Frequently Asked
Questions

DUPIXENT is a prescription medicine used to treat adults with prurigo nodularis (PN). It is not known if DUPIXENT is safe and effective in children with prurigo nodularis under 18 years of age.

DUPIXENT works with your body’s immune system to help reduce inflammation, which may help reduce the itch and lesions associated with prurigo nodularis.

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

The efficacy and safety of DUPIXENT has been studied in 2 clinical trials with 311 adults with prurigo nodularis.

Individual responses to DUPIXENT can vary. Your experience with DUPIXENT may be different. 

DUPIXENT has been studied in 2 clinical trials with 311 adults (ages 18+ years) with prurigo nodularis (PN).

In the clinical trials, results were measured at 24 weeks, with patients taking DUPIXENT achieving less itch compared to patients who were administered a placebo.

DUPIXENT can cause serious side effects, including:

• Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms:

• Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an eye exam if needed.

• Joint aches and pain. Some people have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

• Have eye problems.
• Have a parasitic (helminth) infection.
• Are scheduled to receive any vaccinations. You should not receive a “live vaccine” right before and during treatment with DUPIXENT.
• Are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • A pregnancy registry for women who take DUPIXENT during pregnancy collects information about the health of you and your baby. To enroll or get more information call 1-877-311-8972 or go to
    https://mothertobaby.org/ongoing-study/dupixent/.
• Are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical or inhaled corticosteroid medicines or if you have prurigo nodularis and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT works by blocking a protein that contributes to a type of inflammation that plays a major role in prurigo nodularis.

DUPIXENT helps control a source of unwanted inflammation under the surface to keep you one step ahead of PN symptoms.

It is not known if DUPIXENT can affect the immune response to parasitic (helminth) infections.

DUPIXENT is given as an injection under the skin (subcutaneous injection) at different injection sites. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider.

The recommended dose of DUPIXENT is specified in the table below.

The recommended dose of DUPIXENT for patients ages 18+ years is:

Talk to your healthcare professional and see the detailed Instructions for Use that comes with DUPIXENT for information on how to prepare and inject DUPIXENT and how to properly store and throw away (dispose of) used DUPIXENT Pre-filled Syringes or DUPIXENT Pre-filled Pens prior to taking the drug.

Get supplemental injection support after your doctor shows you the right way to take DUPIXENT.

GET THE PRE-FILLED PEN INSTRUCTIONS FOR USE

If you miss a dose of DUPIXENT: Give the DUPIXENT injection within 7 days from the missed dose, then continue with your original schedule. If the missed dose is not given within 7 days, wait until the next scheduled dose to give your DUPIXENT injection.

Speak with your healthcare provider before making any change to your treatment regimen.

No, you should always follow your healthcare provider’s instructions for dosing and how to give injections.

DUPIXENT should be refrigerated at 36°F to 46°F in the original carton to protect from light. If necessary, DUPIXENT may be kept at room temperature up to 77°F (25°C) for a maximum of 14 days. Do not store above 77°F (25°C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded.

Do not expose DUPIXENT to heat or direct sunlight.

Do not freeze. Do not shake.

Please refer to the DUPIXENT Instructions for Use for complete storage instructions.

Whether you are traveling or not, it’s important to store DUPIXENT in the original carton to protect it from light.

Store refrigerated at 36°F to 46°F (2°C to 8°C) in the original carton to protect from light. If necessary, DUPIXENT may be kept at room temperature up to 77°F (25°C) for a maximum of 14 days. Do not store above 77°F (25°C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded.

Yes. You can continue to receive injection support from your doctor or our Injection Support Center, or if your doctor decides that you or your caregiver can give injections, your doctor will train you. Do not self-adminster DUPIXENT unless you have been trained by a doctor. Patients enrolled in DUPIXENT MyWay® will also have access to their Nurse Educator to help with supplemental injection training.

For more information about DUPIXENT support resources, you can enroll in DUPIXENT MyWay®, a program that can provide:

• Tips and tools to help with your prurigo nodularis.
• Supplemental injection training. Your doctor will show you the proper procedure first and decide whether you can self-inject.
• Financial support for eligible commercially insured patients.
• Assistance with insurance questions.
• Assistance locating a pharmacy that can dispense your DUPIXENT prescription.

Sign up or call a support coordinator at 1-844-DUPIXENT (1-844-387-4936), option 1 to learn more.

You can use our Cost and Coverage Tool to learn more about cost options for your insurance situation. For the most accurate information regarding your cost and dispensing of DUPIXENT, speak directly with your insurance provider who knows the details of your plan.

DUPIXENT is likely to be accessed differently than your other medications. DUPIXENT is an injectable medication that requires special shipping and handling. Insurance providers often require use of a specialty pharmacy instead of your local retail pharmacy. DUPIXENT MyWay® can work with your insurance provider to identify a preferred, in-network specialty pharmacy.

If your health plan did not accept the copay card or if you paid the copay because you were not enrolled in this program, we may be able to reimburse you in accordance with program terms.

Submit your request for reimbursement.