FREQUENTLY ASKED QUESTIONS

DUPIXENT is a prescription medicine used as an add-on maintenance treatment for adults and children 6 years of age and older who have moderate-to-severe eosinophilic or oral steroid dependent asthma that is not controlled with their current asthma medicines. DUPIXENT is not used to treat sudden breathing problems.

Asthma is a chronic inflammatory condition. DUPIXENT blocks two key sources of inflammation in your lungs to help prevent asthma attacks and reduce asthma symptoms. DUPIXENT is not a steroid or inhaler.

Do not use DUPIXENT if you are allergic to dupilumab or to any of the ingredients in DUPIXENT.

In clinical trials, the impact of DUPIXENT on lung function was studied in patients 6 to 11 years of age and patients 12 years of age and older. Patients in each age group saw improved lung function in as little as 2 weeks.

Learn more about these trials and how DUPIXENT may help treat your symptoms.

The efficacy and safety of DUPIXENT was tested in 3 well-controlled clinical studies of more than 2,800 patients 12 years of age or over with moderate-to-severe asthma. DUPIXENT was evaluated in these studies when taken with either inhaled or oral corticosteroids. In one of the studies, the effect of DUPIXENT on tapering oral corticosteroids was studied.

In pediatric patients, the efficacy and safety of DUPIXENT was studied in a well-controlled pediatric study of 408 participants, 6 to 11 years of age, with moderate-to-severe asthma. The patients in the study were either on a medium or high-dose inhaled corticosteroid (ICS) and a second controller medication, or a high-dose ICS alone.

DUPIXENT can cause serious side effects, including:

• Allergic reactions. DUPIXENT can cause reactions that can sometimes be severe. Stop using DUPIXENT and go to the nearest hospital emergency room if you get any of the following symptoms:

• Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have:

• Joint aches and pain. Joint aches and pain can happen in people who use DUPIXENT. Some people have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects of DUPIXENT include:

• injection site reactions
• pain in the throat (oropharyngeal pain)
• high count of a certain white blood cell (eosinophilia)
• parasitic (helminth) infections

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

DUPIXENT is given as an injection under the skin (subcutaneous injection) at different injection sites. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider.

Talk to your healthcare provider and see the detailed Instructions for Use that come with DUPIXENT for information on how to prepare and inject DUPIXENT and how to properly store and throw away (dispose of) used DUPIXENT Pre-filled Syringes or DUPIXENT Pre-filled Pens prior to taking the drug. The DUPIXENT Pre-filled Pen is only in use for adults and children 6 years of age and older.

Watch videos, learn how to administer DUPIXENT, and more.

GET THE PRE-FILLED SYRINGE INSTRUCTIONS FOR USE

GET THE PRE-FILLED PEN (AGES 6+ YEARS) INSTRUCTIONS FOR USE

GET THE PRE-FILLED SYRINGE INSTRUCTIONS FOR USE

GET THE PRE-FILLED PEN (AGES 6+ YEARS) INSTRUCTIONS FOR USE

If your dose schedule is every 4 weeks and you miss a dose of DUPIXENT: Give the DUPIXENT injection within 7 days from the missed dose, then continue with your original schedule. If the missed dose is not given within 7 days, start a new every 4 week dose schedule from the time you remember to take your DUPIXENT injection.

If your dose schedule is every other week and you miss a dose of DUPIXENT: Give the DUPIXENT injection within 7 days from the missed dose, then continue with your original schedule. If the missed dose is not given within 7 days, wait until the next scheduled dose to give your DUPIXENT injection.

No, you should always follow your healthcare provider’s instructions for dosing and how to give injections.

DUPIXENT should be refrigerated at 36 °F to 46 °F (2 °C to 8 °C) in the original carton to protect from light. If necessary, DUPIXENT may be kept at room temperature up to 77°F (25°C) for a maximum of 14 days. Do not store above 77°F (25° C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded.

Do not expose DUPIXENT to heat or direct sunlight.

Do not freeze. Do not shake.

Please refer to the DUPIXENT Instructions for Use for complete storage instructions.

Whether you are traveling or not, it’s important to store DUPIXENT in the original carton to protect it from light.

Store refrigerated at 36°F to 46°F (2°C to 8°C) in the original carton to protect from light. If necessary, DUPIXENT may be kept at room temperature up to 77°F (25°C) for a maximum of 14 days. Do not store above 77°F (25°C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded.

Yes. You can continue to receive injection support from your doctor or our Injection Support Center or, if your doctor decides that you or your caretaker can give injections, your doctor will train you. Do not self-adminster DUPIXENT unless you have been trained by a doctor. Patients enrolled in DUPIXENT MyWay® will also have access to their Nurse Educator to help with supplemental training.

For more information about DUPIXENT support resources, you can enroll in DUPIXENT MyWay®, a program that can provide:

• Tips and tools to help with your uncontrolled moderate-to-severe asthma
• Supplemental injection training. Your doctor will show you the proper procedure first and decide whether you can self-inject.
• Financial support for eligible commercially insured patients
• Assistance with insurance questions
• Assistance locating a pharmacy that can dispense your DUPIXENT prescription

Sign up or call a support coordinator at 1-844-DUPIXENT (1-844-387-4936) to learn more.

You can use our Cost and Coverage Tool to learn more about cost options for your insurance situation. For the most accurate information regarding your cost and dispensing of DUPIXENT, speak directly with your insurance provider, who knows the details of your plan.

DUPIXENT is likely to be accessed differently than your other medications. DUPIXENT is an injectable medication that requires special shipping and handling. Insurance providers often require use of a specialty pharmacy instead of your local retail pharmacy. DUPIXENT MyWay® can work with your insurance provider to identify a preferred, in-network specialty pharmacy.

Notify your pharmacy. In fact, when you take medications that require refills regularly, it’s always good to periodically check that your pharmacy has your most up-to-date insurance information on file. This can help you avoid potential delays in getting your prescription.

Contact 1-844-DUPIXENT (1-844-387-4936) to speak to a DUPIXENT MyWay® Nurse Educator if you have additional questions.

With the DUPIXENT MyWay Copay Card, eligible commercially insured patients may pay as little as $0* copay per fill of DUPIXENT (maximum of $13,000 per patient per calendar year) if they meet the eligibility requirements, including:

• Have commercial insurance, including health insurance exchanges, federal employee plans, or state employee plans
• Are a resident of the 50 United States, the District of Columbia, Puerto Rico, Guam, or the USVI
• Are prescribed DUPIXENT for an indication approved by the US Food and Drug Administration

*Approval is not guaranteed. Program has an annual maximum of $13,000. THIS IS NOT INSURANCE. Not valid for prescriptions paid, in whole or in part, by Medicaid, Medicare, VA, DOD, TRICARE, or other federal or state programs including any state pharmaceutical assistance programs. This program is not valid where prohibited by law, taxed, or restricted. DUPIXENT MyWay reserves the right to rescind, revoke, terminate, or amend this offer, eligibility, and terms of use at any time without notice. Any savings provided by the program may vary depending on patients' out-of-pocket costs. The program is intended to help patients afford DUPIXENT. Patients may have insurance plans that attempt to dilute the impact of the assistance available under the program. In those situations, the program may change its terms. Additional terms and conditions apply.

If your health plan did not accept the copay card or if you paid the copay because you were not enrolled in this program, we may be able to reimburse you in accordance with program terms.

Submit your request for reimbursement.

Through the Patient Assistance Program, eligible patients who are uninsured or whose insurance does not cover DUPIXENT could receive DUPIXENT free of charge.

Those who may qualify must be at least 18 years of age or older, a resident of the 50 United States, the District of Columbia, Puerto Rico, Guam, or the USVI, and demonstrate a financial need with a total annual adjusted gross income of $100,000 or less.

The DUPIXENT MyWay team will research each patient’s situation and determine eligibility. For more information, call 1‑844‑DUPIXENT (1-844-387-4936), option 1.