellow Needle Cover on your skin at approximately a 90-degree angle.
  3. Press Down, Watch Window turn fully yellow, then count to 5
    • Press and hold the DUPIXENT Pre-filled Pen firmly against your skin until you cannot see the Yellow Needle Cover.
      • There will be a “click” when the injection starts, and
      • The Window will start to turn yellow.
      • Keep pressing the DUPIXENT Pre-filled Pen against your skin.
    • Keep pressing the DUPIXENT Pre-filled Pen against your skin and watch the window:
      • The window will turn completely yellow, and
      • You will hear a 2nd “click”.
      • Keep pressing the DUPIXENT Pre-filled Pen against your skin.
    • Keep pressing the DUPIXENT Pre-filled Pen against your skin and count to 5 to make sure you get your full dose.
  4. Remove
    • After you have completed your injection pull straight up to remove DUPIXENT Pre-filled Pen from the skin. The Yellow Needle Cover will cover the needle.
    • If you see any blood at the site, lightly dab a cotton ball or gauze pad.
      • Do not rub your skin after the injection.
    • If the Window does not turn completely Yellow, remove the pen and call your healthcare provider.
      • Do not give yourself a second dose without speaking with your healthcare provider.
  1. How to Dispose of (throw away) DUPIXENT Pre-filled Pen
    • Put your used DUPIXENT Pre-filled Pens, and Green Caps in a FDA-cleared sharps disposal container right away after use.
    • Do not dispose of (throw away) DUPIXENT Pre-filled Pens and Green Caps in your household trash.
    • If you do not have a FDA-cleared sharps disposal container, you may use a household container that is:
      • Made of a heavy-duty plastic,
      • Can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
      • Upright and stable during use,
      • Leak-resistant, and
      • Properly labeled to warn of hazardous waste inside the container
    • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used DUPIXENT Pre-filled Pens. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal
    • Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this.
    • Do not recycle your used sharps disposal container.
    • Keep your sharps disposal container out of reach of children.

    This Instructions for Use has been approved by the U.S. Food and Drug Administration.

PUT YOURSELF IN THE RIGHT
FRAME OF MIND

Your healthcare provider has shown you how to administer DUPIXENT and provided additional guidance, such as the need to select a different injection site each time. But are you or your loved one still feeling nervous about injecting?

One way to help reduce nervousness is to simply take time to breathe.

When you’re mindful of the present moment, you allow yourself time to accept your feelings, which may help you to manage those nerves.

FOLLOW THESE INJECTION
BEST PRACTICES

  • Choose a different site each time you inject DUPIXENT
  • Do not inject into skin that is tender, damaged, or bruised, or scarred
  • Always clean your skin with the alcohol wipe
  • Do not touch the injection site again or blow on it before the injection. Let your skin dry before injection
  • Do not rub your skin after the injection

*Please always consult the Instructions for Use for more information

NURSE EDUCATORS CAN OFFER VIRTUAL SUPPLEMENTAL TRAINING

DUPIXENT MyWay Nurse Educators are trained to help provide patients with supplemental injection training online, over the phone, or in person with a training kit and practice syringe or practice pen.

For more information, dial
1‑844‑DUPIXENT (1-844-387-4936), option 1
Monday-Friday, 8 am - 9 pm EST

STAY ON TRACK WITH DUPIXENT

Hear from patients about starting DUPIXENT and staying on a consistent treatment schedule,
sign up for injection reminders, and find ideas for staying on treatment while you are traveling.

get more information