DUPIXENT is indicated for the treatment of adults and children aged 6 months and older with moderate-to-severe atopic dermatitis (eczema) whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. DUPIXENT can be used with or without topical corticosteroids.
Get the factsFill out your personalized doctor discussion guide and ask your doctor if DUPIXENT may be right for you.
DUPIXENT works with your body’s immune system to help reduce inflammation contributing to your eczema, which may help reduce your uncontrolled moderate-to-severe eczema (atopic dermatitis) symptoms and may give you noticeably clearer skin.
Please see How Dupixent WorksDo not use DUPIXENT if you are allergic to dupilumab or to any of the ingredients in DUPIXENT.
Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:
Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or if you have atopic dermatitis and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.
The efficacy of DUPIXENT has been studied in 3 clinical trials with approximately 2,100 adults with uncontrolled moderate-to-severe atopic dermatitis.
The efficacy of DUPIXENT has been studied in a 16-week clinical trial with 251 teens ages 12-17 years with uncontrolled moderate-to-severe atopic dermatitis.
The efficacy of DUPIXENT has been studied in a 16-week clinical trial with 367 children ages 6-11 years with uncontrolled severe atopic dermatitis also taking topical corticosteroids.
The efficacy of DUPIXENT has been studied in a 16-week clinical trial with 162 children ages 6 months-5 years with uncontrolled moderate-to-severe atopic dermatitis also taking topical corticosteroids.
Patients enrolled in these studies were not well controlled with prescription therapies used on the skin (topical), or could not use topical therapies.
View Results inIndividual responses to DUPIXENT can vary. Your experience with DUPIXENT may be different.
DUPIXENT has been studied in multiple clinical trials with various age groups—Adults (ages 18+ years), Teens (ages 12-17 years), Children (ages 6-11 years), and Young Children (ages 6 months-5 years)—who suffer from uncontrolled moderate-to-severe eczema (atopic dermatitis).
In each clinical trial, results were measured at 16 weeks, with each age group taking DUPIXENT achieving visible skin improvement in that time compared to patients who were not administered DUPIXENT.
View Results inDUPIXENT can cause serious side effects, including:
The most common side effects of DUPIXENT include:
Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:
Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or if you have atopic dermatitis and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.
DUPIXENT works by blocking the signaling of two proteins that contribute to a type of inflammation that plays a major role in atopic dermatitis.
DUPIXENT affects the body’s immune system to help reduce the inflammation associated with moderate-to-severe eczema, which may reduce symptoms such as rash, redness, and itch. It is not known if DUPIXENT can affect the immune response to parasitic (helminth) infections.
DUPIXENT is given as an injection under the skin (subcutaneous injection) at different injection sites. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider. In teens 12 years of age or older, it is recommended that DUPIXENT be administered by or under the supervision of an adult. In children younger than 12 years of age, DUPIXENT should be given by a caregiver. The DUPIXENT pre-filled pen is only for use in adults and children 12 years of age and older. The DUPIXENT pre-filled syringe is for use in adults and children 6 months of age and older.
Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it.
The recommended dose of DUPIXENT is specified in the table below. DUPIXENT can be used with or without topical corticosteroids.
Body Weight | Initial Loading Dose | Subsequent Dosage |
---|---|---|
Adults 18+ | ||
Any weight | 600 mg (two 300-mg injections) | 300 mg; every 2 weeks |
Children and Teens 6-17 Years Old | ||
132 lb or more | 600 mg (two 300-mg injections) | 300 mg; every 2 weeks |
66 lb to under 132 lb | 400 mg (two 200-mg injections) | 200 mg; every 2 weeks |
33 lb to under 66 lb | 600 mg (two 300-mg injections) | 300 mg; every 4 weeks |
Body Weight | Initial* and Subsequent Dosage |
---|---|
Children 6 Months-5 Years Old | |
33 lb to under 66 lb | 300 mg; every 4 weeks |
11 lb to under 33 lb | 200 mg; every 2 weeks |
*For children 6 months to 5 years of age with atopic dermatitis, no initial loading dose is recommended.
Get supplemental injection support after your doctor shows you the right way to take DUPIXENT.
Visit the injectionGet the Pre-filled syringe Instructions for use
Get the Pre-filled Pen (AGES 12+ YEARS) Instructions for use
DUPIXENT can be injected into the thigh, stomach (except for the 2 inches around the belly button), or outer area of the upper arm (if caregiver injects). A different site should be chosen each time DUPIXENT is injected.
Get the Pre-filled syringe Instructions for use
Get the Pre-filled Pen (AGES 12+ YEARS) Instructions for use
If your dose schedule is every other week and you miss a dose of DUPIXENT: Give the DUPIXENT injection within 7 days from the missed dose, then continue with your original schedule. If the missed dose is not given within 7 days, wait until the next scheduled dose to give your DUPIXENT injection.
If your dose schedule is every 4 weeks and you miss a dose of DUPIXENT: Give the DUPIXENT injection within 7 days from the missed dose, then continue with your original schedule. If the missed dose is not given within 7 days, start a new every 4 week dose schedule from the time you remember to take your DUPIXENT injection.
Speak with your healthcare provider before making any change to your treatment regimen.
set up injection remindersNo, you should always follow your healthcare provider’s instructions for dosing and how to give injections.
Moderate-to-severe eczema is a chronic disease with no known cure. Each person may respond differently to DUPIXENT. Speak with your healthcare provider if you have questions regarding how long you’ll need to take DUPIXENT.
There are no known foods you should avoid while taking DUPIXENT. If you suspect a side effect with a particular food while taking DUPIXENT, notify your healthcare provider.
Be sure to speak with your healthcare provider.
DUPIXENT should be refrigerated at 36°F to 46°F in the original carton to protect from light. If necessary, DUPIXENT may be kept at room temperature up to 77°F (25°C) for a maximum of 14 days. Do not store above 77°F (25°C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded.
Do not expose DUPIXENT to heat or direct sunlight.
Do not freeze. Do not shake.
Please refer to the DUPIXENT Instructions for Use for complete storage instructions.
Whether you are traveling or not, it’s important to store the syringes in the original carton to protect them from light.
Store refrigerated at 36°F to 46°F (2°C to 8°C) in the original carton to protect from light. If necessary, pre‑filled syringes and pre‑filled pens may be kept at room temperature up to 77°F (25°C) for a maximum of 14 days. Do not store above 77°F (25°C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded.
Yes. You can continue to receive injection support from your doctor or our Injection Support Center, or if your doctor decides that you or your caretaker can give injections, your doctor will train you. Do not self-administer DUPIXENT unless you have been trained by a doctor. Patients enrolled in DUPIXENT MyWay® will also have access to their Nurse Educator to help with supplemental training.
For more information about DUPIXENT support resources, you can enroll in DUPIXENT MyWay®, a program that can provide:
Sign up or call a support coordinator at 1-844-DUPIXENT (1-844-387-4936) to learn more.
LEARN ABOUT DUPIXENT MyWayYou can use our Cost and Coverage Tool to learn more about cost information for your insurance situation. For the most accurate information regarding your cost and dispensing of DUPIXENT, speak directly with your insurance provider who knows the details of your plan.
use the cost and coverage toolCertain retail pharmacies or specialty pharmacies can fill your prescription. These pharmacies can:
Notify your pharmacy. In fact, when you take medications that require refills regularly over time, it’s always good to periodically check that your pharmacy has your most up-to-date insurance information on file. This can help you avoid potential delays in getting your prescription.
Contact 1-844-DUPIXENT (1-844-387-4936) to speak to a DUPIXENT MyWay® Nurse Educator if you have additional questions.
With the DUPIXENT MyWay Copay Card, eligible, commercially insured patients may pay as little as $0* copay per fill of DUPIXENT (maximum of $13,000 per patient per calendar year) if they meet the eligibility requirements, including:
You can request copay reimbursement if:
Submit your request for reimbursement.
GET STARTEDThrough the Patient Assistance Program, qualified patients who are uninsured or whose insurance does not cover DUPIXENT could receive DUPIXENT at no cost.
Those who may qualify must be at least 18 years of age or older, a resident of the 50 United States, the District of Columbia, Puerto Rico, Guam or the USVI, and demonstrate a financial need with a total annual adjusted gross income of $100,000 or less.
The DUPIXENT MyWay team will research each patient’s situation and determine eligibility. For more information, call 1-844-DUPIXENT (1-844-387-4936), option 1.