HOW DUPIXENT WORKS

DUPIXENT TARGETS A SOURCE OF UNDERLYING INFLAMMATION

How It Works

INDICATION

DUPIXENT is a prescription medicine used to treat adults and children 6 months of age and older with moderate-to-severe eczema (atopic dermatitis or AD) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 months of age.

Important Safety Information

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Please see Important Safety Information throughout video and accompanying full Prescribing Information, including Patient Information.

Atopic dermatitis, the most common form of eczema, can be caused in part by constant inflammation in your body, which can lead to dry, flaky, itchy skin and rash on the surface of your skin. Moderate-to-severe atopic dermatitis can be difficult to manage.

Patients with atopic dermatitis can have some skin with rash and some skin without rash. But even skin without rash may have ongoing, underlying inflammation. This is because the immune system is overactive.

The overactive immune response in eczema (atopic dermatitis or AD) involves two main parts: A weak skin barrier and underlying internal inflammation. With atopic dermatitis, outside substances such as bacteria, viruses, and allergens may enter the weak outer layer of skin more easily than in healthy skin.

As these outside substances enter the body, a signal is sent to the immune system, causing some immune cells in the second layer of skin to overreact.

Even when these outside substances are no longer present, this overreaction continues.

Cytokines, small proteins that affect communication between cells, are part of the inflammatory signal that can cause the symptoms that patients with atopic dermatitis experience.

DUPIXENT is a prescription medicine used to treat adults and children 6 months of age and older with moderate-to-severe eczema (atopic dermatitis or AD) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 months of age.

DUPIXENT works under the skin. When DUPIXENT attaches to certain immune cells, it inhibits an inflammatory signal from these specific cells that contributes to causing atopic dermatitis.

DUPIXENT may help reduce the rash you see and feel on your skin and targets an underlying source of inflammation that could be a root cause of your eczema.

In two, 16-week clinical studies with DUPIXENT

• Almost 4 times more adult patients at 16 weeks taking DUPIXENT saw clear or almost clear skin (37% vs 9% not taking DUPIXENT)
• Adult patients experienced significant itch reduction at 16 weeks (38% vs 11% not taking DUPIXENT), some as early as 2 weeks (10% vs 2% not taking DUPIXENT)

DUPIXENT can cause serious side effects, including allergic reactions that can sometimes be severe, eye problems, and joint aches and pain.

The most common side effects in patients with eczema include injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, dry eye, cold sores in your mouth or on your lips, and high count of a certain white blood cell (eosinophilia).

Please see additional Important Safety Information throughout and accompanying full Prescribing Information, including Patient Information.

The relationship between how DUPIXENT works in your body and its clinical effects is unknown.

So, ask your doctor if DUPIXENT could help heal your skin from within.

Please see additional Important Safety Information throughout and accompanying full Prescribing Information, including Patient Information.