Celisa,
Real patient. Individual
results may vary.
Normal Skin
A healthy immune system produces little to no inflammation on the skin
Atopic Dermatitis Skin
Immune systems of those with eczema may produce more inflammation than normal, contributing to flare‑ups on the surface of the skin
Atopic Dermatitis Skin Treated
With DUPIXENT
DUPIXENT may help reduce this inflammation and the symptoms of eczema to help make skin noticeably clearer
DUPIXENT Targets a Source of Underlying Inflammation
How It Works
INDICATION
DUPIXENT is a prescription medicine used to treat adults and children 6 years of age and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.
Important Safety Information
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Please see Important Safety Information throughout video and accompanying full Prescribing Information, including Patient Information.
Atopic dermatitis, the most common form of eczema, can be caused in part by constant inflammation in your body, which can lead to dry, flaky, itchy skin and rash on the surface of your skin. Moderate-to-severe atopic dermatitis can be difficult to manage.
Patients with atopic dermatitis can have some skin with rash and some skin without rash. But even skin without rash may have ongoing, underlying inflammation. This is because the immune system is overactive.
The immune response in atopic dermatitis involves 2 main parts: a weak skin barrier and underlying internal inflammation. With atopic dermatitis, outside substances such as bacteria, viruses, and allergens may enter the weak outer layer of skin more easily than in healthy skin.
As these outside substances enter the body, a signal is sent to the immune system, causing some immune cells in the second layer of skin to overreact.
Even when these outside substances are no longer present, this overreaction continues.
Cytokines, small proteins that affect communication between cells, are part of the inflammatory signal that can cause the symptoms that patients with atopic dermatitis experience.
DUPIXENT is a prescription medicine used to treat adults and children 6 years of age and older with moderate-to- severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.
DUPIXENT works under the skin. When DUPIXENT attaches to certain immune cells, it inhibits an inflammatory signal from these specific cells that contributes to causing atopic dermatitis.
DUPIXENT may help reduce the rash you see and feel on your skin and targets an underlying source of inflammation that could be a root cause of your atopic dermatitis.
In two, 16-week clinical studies with DUPIXENT:
DUPIXENT can cause serious side effects, including allergic reactions, eye problems, joint aches and pain.
The most common side effects in patients with atopic dermatitis include injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, and cold sores in your mouth or on your lips.
Please see additional Important Safety Information throughout and accompanying full Prescribing Information, including Patient Information.
The relationship between how DUPIXENT works in your body and its clinical effects is unknown.
So ask your doctor if DUPIXENT could help heal your skin from within.
Please see additional Important Safety Information throughout and accompanying full Prescribing Information, including Patient Information.
A Look Inside: Understanding the Science
VO:
Please stay tuned until the end of the video for the full Important Safety Information.
Today we’re going to be learning more about uncontrolled moderate-to-severe eczema (atopic dermatitis), and how DUPIXENT® (dupilumab) might be able to help.
Think about how eczema (atopic dermatitis) has impacted your skin.
You have the next possible flare-up, your ongoing symptoms, and trying to manage them.
The topical prescription lotions, creams, and steroid treatments you’ve been prescribed may not be working as well as you would like, and that can be frustrating.
Well, eczema is more than a chronic skin condition that appears on the surface of the skin. It's a disease caused in part by an overactive immune system that leads to more inflammation than normal in your body.
In people with eczema, immune cells in the deeper layers of the skin send too many inflammatory signals to the surface, causing an itchy rash.
This inflammation can cause red, dry patches that lead to ongoing symptoms, like itching and scratching.
And continuous scratching breaks down the outer layer of the skin, which allows germs, irritants, and allergens to get in.
In response to these invaders, your immune system continues to send inflammatory signals to the surface, causing even more redness and itching.
So, what if there was another way to help address a source of inflammation that can cause the itch-scratch cycle?
Let’s take a look at DUPIXENT.
Unlike topical steroids, DUPIXENT works by targeting an underlying source of inflammation deep beneath the skin to help prevent flare-ups on the surface.
DUPIXENT works beneath the skin by attaching to certain proteins on the immune cells, inhibiting—or blocking—some of the inflammatory signals that contribute to eczema.
Think of it like this: There are calls you want to receive, like calls from friends and family.
But then, there are those pesky spam calls.
If you add a spam filter to your phone that helps lower the amount of pesky calls, you can answer the calls you do want to receive.
By blocking some of these overactive signals—much like reducing the number of pesky calls you receive—DUPIXENT helps to reduce the inflammation that leads to symptoms you see and feel on the surface of your skin.
That means clearer skin and noticeably less itch. Of course, as you consider DUPIXENT, it’s good to keep in mind that if you have a parasitic (helminth) infection, you should talk to your doctor about having that treated before starting DUPIXENT.
In a 52-week clinical trial with adults taking DUPIXENT plus a topical corticosteroid (TCS) (compared to those taking a TCS only), nearly 3 times saw clear or almost clear skin (36% at 52 weeks versus 13% on TCS only, and 39% versus 12% not taking DUPIXENT at 16 weeks).
And, nearly 4 times had significant itch reduction at 1 year. (51% at 52 weeks versus 13% on TCS only). 59% saw significantly less itch versus 20% not taking DUPIXENT at 16 weeks, and 18% saw itch reduction in as fast as 2 weeks vs 8% not taking DUPIXENT.
DUPIXENT was studied in 3 clinical trials with more than 2,100 adults with uncontrolled moderate-to-severe eczema.
The most common side effects in patients with atopic dermatitis include injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, and cold sores in your mouth or on your lips.
Remember, eczema is a chronic condition. It’s important to take your medication exactly as your doctor prescribes.
So, get ready to get ahead of your symptoms with DUPIXENT, and roll up those sleeves—DUPIXENT helps heal your skin from within.
How is DUPIXENT Different
DUPIXENT® is a prescription medicine used to treat adults and children 6 years of age and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.
Important Safety Information
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Please see additional Important Safety Information throughout this video and adjacent links for full Prescribing Information.
Individual results with DUPIXENT may vary.
DR. LIO:
When people have tried a number of different topical therapies and they're just not doing well, that's really where DUPIXENT falls. It's for those patients who've really tried in earnest but are still suffering.
DEBBIE:
I learned that DUPIXENT was not a topical or an oral medication. This drug works with my body to help reduce underlying inflammation and potentially clear my skin.
That was probably the most exciting thing that I found out about DUPIXENT, because I always knew that I needed something that was going to work from the inside out.
DR. LIO:
When I introduce DUPIXENT as a treatment for patients, I first explain that it is not an immunosuppressant, because I think many patients are afraid that a systemic medicine would suppress the entire immune system.
I really emphasize that this is a treatment that's going to cool down the inflammation both in the skin and in the rest of the body to help get them some relief.
DEBBIE:
I explored everything, talked to my doctors a lot about it, and asked every question I could, and decided that it was the right thing for me.
VO:
DUPIXENT is a biologic that works by targeting an underlying source of inflammation that could be a
root cause of your uncontrolled moderate-to-severe eczema.DUPIXENT Helps Heal Your Skin From Within™ for noticeably clearer skin and
less itch.DUPIXENT helps control a source of inflammation that contributes to your eczema.
DUPIXENT is not an
immunosuppressant or steroid.Our goal is for you or your loved one to get the most out of
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discussion
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Hear about the importance of working with your doctor to find a treatment that works for you.
Transcript
DUPIXENT (dupilumab) is a prescription medicine used to treat adults and children 6 years of age and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.
Important Safety Information
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Please see additional Important Safety Information throughout this video and adjacent links for full Prescribing Information.
Individual results with DUPIXENT may vary.
Hi, I’m Kathy. I treat my severe atopic dermatitis with DUPIXENT. When I look back at my journey and how I got here, I can tell you that finding the right eczema specialist is very important.
At one point, I was working with a dermatologist and I felt I had my eczema under control. But then I experienced a major flare-up, and my doctor wasn’t sure what else he could do. So, he referred me to another specialist.
I’m really glad that he did!
My new doctor turned out to be an experienced eczema specialist who’s also an assistant clinical professor at a nearby university.
She walked into the exam room, took one look at me, and said, “I know exactly how to help you.”
We started working together, and eventually, my doctor felt that DUPIXENT could help me manage my symptoms. After discussing the risks and benefits, we decided to move forward with treatment.
With DUPIXENT, my skin started to clear over time, and I experienced less itching. Today, I have more control over my eczema symptoms, which is a big relief!
So, if you’re not getting the results you want with your current treatment plan, look for an eczema specialist who can help you explore other options to help control your symptoms.
Sometimes having the right doctor can make a big difference! And now you know a piece of my DUPIXENT journey.
Thanks for watching!
Use this Healthgrades™ tool to easily find nearby
specialists with experience in treating children , teens,
and adults with uncontrolled moderate-to-severe
eczema (atopic dermatitis).
Transcript
VO:
With less moderate-to-severe eczema, why hide your skin if you can help heal your skin from within?
DUPIXENT helps keep you one step ahead of eczema with clearer skin and less itch.
Hide my skin? Not me.
Don't use if you're allergic to DUPIXENT. Serious allergic reactions can occur that can be severe. Tell your doctor about new or worsening eye problems, such as eye pain or vision changes, including blurred vision, joint aches or pains or a parasitic infection. Don't change or stop asthma medicines without talking to your doctor.
Ask your doctor about DUPIXENT.
See the clinical results in adults and children 6 months of age and older by choosing the appropriate audience.