INJECTION SUPPORT
CENTER

To Camera:

Mom: Hi there. Thanks for watching. Today we’re going to show you how to properly inject a dose DUPIXENT (dupilumab), using the single-dose pre-filled pen. Since you’ve already learned how to self-inject with your healthcare provider, we’re here to guide your through your first at-home experience. When I first started giving injections, I found it intimidating, but with a little practice and help from our healthcare provider, I’ve gotten much better at the process, and I want to share these steps with you, today.

First thing we’ll go over is: What supplies to gather, How to prep the injection area, and How to inject the dose and discard your single-dose pre-filled pen. If you haven’t yet read the instructions for use located in your DUPIXENT treatment package, pause the video and take a look. Please read all the instructions carefully, before using the pre-filled pen.

VO:Let’s take a closer look at the pre-filled pen. I found it helpful to review the different parts of the pre-filled pen, like the cap, the window and the needle cover, before handling the pre-filled pen itself. 

Contact your healthcare provider or the DUPIXENT MyWay Hotline with questions. They’re always there to help.

To Camera:

Mom:Ok, it’s time for your DUPIXENT injection. Are you ready?

Daughter: Yeah.

VO: To begin, take your medication out of the refrigerator.

• [SUPER] Keep the pre-filled pen and all medicines out of the reach of children
• [SUPER] Keep unused pre-filled pens in the original carton and store in the refrigerator between 36° - 46° F [or 2°-8°C]

Take one pen out of the packaging by holding the middle of the pen body. Now, let’s check the label on the pen to ensure that the medication and dosage strengths are correct and the expiration date has not passed. Do not use the pen if the expiration date has passed. If the dosage strength or expiration date isn’t right, contact your pharmacy. Next, take a look at the medicine through the viewing window. The liquid inside should be clear and colorless, to pale yellow. You may see an air bubble. This is totally normal.

• [SUPER] Do not inject DUPIXENT if the liquid inside is discolored or cloudy, or contains visible flakes or particles
• [SUPER] Do not use the pre-filled pen if the window is solid yellow
• [SUPER] Do not use the pre-filled pen if it has been damaged
• [SUPER] Do not use the pre-filled pen if the cap is missing or not securely attached

If you have any questions about whether the pen is okay to use, please call the DUPIXENT MyWay Hotline or your healthcare provider. If you have an unused pre-filled pen, return it to the refrigerator in the original carton to protect it from light.

Lay the pre-filled pen on a flat surface and let it naturally warm to a room temperature of less than 77°F.

• [SUPER] Do not store DUPIXENT pre-filled pens at room temperatures more than 77°F (25°C)

The recommended warming time for the 300mg pen is 45 minutes.

[SUPER] Do not freeze or heat the pre-filled pen
• [SUPER] Do not put the pre-filled pen into direct sunlight
• [SUPER] Do not keep DUPIXENT at room temperature, less than or equal to 77°F (25°C), for more than 14 days
• [SUPER] After removing a DUPIXENT Pre-filled Pen from the refrigerator, it must be used within 14 days or thrown away (disposed of)

Throw away any used pre-filled pen that has been left at room temperature for more than 14 days.

• [SUPER] Do not shake the pre-filled pen at any time

As the pen warms up, let’s gather some additional materials you’ll need to inject. You’ll need a cotton ball or gauze, an alcohol wipe, and a puncture resistant sharps disposal container.

• [SUPER] Your puncture resistant disposal container may look different than the one shown here.

If you don’t have a sharps disposal container, call a DUPIXENT MyWay representative to request a complimentary sharps disposal container.

We’re almost ready to inject DUPIXENT.

First, let’s wash our hands thoroughly with soap and water.

Now, take your supplies to an area where you can sit comfortably. I prefer the comfort of our living room couch, you might prefer the bathroom, or your bedroom for privacy.

Next, let’s choose an injection site. Both the stomach and thigh are acceptable, except for the 5 cm [OR 2 in] around your belly button.

The outer area of the upper arm is also an option since you are giving the injection to someone, but not if you are self-injecting.

Be sure to choose a different site each time you inject DUPIXENT.

• [SUPER] Do not inject through clothes.
• [SUPER] Do not inject into skin that is tender, damaged, bruised or scarred, or into areas with visible veins.

Now, clean the skin with the alcohol wipe.

Do not touch the injection site again or blow on it before the injection. Let your skin dry before injection.

Pick up the pen by holding the middle of the pen body with the needle pointing away from you. With your other hand, pull the cap straight off.

Once you have removed the cap, do not put it back on.

• [SUPER] Do not twist the cap off
• [SUPER] Do not remove the cap until you are ready to inject
• [SUPER] Do not press or touch the needle cover with your fingers, the needle is inside
• [SUPER] Do not try to put the cap back on once you’ve removed it

Place the needle cover on the skin at approximately a 90-degree angle. Make sure you can see the injector window.

Press down and hold the pen firmly against the skin until you can no longer see the needle cover. There will be a “click” when the injection starts.

As you hold the pen firmly against the skin, the injector window will start to turn yellow. The injection can take up to 20 seconds.

• [SUPER] Be sure to watch the window turn fully yellow.
• You will hear a second “click”. Check to see if the entire window has turned yellow. Keep the pen pressed against your skin as you count to 5 to ensure you are getting a full dose of DUPIXENT and lift the pen straight up off the skin.
• [SUPER] Keep the pen pressed against your skin as you count to 5 to ensure you are getting a full dose of DUPIXENT.

That’s it!

If the window does not turn fully yellow, remove the pen and call your healthcare provider. Do not give a second dose without speaking to your healthcare provider.

Lightly press a cotton ball or gauze on the injection site if you see any blood. You can also cover the site with a bandage. If the bleeding doesn’t stop, contact your healthcare provider.

• [SUPER] Do not rub your skin after the injection.

Be sure to put the used pen and its cap into a puncture-resistant sharps disposal container right away after use.

• [SUPER] Your puncture resistant disposal container may look different than the one shown here.
• [SUPER] Do not re-use the pre-filled pen
• [SUPER] Do not dispose of pre-filled pens in your household trash
• [SUPER] Do not recycle your used puncture-resistant container
• [SUPER] Keep your sharps disposal container out of the reach of children

Follow your local guidelines and ask your pharmacy or healthcare provider for the appropriate way to dispose of your used pen.

Be sure to keep track of your injection date and site.

To Camera:

Thank you for joining us today.

Remember, you can re-watch this video as often as you like to refresh your memory.

Contact your healthcare provider or the DUPIXENT MyWay Hotline with questions.