About Persistent Asthma

A hope for asthma

Have you thought about a life with less asthma? It’s important to
understand the current level of your asthma control.

Evolving Asthma Science

Scientific advances have found that excessive Type 2 inflammation is one of the major sources of persistent moderate-to-severe asthma.

Asthma that is caused by Type 2 inflammation is known as Type 2 asthma. With this type of asthma, there’s a constant underlying inflammation in the lungs, regardless of whether you or your child have any symptoms.

When breathing in something like pet dander or other allergens, the immune system reacts aggressively and increases inflammation. This can cause asthma symptoms to get worse and can result in an attack.

8 of 10 asthma patients

have Type 2 inflammation

How an Asthma Attack Feels

Hear from DUPIXENT patients as they describe what it feels like when they experience an asthma attack. Does their description sound similar to your experience?

Transcript

VO:

DUPIXENT (dupilumab) is a prescription medicine used with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in people aged 6 years and older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems. It is not known if DUPIXENT is safe and effective in children with asthma under 6 years of age.

Important Safety Information

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Please see additional Important Safety Information throughout this video and adjacent links for Full Prescribing information.

Before starting DUPIXENT, you should talk to your doctor about all the medical conditions you have or medications you are taking.

You and your doctor should also discuss the potential benefits and risks of treatment with DUPIXENT including the most common side effects such as injection site reactions, and some serious side effects such as allergic reactions including anaphylaxis and inflammation of your blood vessels.

RACHEL:

When I start having an asthma attack, I feel immediately exhausted.

MARLENA:

It’s similar to trying to blow out of a straw, if you could imagine the very little amount of air that you can actually blow through a straw.

RACHEL:

My chest starts feeling tight and feels very heavy. I get a little cough and wheeze.

PAMELA:

I equate it to how someone may feel if they’re drowning. You’re just trying to grasp for breath. It's like someone is taking your lungs and just squeezing them, and it's extremely scary.

RACHEL:

Then, you notice the wheeze isn’t going away. The tightness isn’t going away, and you- you kind of freeze.

MARLENA:

And you’re hot, and you’re sweaty, and you just can’t get any air, and it feels like a fish out of water.

PAMELA:

You try not to panic, and you tell yourself to be calm, but you're still panicking because you can't breathe.

MARLENA:

That’s how I would describe an asthma attack.

VO:

Important Safety
Information and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have a parasitic (helminth) infection
  • are scheduled to receive any vaccinations. You should not receive a "live vaccine" if you are treated with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions (hypersensitivity), including a severe reaction known as anaphylaxis. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following symptoms: breathing problems, fever, general ill feeling, swollen lymph nodes, swelling of the face, mouth and tongue, hives, itching, fainting, dizziness, feeling lightheaded (low blood pressure), joint pain, or skin rash.
  • Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, shortness of breath, persistent fever, chest pain, or a feeling of pins and needles or numbness of your arms or legs.

The most common side effects in patients with asthma include injection site reactions, pain in the throat (oropharyngeal pain), high count of a certain white blood cell (eosinophilia), and parasitic (helminth) infections.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider. In children 12 years of age and older, it’s recommended DUPIXENT be administered by or under supervision of an adult. In children under 12 years of age, DUPIXENT should be given by a caregiver.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in people aged 6 years and older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems. It is not known if DUPIXENT is safe and effective in children with asthma under 6 years of age.

These are Signs of Uncontrolled Asthma

If you don't think your or your child’s asthma is controlled, take the opportunity to get more information about DUPIXENT and fill out our discussion guide to talk to your doctor about whether DUPIXENT is an option.

Learn more about Dupixent

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Identify the Signs of Control

Here are a few key factors that may indicate that your
or your child’s persistent, moderate-to-severe asthma
isn’t well controlled:

In the past month, sleep has been interrupted because of asthma
A hospitalization because of asthma occurred at least once in the past year
Activities were limited or missed because of an attack
Rescue inhaler use is more than twice a week

Does any of this sound familiar?

Yes, it Does

I tried the inhalers and the steroids, the oral medications, and the injectables.

- Marlena, DUPIXENT MyWay® Patient Ambassador

Individual results may vary.

Watch Marlena’s story