INJECTION
SUPPORT CENTER

MOM: Since you’re watching this video, I know you’ve already learned how to give an injection with your healthcare provider. I’m just here to help guide you through your first at-home experience.

When I first started giving injections, I found syringes really intimidating. I've gotten better at the process since then, so I wanted to share those steps with you today.

If you haven’t yet read the Instructions for Use located in your treatment packaging, pause the video and take a look. And if you have any questions along the way, don’t hesitate to reach out to your healthcare provider or the DUPIXENT MyWay hotline. They’re always there to help.

MOM: Are you ready? ...Okay. Are you ready?

SON: What?

MOM: Let’s show them how to properly inject a dose of DUPIXENT.

SON: Oh, sure.

MOM: First, take your medication out of the refrigerator. Never freeze your syringe.

Remove the syringe by holding the middle of the syringe body.

A few things to remember:

• Do not use the syringe if it has been dropped on a hard surface or is damaged.
• Do not pull off the needle cap or touch the plunger rod until you are ready to inject.
• Do not pull back on the plunger rod at any time.
• Keep DUPIXENT syringes and all medicines out of the reach of children.

If you have an unused syringe, return it to the refrigerator in the original carton to protect it from light.

Your DUPIXENT pre-filled syringe may appear different from what you see in this video, based on the prescribed dose. If you have questions about the dosage prescribed, please contact your healthcare provider.

OK, now it’s time to check the label to make sure the medication and dosage are correct and the expiration date has not passed. If it isn’t right, contact your pharmacy.

SON: Looks right to me.

MOM: Yup.

Now look at the medicine through the Viewing Window on the DUPIXENT syringe. The liquid inside should be clear and colorless to pale yellow. You may see an air bubble; this is normal. Do not try to get rid of any air bubbles.

Do not use the syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles. Throw away and dispose of, the used DUPIXENT single-dose, pre-filled syringe right away after use.

If you have any questions about whether the syringe is OK to use, please call the DUPIXENT MyWay hotline, or your healthcare provider.

Lay the syringe on a flat surface and let it naturally warm to room temperature.

The recommended warming time for the 100mg syringe is 30 minutes. The 200mg syringe is also 30 minutes, and the 300mg syringe is 45 minutes.

Here are a few more things to remember:

• Do not heat the syringe.
• Do not put the syringe into direct sunlight.
• Do not keep DUPIXENT at room temperature for more than 14 days. Throw away any syringe that has been left at room temperature for longer than 14 days.
• Do not shake the syringe.

While you wait, gather the additional necessary materials.

You need one cotton ball or gauze.

SON: Check.

MOM: One alcohol wipe.

SON: Check.

MOM: And a puncture-resistant sharps disposal container.

SON: Check.

MOM: If you don’t have a sharps disposal container, call a DUPIXENT MyWay representative to request a complimentary Sharps Disposal Container.

When you are ready to get started, wash your hands thoroughly.

Now, take your supplies to an area where you can sit comfortably.

Choose your injection site. Both the stomach and thigh are acceptable, except for the two inches around the belly button. The outer area of the upper arm is also an option since you are giving the injection to someone, but not if you’re self-injecting.

Be sure to choose a different site each time you inject DUPIXENT.

• Do not inject through clothes.
• Do not inject into skin that is tender, damaged, bruised, or scarred.

OK, now clean the skin with the alcohol wipe.

Do not touch the injection site again or blow on it before the injection.

Once the skin is dry, hold the DUPIXENT syringe in the middle of the syringe body with the needle pointing away from you and carefully remove the cap from the syringe.

• Do not use if the needle cap is missing or not securely attached.
• Do not put the needle cap back on.
• Do not touch the needle. Inject the medicine right away after removing the needle cap.

Pinch a fold of skin at the injection site. Pinching the skin helps the medicine go into a fatty layer, just below the skin, and not into the muscle.

Take a deep breath.

Continue to pinch as you insert the needle completely at about a 45° angle.

Relax your pinch.

Push the plunger down slowly and steadily as far as it will go, until the syringe is empty. You will feel some resistance. This is normal.

Lift your thumb to release the plunger rod until the needle is covered by the needle shield and then remove the syringe from the injection site.

Lightly press a cotton ball or gauze on the injection site if you see any blood. Do not put the needle cap back on, and do not rub the skin after the injection.

SON: Got it.

MOM: You can also cover the site with a bandage.

OK, now put the used DUPIXENT syringe and cap in an FDA-cleared Sharps Disposal Container right away after use.

Do not put DUPIXENT syringes in your household trash. Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once it is full.

Do not recycle your used sharps disposal container. And do not reuse the syringe.

If you would like to practice before doing the actual injection and you have received the DUPIXENT training kit from your doctor's office, you can practice the 45° injection angle with the training syringe and the angle aid. Do not use the angle aid to administer an actual injection.

Finally, always be sure to keep track of the injection date and site.

Well, now you know how to give a dose of DUPIXENT. If you follow these steps, you’ll be a pro in no time.

Feel free to rewatch this video as many times as you’d like. And again, reach out to your healthcare provider or call the DUPIXENT MyWay hotline if you have any questions.

Well, that wasn’t so bad, was it?

SON: What?

To Camera

Hey, I’m Tom. Thanks for watching. Today I’m going to show you how to properly self-inject a dose of DUPIXENT (dupilumab), using the single-dose pre-filled pen.

Since you’ve already learned how to self-inject with your healthcare provider, I’ll be here to guide you through your first at-home experience.

To some, self-injections can be intimidating. I was nervous when I first started, but with some practice and help from my healthcare provider, I’ve gotten much better at the process, and I want to share those steps with you, today.

First thing we’ll go over is: what supplies to gather, how to prep the injection area, and how to inject the dose and discard your single-dose, pre-filled pen.

If you haven’t yet read the instructions for use located in your DUPIXENT treatment packaging, pause the video and take a look. Please read all the instructions carefully, before using the pre-filled pen.

Voiceover

The steps for treating yourself with the DUPIXENT single-dose pre-filled pen are the same for the 200mg and 300mg dosage strengths, except for the warming time, which will be described in more detail later. In this video I’ll show you how to use the 300mg pen, so if you’ve been prescribed the 200mg pen, the device will appear different than what you see in this video. If you have any questions about the dosage prescribed, please contact your healthcare provider.

• Your device may appear different than what you see in this video, based on your prescribed dose.

Let’s take a closer look at the pre-filled pen. I found it helpful to review the different parts of the pre-filled pen, like the cap, the window and the needle cover, before handling the pre-filled pen itself.

Contact your healthcare provider or the DUPIXENT MyWay Hotline with questions. They’re always there to help.

To Camera

Ok, it’s time for me to take my DUPIXENT injection. Feel free to watch me as I self-inject.

Voiceover

To begin, take your medication out of the refrigerator.

• Keep the pre-filled pen and all medicines out of the reach of children
• Keep unused pre-filled pens in the original carton and store in the refrigerator between 36° - 46° F [2°-8°C]

Next, remove the DUPIXENT "Instructions For Use" from the packaging and read it completely before using the pre-filled pen.

Take one pen out of the packaging by holding the middle of the pen body.

Now, let’s check the label on the pen to ensure that the medication and dosage strength are correct and the expiration date has not passed.

Next, take a look at the medicine through the viewing window. The liquid inside should be clear and colorless, to pale yellow. You may see an air bubble. This is totally normal.

• Do not inject DUPIXENT if the liquid inside is discolored or cloudy, or contains visible flakes or particles.
• Do not use the pre-filled pen if the window is solid yellow.
• Do not use the pre-filled pen if it has been damaged.
• Do not use the pre-filled pen if the cap is missing or not securely attached.

If you have any questions about whether the pen is okay to use, please call the DUPIXENT MyWay Hotline or your healthcare provider.

If you have an unused pre-filled pen, return it to the refrigerator in the original carton to protect it from light.

Lay the pre-filled pen on a flat surface and let it naturally warm at a room temperature.

• Do not store DUPIXENT pre-filled pens at room temperatures more than 77°F (25°C)

The recommended warming time for the 200mg pen is 30 minutes, and for the 300mg pen, it's 45 minutes.

• Do not freeze or heat the pre-filled pen
• Do not put the pre-filled pen into direct sunlight
• Do not keep DUPIXENT at room temperature, 77°F (25°C), for more than 14 days
• After removing a DUPIXENT pre-filled pen from the refrigerator, it must be used within 14 days or thrown away (disposed of)
• Do not shake the pre-filled pen at any time

As the pen warms up, let’s gather some additional materials you’ll need to self-inject. You’ll need a cotton ball or gauze, an alcohol wipe, and a puncture resistant Sharps Disposal Container.

If you don’t have a Sharps disposal container, call a DUPIXENT MyWay representative to request a complimentary Sharps Disposal Container.

• Your puncture resistant disposal container may look different than the one shown here

We’re almost ready to inject DUPIXENT. First, let’s wash our hands thoroughly with soap and water.

Now, take your supplies to an area where you can sit comfortably. I prefer the comfort of my living room couch, you might prefer the bathroom, or your bedroom for privacy.

Next, let’s choose an injection site. Both the stomach and thigh are acceptable, except for the “5 centimeters or 2 inches” around your belly button.

If a caregiver gives you the injection, the outer area of the upper arm is also an option. The person giving the injection should follow the same preparation procedure.

Be sure to choose a different site each time you inject DUPIXENT.

• Do not inject through clothes
• Do not inject into skin that is tender, damaged, bruised or scarred, or into areas with visible veins.

Now, clean your skin with the alcohol wipe. Do not touch the injection site again or blow on it before the injection. Let your skin dry before injection.

Pick up the pen by holding the middle of the pen body with the needle pointing away from you. With your other hand, pull the cap straight off. Once you have removed the cap, do not put it back on.

• Do not twist the cap off
• Do not remove the cap until you are ready to inject
• Do not press or touch the needle cover with your fingers
• Do not try to put the cap back on once you’ve removed it

Place the needle cover on your skin at approximately a 90-degree angle. Make sure you can see the injector window.

Press down and hold the pen firmly against your skin until you can no longer see the needle cover.

There will be a “click” when the injection starts.

As you hold the pen firmly against your skin, the injector window will start to turn yellow.

The injection can take up to 20 seconds.

Be sure to watch the window turn completely yellow.

You may hear a second "click".

Check to see if the entire window has turned yellow.

Keep the pen pressed against your skin as you count to five to ensure you are getting a full dose of DUPIXENT and then lift the pen straight up off the skin.

• Keep the pen pressed against your skin as you count to five to ensure you are getting a full dose of DUPIXENT

That’s it!

If the Window does not turn completely Yellow, or if it looks like medicine is still coming out of the pen, you may not have received a full dose. Throw away (dispose of) the pen and contact your healthcare provider right away. Do not give yourself a second dose without speaking to your healthcare provider.

Lightly press a cotton ball or gauze on the injection site if you see any blood. You can also cover the site with a bandage. If the bleeding doesn’t stop, contact your healthcare provider.

• Do not rub your skin after the injection.

Be sure to put the used pen and its cap into a puncture-resistant Sharps Disposal Container right away after use.

• our puncture resistant disposal container may look different than the one shown here
• Do not re-use the pre-filled pen
• Do not throw away the used pen in your household waste
• Do not recycle your used puncture-resistant container
• Keep your Sharps disposal container out of the reach of children

Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once it is full.

Be sure to keep track of your injection date and site.

To Camera

Thank you for joining me today. Remember, you can rewatch this video as often as you like to refresh your memory.

Contact your healthcare provider or the DUPIXENT MyWay Hotline with questions.

ISI Voiceover

To Camera

Mom: Hi there. Thanks for watching. Today we’re going to show you how to properly inject a dose of DUPIXENT (dupilumab), using the single-dose pre-filled pen.

Since you’ve already learned how to self-inject with your healthcare provider, we’re here to guide you through your first at-home experience.

When I first started giving injections, I found it intimidating, but with a little practice and help from our healthcare provider, I’ve gotten much better at the process, and I want to share these steps with you, today.

First thing we’ll go over is: What supplies to gather, How to prep the injection area, and How to inject the dose and discard your single-dose pre-filled pen.

If you haven’t yet read the instructions for use located in your DUPIXENT treatment package, pause the video and take a look. Please read all the instructions carefully, before using the pre-filled pen.

Voiceover

MOM:The steps for using the DUPIXENT single-dose pre-filled pen are the same for the 200mg and 300mg dosage strengths, except for the warming time, which will be described in more detail later. In this video we’ll show you how to use the 300mg pen, so if you’ve been prescribed the 200mg pen, the device will appear different than what you see in this video. If you have any questions about the dosage prescribed, please contact your healthcare provider.

• Your device may appear different than what you see in this video, based on your prescribed dose.

Let’s take a closer look at the pre-filled pen. I found it helpful to review the different parts of the pre-filled pen, like the cap, the window and the needle cover, before handling the pre-filled pen itself. 

Contact your healthcare provider or the DUPIXENT MyWay Hotline with questions. They’re always there to help.

To Camera

Mom: Ok, it’s time for your DUPIXENT injection. Are you ready?

Daughter: Yeah.

Mom: Feel free to watch us, as I give an injection.

Voiceover

MOM: To begin, take your medication out of the refrigerator.

• Keep the pre-filled pen and all medicines out of the reach of children
• Keep unused pre-filled pens in the original carton and store in the refrigerator between 36° - 46° F [or 2°-8°C]

Next, remove the DUPIXENT “Instructions For Use” from the packaging and read it completely before using the pre-filled pen.

Take one pen out of the packaging by holding the middle of the pen body.

Now, let’s check the label on the pen to ensure that the medication and dosage strengths are correct and the expiration date has not passed. Do not use the pen if the expiration date has passed. If the dosage strength or expiration date isn’t right, contact your pharmacy.

Next, take a look at the medicine through the viewing window. The liquid inside should be clear and colorless, to pale yellow. You may see an air bubble. This is totally normal.

• Do not inject DUPIXENT if the liquid inside is discolored or cloudy, or contains visible flakes or particles
• Do not use the pre-filled pen if the window is solid yellow
• Do not use the pre-filled pen if it has been damaged
• Do not use the pre-filled pen if the cap is missing or not securely attached

If you have any questions about whether the pen is okay to use, please call the DUPIXENT MyWay Hotline or your healthcare provider. If you have an unused pre-filled pen, return it to the refrigerator in the original carton to protect it from light.

If you have an unused pre-filled pen, return it to the refrigerator in the original carton to protect it from light.

Lay the pre-filled pen on a flat surface and let it naturally warm to a room temperature of less than 77°F.

• Do not store DUPIXENT pre-filled pens at room temperatures more than 77°F (25°C)

The recommended warming time for the 200mg pen is 30 minutes, and for the 300mg pen, it's 45 minutes.

• Do not freeze or heat the pre-filled pen
• Do not put the pre-filled pen into direct sunlight
• Do not keep DUPIXENT at room temperature less than or equal to 77°F (25°C), for more than 14 days
• After removing a DUPIXENT Pre-filled Pen from the refrigerator, it must be used within 14 days or thrown away (disposed of)
• Throw away any used pre-filled pen that has been left at room temperature for more than 14 days.
• Do not shake the pre-filled pen at any time

As the pen warms up, let’s gather some additional materials you’ll need to inject.

You’ll need a cotton ball or gauze, an alcohol wipe, and a puncture resistant sharps disposal container.

If you don’t have a sharps disposal container, call a DUPIXENT MyWay representative to request a complimentary sharps disposal container.

• Your puncture resistant disposal container may look different than the one shown here.

We’re almost ready to inject DUPIXENT. First, let’s wash our hands thoroughly with soap and water.

Now, take your supplies to an area where you can sit comfortably. I prefer the comfort of our living room couch, you might prefer the bathroom, or your bedroom for privacy.

Next, let’s choose an injection site. Both the stomach and thigh are acceptable, except for the 5 centimeters or 2 inches around your belly button.

The outer area of the upper arm is also an option since you are giving the injection to someone, but not if you are self-injecting.

Be sure to choose a different site each time you inject DUPIXENT.

• Do not inject through clothes.
• Do not inject into skin that is tender, damaged, bruised or scarred, or into areas with visible veins.

Now, clean the skin with the alcohol wipe. Do not touch the injection site again or blow on it before the injection. Let your skin dry before injection.

Pick up the pen by holding the middle of the pen body with the needle pointing away from you. With your other hand, pull the cap straight off.

Once you have removed the cap, do not put it back on.

• Do not twist the cap off
• Do not remove the cap until you are ready to inject
• Do not press or touch the needle cover with your fingers; the needle is inside
• Do not try to put the cap back on once you’ve removed it

Place the needle cover on the skin at approximately a 90-degree angle. Make sure you can see the injector window.

Press down and hold the pen firmly against the skin until you can no longer see the needle cover. There will be a “click” when the injection starts.

As you hold the pen firmly against the skin, the injector window will start to turn yellow.

The injection can take up to 20 seconds.

Be sure to watch the window turn fully yellow.

You will hear a second “click”. Check to see if the entire window has turned yellow. Keep the pen pressed against your skin as you count to 5 to ensure you are getting a full dose of DUPIXENT and lift the pen straight up off the skin.

• Keep the pen pressed against your skin as you count to 5 to ensure you are getting a full dose of DUPIXENT.

That’s it!

If the Window does not turn completely Yellow, or if it looks like medicine is still coming out of the pen, you may not have received a full dose. Dispose of (throw away) the pen and contact your healthcare provider right away. Do not give yourself a second dose without speaking to your healthcare provider.

Lightly press a cotton ball or gauze on the injection site if you see any blood. You can also cover the site with a bandage. If the bleeding doesn't stop, contact your healthcare provider.

• Do not rub your skin after the injection.

Be sure to put the used pen and its cap into a puncture-resistant sharps disposal container right away after use.

• Your puncture resistant disposal container may look different than the one shown here
• Do not re-use the pre-filled pen
• Do not dispose of pre-filled pens in your household trash
• Do not recycle your used puncture-resistant container
• Keep your sharps disposal container out of the reach of children

Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once its full.

Be sure to keep track of your injection date and site.

To Camera

MOM:Thank you for joining us today. Remember, you can re-watch this video as often as you like to refresh your memory. Contact your healthcare provider or the DUPIXENT MyWay Hotline with questions.

ISI Voiceover