FREQUENTLY ASKED
QUESTIONS

DUPIXENT is a biologic medication indicated for the treatment of 8 conditions:

• Uncontrolled moderate-to-severe eczema (atopic dermatitis or AD) for ages 6+ months
• Add-on maintenance treatment for uncontrolled moderate-to-severe eosinophilic or oral steroid dependent asthma for
  ages 6+ years
  • DUPIXENT is not used to relieve sudden breathing problems and will not replace an inhaled rescue medicine.
• Add-on maintenance treatment for inadequately controlled chronic obstructive pulmonary disease (COPD) with high blood eosinophils for ages 18+ years
  • DUPIXENT is not used to relieve sudden breathing problems and will not replace an inhaled rescue medicine.
• Add-on maintenance treatment for uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) for ages 12+ years
• Eosinophilic esophagitis (EoE) for ages 1+ years, who weigh at least 33 lb (15 kg)
• Prurigo nodularis (PN) for ages 18+ years
• Chronic spontaneous urticaria (CSU) with hives not controlled by H1 antihistamines for ages 12+ years
  • DUPIXENT is not used to treat any other forms of hives (urticaria).
• Bullous pemphigoid (BP) for ages 18+ years

Biologics are specialty medicines made inside living cells and designed to target specific parts of the immune system involved in a particular disease. They are processed in the body differently than oral or topical medications. To be effective and work properly, most biologics are delivered by injection.

DUPIXENT blocks the signaling of two key sources of Type 2 inflammation (IL-4 and IL-13). This inflammation is an important
component in the development of asthma, eczema, chronic obstructive pulmonary disease, chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis, chronic spontaneous urticaria, and bullous pemphigoid.

To learn more, explore our How DUPIXENT Works pages for your condition:

• Uncontrolled moderate-to-severe eczema (atopic dermatitis or AD) for ages 6+ months
• Add-on maintenance treatment for uncontrolled moderate-to-severe eosinophilic or oral steroid dependent asthma for
  ages 6+ years
  • DUPIXENT is not used to relieve sudden breathing problems and will not replace an inhaled rescue medicine.
• Add-on maintenance treatment for inadequately controlled chronic obstructive pulmonary disease (COPD) with high blood eosinophils for ages 18+ years
  • DUPIXENT is not used to relieve sudden breathing problems and will not replace an inhaled rescue medicine.
• Add-on maintenance treatment for uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) for ages 12+ years
• Eosinophilic esophagitis (EoE) for ages 1+ years, who weigh at least 33 lb (15 kg)
• Prurigo nodularis (PN) for ages 18+ years
• Chronic spontaneous urticaria (CSU) with hives not controlled by H1 antihistamines for ages 12+ years
  • DUPIXENT is not used to treat any other forms of hives (urticaria).
• Bullous pemphigoid (BP) for ages 18+ years

Do not use DUPIXENT if you are allergic to dupilumab or to any of the ingredients in DUPIXENT.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

• Have eye problems.
• Have a parasitic (helminth) infection.
• Are scheduled to receive any vaccinations. You should not receive a “live vaccine” right before and during treatment with
  DUPIXENT.
• Are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • A pregnancy registry for women who take DUPIXENT during pregnancy collects information about the health of you and
    your baby. To enroll or get more information call 1-877-311-8972 or go to https://mothertobaby.org/​​​ongoing-study/​​dupixent/​.
• Are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines; have asthma and use an asthma medicine; or have AD, CRSwNP, EoE, PN, COPD, CSU, or BP and also have asthma. Do not change or stop your other medicines, including corticosteroid medicine or other asthma medicine, without talking to your healthcare provider. This may cause other symptoms that were controlled by those medicines to come back.

DUPIXENT can cause serious side effects, including:

• Allergic reactions. DUPIXENT can cause allergic reactions, including skin reactions, that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms:

• Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an eye exam if needed.
• Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. Tell your healthcare provider right away if you get: rash, chest pain, worsening shortness of breath, brown or dark colored urine, persistent fever, or a feeling of pins and needles or numbness of your arms or legs.
• Psoriasis. This can happen in people with atopic dermatitis and asthma who receive DUPIXENT. Tell your healthcare provider about any new skin symptoms. Your healthcare provider may send you to a dermatologist for an examination if needed. 
• Joint aches and pain. Joint aches and pain can happen in people who use DUPIXENT. Some people have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects of DUPIXENT include:

• Eczema: injection site reactions, eye problems, including eye and eyelid inflammation, redness, swelling, itching, eye infection, dry eye, and blurred vision, cold sores in your mouth or on your lips, and high count of a certain white blood cell (eosinophilia).
• Asthma: injection site reactions, high count of a certain white blood cell (eosinophilia), pain in the throat (oropharyngeal pain), and parasitic (helminth) infections.
• Chronic Rhinosinusitis with Nasal Polyps: injection site reactions, eye problems, including eye and eyelid inflammation, redness, swelling, itching, eye infection, and blurred vision, high count of a certain white blood cell (eosinophilia), stomach problems (gastritis), joint pain (arthralgia), trouble sleeping (insomnia), and toothache.
• Eosinophilic Esophagitis: injection site reactions, upper respiratory tract infections, cold sores in your mouth or on your lips, and joint pain (arthralgia).
• Prurigo Nodularis: eye problems, including eye and eyelid inflammation, redness, swelling, itching, and blurred vision, herpes virus infections, common cold symptoms (nasopharyngitis), dizziness, muscle pain, and diarrhea.
• Chronic Obstructive Pulmonary Disease: injection site reactions, common cold symptoms (nasopharyngitis), high count of a certain white blood cell (eosinophilia), viral infection, back pain, inflammation inside the nose (rhinitis), diarrhea, stomach problems (gastritis), joint pain (arthralgia), toothache, headache, and urinary tract infection.
• Chronic Spontaneous Urticaria: injection site reactions.
• Bullous Pemphigoid: joint pain (arthralgia), eye problems, including eye and eyelid inflammation, redness, swelling, itching, and blurred vision, and herpes virus infections.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the
possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report
negative side effects to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

• Have eye problems.
• Have a parasitic (helminth) infection.
• Are scheduled to receive any vaccinations. You should not receive a “live vaccine” right before and during treatment with
  DUPIXENT.
• Are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • A pregnancy registry for women who take DUPIXENT during pregnancy collects information about the health of you and
    your baby. To enroll or get more information call 1-877-311-8972 or go to https://mothertobaby.org/ongoing-study/dupixent/.
• Are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines,
vitamins, and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines; have asthma and use an asthma medicine; or have AD, CRSwNP, EoE, PN, COPD, CSU, or BP and also have asthma. Do not change or stop your other medicines, including corticosteroid medicine or other asthma medicine, without talking to your healthcare provider. This may cause other symptoms that were controlled by those medicines to come back.

DUPIXENT is given as an injection under the skin (subcutaneous injection) at different injection sites. Do not try to inject
DUPIXENT until you have been shown the right way by your healthcare provider. In children 12 years of age or older, it is
recommended that DUPIXENT be administered by or under the supervision of an adult. In children 6 months to less than 12
years of age, DUPIXENT should be given by a caregiver. The DUPIXENT Pre-filled Pen is only for use in adults and children 2
years of age and older. The DUPIXENT Pre-filled Syringe is for use in adults and children 6 months of age and older.

Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it.

Get dosing information for each condition:

• Uncontrolled moderate-to-severe eczema (atopic dermatitis or AD)
• Uncontrolled moderate-to-severe eosinophilic or oral steroid dependent asthma
  • DUPIXENT is not used to relieve sudden breathing problems and will not replace an inhaled rescue medicine.
• Add-on maintenance treatment for inadequately controlled chronic obstructive pulmonary disease (COPD) with high blood eosinophils for ages 18+ years
  • DUPIXENT is not used to relieve sudden breathing problems and will not replace an inhaled rescue medicine.
• Uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP)
• Eosinophilic esophagitis (EoE)
• Prurigo nodularis (PN)
• Chronic spontaneous urticaria (CSU) with hives not controlled by H1 antihistamines for ages 12+ years
  • DUPIXENT is not used to treat any other forms of hives (urticaria).
• Bullous pemphigoid (BP) for ages 18+ years

Get the Pre-filled Syringe Instructions For Use

Get the Pre-filled Pen (Ages 2+ Years) Instructions For Use

DUPIXENT can be injected into the thigh, stomach (except for the 2 inches around the belly button), or outer area of the upper
arm (if caregiver injects). A different site should be chosen each time DUPIXENT is injected.

• Follow your healthcare provider’s instructions and read the Instructions for Use for full details on preparation,
  administration, and disposal of your injection.

Get the Pre-filled Syringe Instructions For Use

Get the Pre-filled Pen (Ages 2+ Years) Instructions For Use

Each shipment of DUPIXENT contains 2 doses. A single dose of DUPIXENT comes as 1 pre-filled pen or pre-filled syringe with a needle shield. Each DUPIXENT dose contains either 300 mg or 200 mg.

For patients taking DUPIXENT every 2 weeks, a shipment of 2 doses will arrive every month. Your DUPIXENT delivery may arrive more or less frequently depending on your dosing schedule.

If your dose schedule is every week and you miss a dose of DUPIXENT: Give the DUPIXENT injection as soon as possible and
start a new every-week dose schedule from the time you remember to take your DUPIXENT injection.

If your dose schedule is every 2 weeks and you miss a dose of DUPIXENT: Give the DUPIXENT injection within 7 days
from the missed dose, then continue with your original schedule. If the missed dose is not given within 7 days, start a new
every 2-week dose schedule from the time you remember to take your DUPIXENT injection.

If your dose schedule is every 4 weeks and you miss a dose of DUPIXENT: Give the DUPIXENT injection within 7 days from the
missed dose, then continue with your original schedule. If the missed dose is not given within 7 days, start a new every-4-week
dose schedule from the time you remember to take your DUPIXENT injection.

Speak with your healthcare provider before making any change to your treatment regimen.

It is important to take DUPIXENT consistent with the Prescribing Information. Always follow your healthcare provider’s instructions for dosing. Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it. Speak with your healthcare provider before making any change to your treatment regimen.

No, you should always follow your healthcare provider’s instructions for dosing and how to give injections.

Yes. You or your caregiver can continue to receive injection training support from your doctor or our Injection Support Center. Do not self-administer DUPIXENT unless you have been trained by a doctor. Patients enrolled in DUPIXENT MyWay® will also have access to DUPIXENT MyWay Nurse Educator to help with supplemental training after initial training with your doctor.

DUPIXENT MyWay® is a patient support program designed to help you start DUPIXENT as quickly as possible and stay on track with your treatment.

DUPIXENT MyWay provides insurance coverage support, financial assistance, and resources to help you understand your condition and DUPIXENT treatment. Once enrolled in the program, you can receive:

• Help with understanding your insurance coverage for DUPIXENT
• Financial assistance, including copay support, if eligible
• Supplemental injection training with DUPIXENT MyWay Nurse Educator
• Refill and injection reminders
• Tips and tools to help you manage treatment

To receive DUPIXENT MyWay support, talk to your doctor about enrolling. You can also speak with a DUPIXENT MyWay Case Manager at 1-844-DUPIXENT (1-844-387-4936) Option 1, Monday-Friday, 8 am-9 pm ET.

Each person may respond differently to DUPIXENT. Speak with your healthcare provider if you have questions regarding how
long you’ll need to take DUPIXENT.

There are no known foods that you should avoid while using DUPIXENT. If you suspect that you are experiencing a side effect caused by a particular food while using DUPIXENT, notify your healthcare provider.

Be sure to speak with your healthcare provider.

DUPIXENT should be refrigerated between 36 °F and 46 °F in the original carton to protect from light. If necessary, DUPIXENT may be
kept at room temperature up to 77 °F (25 °C) for a maximum of 14 days. Do not store above 77 °F (25 °C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded.

Do not heat or put DUPIXENT into direct sunlight.

Do not freeze. Do not shake.

Please refer to the DUPIXENT Instructions for Use for complete storage instructions.

Whether you are traveling or not, it’s important to store the syringes in the original carton to protect them from light.

Store refrigerated between 36 °F and 46 °F (2 °C and 8 °C) in the original carton to protect from light. If necessary, Pre-filled Syringes and Pre-filled Pens may be kept at room temperature up to 77 °F (25 °C) for a maximum of 14 days. Do not store above 77 °F (25 °C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded.

All prescription medications have a list price.* Very few patients pay the list price, which is a price set by the manufacturer. The list price of DUPIXENT is $4,193.03 USD per carton,^† but most people will not pay the list price.

You can use our Cost and Coverage Tool to learn more about cost information for your insurance situation. For the most accurate information regarding your cost and dispensing of DUPIXENT, speak directly with your insurance provider, who knows the details of your plan.

*List price is also referred to as wholesale acquisition cost or WAC. WAC is the price at which Sanofi sells its products to wholesalers. A monthly supply/carton of
 DUPIXENT (300 mg or 200 mg) is defined as 2 injections per month.

^†List price as of 1/2/2026.

DUPIXENT prescriptions are often filled by specialty pharmacies that can meet the appropriate storage and handling requirements. Once your health insurer approves your prescription, a specialty pharmacy will call you to schedule delivery to the agreed upon address. Your specialty pharmacy can:

• Coordinate directly with your doctor
• Manage the handling and service requirements of specialty drugs
• Ship your medication directly to your home in a special cooler to help make sure the correct temperature is maintained
  through the process
• Stay in contact with you and your doctor throughout the treatment

Your doctor's office or DUPIXENT MyWay® Case Manager can tell you which specialty pharmacy will be delivering your DUPIXENT prescription. If you're eligible for the DUPIXENT MyWay Copay Card, be sure to tell your specialty pharmacy.

If you experience a loss of coverage or change in insurance during treatment, DUPIXENT MyWay® can explore other options to assist with the cost of treatment.

Learn more by calling 1-844-DUPIXENT (1-844-387-4936).

With the DUPIXENT MyWay Copay Card, eligible patients with commercial health insurance may pay as little as $0* in copay per fill of DUPIXENT if they meet the eligibility requirements, including:

• Have commercial insurance, including health insurance exchanges, federal employee plans, or state employee plans
• Are a resident of the 50 United States, the District of Columbia, Puerto Rico, Guam, or the USVI
• Are prescribed DUPIXENT for an indication approved by the US Food and Drug Administration

*Subject to the program maximum per patient per calendar year. Approval is not guaranteed. THIS IS NOT INSURANCE. Not valid for prescriptions paid, in whole or in part, by Medicaid, Medicare, VA, DOD, TRICARE, or other federal or state programs, including any state pharmaceutical assistance programs. This program is not valid where prohibited by law, taxed, or restricted. DUPIXENT MyWay reserves the right to rescind, revoke, terminate, or amend this offer, eligibility, and terms of use at any time without notice. Any savings provided by the program may vary depending on patients’ out-of-pocket costs. The program is intended to help patients afford DUPIXENT. Patients may have insurance plans that attempt to dilute the impact of the assistance available under the program. In those situations, the program may change its terms. Additional terms and conditions apply.

You can request copay reimbursement if:

• Your health plan did not accept your copay card
• You paid a copay for DUPIXENT before enrolling in DUPIXENT MyWay® and you meet other program requirements

Submit your request for reimbursement.

The DUPIXENT MyWay Patient Assistance Program may be able to help you if you do not have health insurance, are experiencing difficulty paying for your DUPIXENT treatment or have Medicare Part D.

DUPIXENT MyWay reviews your situation and evaluates eligibility on a case-by-case basis. Find out if you qualify by speaking with a DUPIXENT MyWay Case Manager at 1-844-DUPIXENT (1-844-387-4936).

If you do not have insurance that covers your prescription medications, or if your insurance does not cover DUPIXENT, you can
typically expect to pay the list price shown above plus any additional pharmacy charges. The price you pay varies from
pharmacy to pharmacy.

If you need help paying for your prescription, the DUPIXENT MyWay® Patient Assistance Program may be able to help. Patients
will need to meet the eligibility criteria, including household income, to qualify. The DUPIXENT MyWay team can research each
patient's situation and determine eligibility.

If you have any additional questions about this pricing information, please call DUPIXENT MyWay at 1-844-DUPIXENT (1-844-387-4936).