How DUPIXENT Works
Beckham & Cohen,
Real patients. Individual
results may vary.
The role of Inflammation in Atopic Dermatitis
Normal Skin
A healthy immune system produces little to no inflammation on the skin
Atopic Dermatitis Skin
Immune systems of those with eczema may produce more inflammation than normal, contributing to flare‑ups on the surface of the skin
Atopic Dermatitis Skin Treated
With DUPIXENT
DUPIXENT may help reduce this inflammation and the symptoms of eczema to help make skin noticeably clearer
DUPIXENT TARGETS A SOURCE OF UNDERLYING INFLAMMATION
How It Works
INDICATION
DUPIXENT is a prescription medicine used to treat people aged 6 years and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.
Important Safety Information
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Please see Important Safety Information throughout video and accompanying full Prescribing Information, including Patient Information.
Atopic dermatitis, the most common form of eczema, can be caused in part by constant inflammation in your body, which can lead to dry, flaky, itchy skin and rash on the surface of your skin. Moderate-to-severe atopic dermatitis can be difficult to manage.
Patients with atopic dermatitis can have some skin with rash and some skin without rash. But even skin without rash may have ongoing, underlying inflammation. This is because the immune system is overactive.
The immune response in atopic dermatitis involves 2 main parts: a weak skin barrier and underlying internal inflammation. With atopic dermatitis, outside substances such as bacteria, viruses, and allergens may enter the weak outer layer of skin more easily than in healthy skin.
As these outside substances enter the body, a signal is sent to the immune system, causing some immune cells in the second layer of skin to overreact.
Even when these outside substances are no longer present, this overreaction continues.
Cytokines, small proteins that affect communication between cells, are part of the inflammatory signal that can cause the symptoms that patients with atopic dermatitis experience.
DUPIXENT is a prescription medicine used to treat people aged 6 years and older with moderate-to- severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.
DUPIXENT works under the skin. When DUPIXENT attaches to certain immune cells, it inhibits an inflammatory signal from these specific cells that contributes to causing atopic dermatitis.
DUPIXENT may help reduce the rash you see and feel on your skin and continuously manages the inflammation over time, which is a cause of the signs and symptoms of atopic dermatitis.
In two, 16-week clinical studies with DUPIXENT:
- Nearly half of adult patients saw a 75% improvement and some even saw a 90% improvement
- Almost 4 times more adult patients (37%) taking DUPIXENT saw clear or almost clear skin as compared with those not taking DUPIXENT (9%)
- Adult patients experienced significant itch reduction (38% vs 11% not taking DUPIXENT), some as early as 2 weeks (10% vs 2% not taking DUPIXENT)
DUPIXENT can cause serious side effects, including allergic reactions (hypersensitivity) and eye problems.
The most common side effects in patients with atopic dermatitis include injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, and cold sores in your mouth or on your lips.
Please see additional Important Safety Information throughout and accompanying full Prescribing Information, including Patient Information.
The relationship between how DUPIXENT works in your body and its clinical effects is unknown.
So ask your doctor if DUPIXENT could help heal your skin from within.
Please see additional Important Safety Information throughout and accompanying full Prescribing Information, including Patient Information.
HOW IS DUPIXENT DIFFERENT
VO:
DUPIXENT® is a prescription medicine used to treat people aged 6 years and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.
Important Safety Information
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Please see additional Important Safety Information throughout this video and adjacent links for full Prescribing Information.
Before starting DUPIXENT, you should talk to your doctor about all the medical conditions you have and medications you are taking.
You and your doctor should also discuss the potential benefits and risks of treatment with DUPIXENT including the most common side effects such as injection site reactions and some serious side effects such as allergic reactions, including anaphylaxis, and eye problems.
There is no cure for atopic dermatitis. DUPIXENT can help reduce the signs and symptoms of eczema. Patients’ individual results with DUPIXENT may vary.
DR. LIO:
When people have tried a number of different topical therapies and they're just not doing well, that's really where DUPIXENT falls. It's for those patients who've really tried in earnest but are still suffering.
DEBBIE:
I learned that DUPIXENT was not a topical or an oral medication. This drug works with my body to help reduce underlying inflammation and potentially clear my skin.
That was probably the most exciting thing that I found out about DUPIXENT, because I always knew that I needed something that was going to work from the inside out.
DR. LIO:
When I introduce DUPIXENT as a treatment for patients, I first explain that it is not an immunosuppressant, because I think many patients are afraid that a systemic medicine would suppress the entire immune system.
I really emphasize that this is a treatment that's going to cool down the inflammation both in the skin and in the rest of the body to help get them some relief.
DEBBIE:
I explored everything, talked to my doctors a lot about it, and asked every question I could, and decided that it was the right thing for me.
VO:
DUPIXENT: A BREAKTHROUGH eczema treatment
DUPIXENT is a biologic that works by targeting an underlying source of inflammation that could be a root cause of your uncontrolled moderate-to-severe eczema.
HELPS HEAL
DUPIXENT Helps Heal Your Skin From Within™ for noticeably clearer skin and less itch.
HELPS REDUCE INFLAMMATION
DUPIXENT helps control a source of inflammation that contributes to your eczema.
NOT AN IMMUNOSUPPRESSANT
DUPIXENT is not an immunosuppressant or steroid.
Find a Specialist Who
Treats Eczema
Treats Eczema
Use this Healthgrades™ tool to easily find nearby specialists with experience in treating children, teens, and adults with uncontrolled moderate-to-severe eczema (atopic dermatitis).
Sanofi US and Regeneron do not endorse or recommend any particular physician, and search results do not include a comprehensive list of doctors in your area.
Sanofi US and Regeneron do not endorse or recommend any particular physician, and search results do not include a comprehensive list of doctors in your area.
I eventually found out that atopic dermatitis is caused in part by inflammation beneath my skin. It was surprising to learn that the cause was not just on the outside of my skin, that there was a much deeper cause.
- Britton, DUPIXENT MyWay®
Patient Ambassador
Individual results may vary.
More Patient StoriesREAL Patients On Dupixent
See real people who are being treated with DUPIXENT
and are ready to show more skin because they have less eczema. You can also download the patient brochure to have on hand as well.
Individual results may vary.
Get the Dupixent Patient Brochure
Get the Spanish patient brochure
Transcript
VO:
With less moderate-to-severe eczema, why hide your skin?
"Hide my skin?" Not me."
With DUPIXENT, adults saw long-lasting, clearer skin and fast itch relief.
Don't use if you're allergic to DUPIXENT. Serious allergic reactions can occur, including anaphylaxis, which is severe. Tell your doctor about new or worsening eye problems, such as eye pain or vision changes, or a parasitic infection. If you take asthma medicines, don't change or stop them without talking to your doctor.
So help heal your skin from within. And talk to your eczema specialist about DUPIXENT.
View before and after pictures of real patients to see the results of clearer skin after 16 weeks of treatment with DUPIXENT.
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