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HOW DUPIXENT WORKS

Ready To DU More With Less Asthma?

Improves lung function
for long lasting
breathing relief

Targets two of the key
sources of airway inflammation

Not an inhaler,
not a steroid or
immunosuppressant

How DUPIXENT Works In The Lungs

Did you know, underlying inflammation may be ongoing even when asthma symptoms are not present?

Underlying inflammation in asthma may cause airways to become constricted and narrow, making it harder to breathe properly. 

DUPIXENT blocks 2 of the key sources of airway inflammation in the lungs and has shown long lasting breathing relief.

Provided for illustrative purposes only. Individual results may vary.

Transcript

A LOOK INSIDE: THE SCIENCE OF DUPIXENT

Please make sure to stay tuned for full indication and additional Important Safety Information.

Hi there! I’m Pixi, and I help people learn about DUPIXENT.

Today, I’d like to help you understand how DUPIXENT works in your body to improve lung function so you can breathe better in as little as two weeks.

Let’s use an analogy. It might be helpful to think of your asthma symptoms like spam calls.

Both are unwanted, persistent, and can disrupt your daily life.

Meet Mike, just an average cell phone that’s going to help us with this analogy.

He’s trying to relax when...
Poor Mike!

Unwanted interruptions can make mornings tough.

And Mike’s constant spam calls make simple activities, such as getting a good start to the day, walking in the park, and meeting up with friends harder.

Just like your asthma symptoms can make the everyday things you want to do feel like “uphill” tasks.

Frankly, it’s exhausting!

Right now, Mike has no way of blocking these unwanted spam calls.

He needs a spam filter!

Similarly, you may have no way of blocking the unwanted signals in your lungs that can cause asthma symptoms.

See, you may have Type 2 inflammation. 8 out of 10 people with asthma do!

It means there’s a constant underlying inflammation in your lungs caused by immune cells sending out too many inflammatory signals.

All this extra signaling causes the muscles in the lungs to contract and produce too much mucus, narrowing your airways and reducing air flow.

Unlike oral steroids, DUPIXENT targets an underlying source of this inflammation.

It works by attaching to certain proteins on immune cells to block some of the inflammatory signals that contribute to asthma.

So just like adding a spam filter could help Mike reduce his spam calls, adding DUPIXENT can help you reduce your asthma symptoms.

In fact, DUPIXENT was proven to help reduce asthma attacks by up to 81%.

And in a study of people who needed oral steroids, 86% of people reduced or eliminated their oral steroid dose.

The most common side effects in patients with asthma include injection site reactions, high count of a certain white blood cell (eosinophilia), pain in the throat (oropharyngeal pain), and parasitic (helminth) infections.

With his newly-installed spam filter, Mike gets fewer spam calls and can do more of what he loves. What could you do with less asthma?

If your current therapy isn’t doing enough, talk to your doctor about DUPIXENT, the first-of-its-kind asthma treatment proven to help patients breathe better in as little as two weeks. Stay tuned for additional Important Safety Information.

Important Safety
Information and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have a parasitic (helminth) infection
  • are scheduled to receive any vaccinations. You should not receive a "live vaccine" right before and during treatment with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
  • Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
  • Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects in patients with asthma include injection site reactions, high count of a certain white blood cell (eosinophilia), pain in the throat (oropharyngeal pain), and parasitic (helminth) infections.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider. In children 12 years of age and older, it’s recommended DUPIXENT be administered by or under supervision of an adult. In children 6 to less than 12 years of age, DUPIXENT should be given by a caregiver.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in adults and children 6 years of age and older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems. It is not known if DUPIXENT is safe and effective in children with asthma under 6 years of age.

A Look Inside: The Science of DUPIXENT

Discover how DUPIXENT works within the body to target
airway inflammation, combat asthma symptoms, and
help to improve breathing.

WHEN SHOULD YOU CONSIDER DUPIXENT?

Hear real DUPIXENT patients Rachel and Sharron share their
struggles with asthma and what led them to DUPIXENT as a
treatment option.

Use This Brochure to Learn
More About DUPIXENT

Download in English Descargar En Español

Transcript

SHARRON: I have lived with severe asthma most of my life. It developed early on when I was in middle school, and then as an adult, I had to use my rescue inhaler very frequently and the nebulizer as well.

RACHEL: I was diagnosed with severe asthma at the age of ten.

I had a lot of coughing, wheezing, feeling short of breath. My chest would get tight. We tried a lot of different asthma medications, but I would still end up in the hospital a couple of times a year. It had a really big impact on my life.

SHARRON: So, I love to sing, and singing was challenging to carry a note all the way through. I just couldn’t breathe. It was just hard to breathe.

RACHEL: The hardest thing to deal with was my wheezing. It was all the time. If we were sitting in a quiet classroom, the people next to me could hear me wheezing.

SHARRON: My asthma was not under control. Every day I woke up knowing that there’s a chance that I could have a severe asthma attack and go to the ER. It was definitely a weight on my mind with living like that, and I felt hopeless.

RACHEL: I had a really bad asthma attack when I was twenty-five years old that resulted in me being in the hospital for a week and after that, I was like, “Enough is enough!” I have to do something more to control my asthma.

SHARRON: So, my doctor treated my asthma with rescue inhalers, anti-inflammatories, oral steroids and long-acting inhalers. They weren’t managing the asthma well; it was not controlled.

One day on a follow-up appointment, my doctor brought up DUPIXENT as an add-on therapy. He talked about it being a biologic, what that was, and I was ready for it.

If there was a chance that it could help control my asthma, then I was ready for it and willing to do whatever I needed to do.

RACHEL: When my doctor suggested DUPIXENT, I was open to it. We had a candid conversation. I asked a lot of questions. She explained to me what was going on in my body and that DUPIXENT could work for patients like me, so I wanted to try it.

RACHEL: Before I started DUPIXENT, I told my doctor about all the medical conditions I had and medications I was taking.

SHARRON: My doctor and I talked about the potential benefits and risks of treatment, including the most common side effects such as injection site reactions, and some serious side effects including allergic reactions that can sometimes be severe, inflammation of your blood vessels, and joint aches and pain.

RACHEL: After starting DUPIXENT, I was able to do some of my simple, everyday activities without my asthma getting in the way as often, like running around the yard with my dogs, helping with the outdoor chores.

SHARRON: Over time I noticed that the wheezing decreased. I didn’t have to use my rescue inhaler as often, and I think the best of all was that I was able to sing and hold the note.

RACHEL: I never thought that I would be where I am in my asthma journey. It’s a very good feeling. I feel a lot of relief knowing that my asthma is better controlled.

SHARRON: It feels great to be able to manage my asthma better.

RACHEL: I’ve learned to be a good advocate for myself and that I do not have to accept uncontrolled asthma.

VO:

Important Safety
Information and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have a parasitic (helminth) infection
  • are scheduled to receive any vaccinations. You should not receive a "live vaccine" right before and during treatment with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
  • Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
  • Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects in patients with asthma include injection site reactions, high count of a certain white blood cell (eosinophilia), pain in the throat (oropharyngeal pain), and parasitic (helminth) infections.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider. In children 12 years of age and older, it’s recommended DUPIXENT be administered by or under supervision of an adult. In children 6 to less than 12 years of age, DUPIXENT should be given by a caregiver.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in adults and children 6 years of age and older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems. It is not known if DUPIXENT is safe and effective in children with asthma under 6 years of age.

BENEFITS WITH EVERY BREATH

Explore the results of DUPIXENT.

Results in patients
12+ Years
Results in patients
6-11 Years

frequently asked questions

DUPIXENT targets two of the key sources of airway inflammation in your lungs to help prevent asthma attacks and reduce asthma symptoms. DUPIXENT is not a steroid or inhaler.

Learn more about
uncontrolled asthma

Do not use DUPIXENT if you are allergic to dupilumab or to any of the ingredients in DUPIXENT.

Inactive ingredients: L-arginine hydrochloride, L-histidine, polysorbate 80, sodium acetate, sucrose, and water for injection.

Before using DUPIXENT, tell your doctor about all your medical conditions, including if you:

  • have a parasitic (helminth) infection
  • are scheduled to receive any vaccinations. You should not receive a "live vaccine" right before and during treatment with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine to come back.

DUPIXENT was studied in the VENTURE trial, where 86% of patients reduced or eliminated their oral steroid dose with DUPIXENT 300 mg + Standard of Care (SOC) vs 68% with placebo + SOC.

Do not stop taking your corticosteroid medicines unless instructed by your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine to come back.

The most common side effects include injection site reactions, high count of a certain white blood cell (eosinophilia), and pain in the throat (oropharyngeal pain).

View the possible side effects of DUPIXENT in patients with moderate-to-severe eosinophilic or oral corticosteroid dependent asthma below.

View the possible side effects