A BREAKTHROUGH BIOLOGIC TREATMENT FOR ECZEMA
DUPIXENT is a biologic that works by targeting an underlying source of inflammation that could be a
root cause of your uncontrolled moderate-to-severe eczema. DUPIXENT helps you stay ahead of
symptoms by continuously treating eczema, even between flare-ups.
HELPS REDUCE INFLAMMATION
DUPIXENT helps control a source of
inflammation that contributes to
your eczema signs and symptoms.
NOT AN IMMUNOSUPPRESSANT
DUPIXENT is not an immunosuppressant or steroid.
THE ROLE OF INFLAMMATION IN ECZEMA (ATOPIC DERMATITIS)
Normal Skin
A healthy immune system produces little
to no inflammation on the skin.
Skin With Eczema
Immune systems of those with
eczema may produce more
inflammation than normal,
contributing to flare‑ups on the
surface of the skin.
Eczema Skin Treated
With DUPIXENT
DUPIXENT may help reduce this
inflammation in those with
eczema for noticeably clearer
skin and less itch.
HOW DOES DUPIXENT WORK TO TREAT ECZEMA?
DUPIXENT is a biologic that continuously treats eczema from the inside, even between flare-ups.
Watch the videos below to learn more.
DUPIXENT TARGETS A SOURCE OF UNDERLYING INFLAMMATION
How It Works
INDICATION
DUPIXENT is a prescription medicine used to treat adults and children 6 months of age and older with moderate-to-severe eczema (atopic dermatitis or AD) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 months of age.
Important Safety Information
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Please see Important Safety Information throughout video and accompanying full Prescribing Information, including Patient Information.
Atopic dermatitis, the most common form of eczema, can be caused in part by constant inflammation in your body, which can lead to dry, flaky, itchy skin and rash on the surface of your skin. Moderate-to-severe atopic dermatitis can be difficult to manage.
Patients with atopic dermatitis can have some skin with rash and some skin without rash. But even skin without rash may have ongoing, underlying inflammation. This is because the immune system is overactive.
The overactive immune response in eczema (atopic dermatitis or AD) involves two main parts: A weak skin barrier and underlying internal inflammation. With atopic dermatitis, outside substances such as bacteria, viruses, and allergens may enter the weak outer layer of skin more easily than in healthy skin.
As these outside substances enter the body, a signal is sent to the immune system, causing some immune cells in the second layer of skin to overreact.
Even when these outside substances are no longer present, this overreaction continues.
Cytokines, small proteins that affect communication between cells, are part of the inflammatory signal that can cause the symptoms that patients with atopic dermatitis experience.
DUPIXENT is a prescription medicine used to treat adults and children 6 months of age and older with moderate-to-severe eczema (atopic dermatitis or AD) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 months of age.
DUPIXENT works under the skin. When DUPIXENT attaches to certain immune cells, it inhibits an inflammatory signal from these specific cells that contributes to causing atopic dermatitis.
DUPIXENT may help reduce the rash you see and feel on your skin and targets an underlying source of inflammation that could be a root cause of your eczema.
In two, 16-week clinical studies with DUPIXENT
- Almost 4 times more adult patients at 16 weeks taking DUPIXENT saw clear or almost clear skin (37% vs 9% not taking DUPIXENT)
- Adult patients experienced significant itch reduction at 16 weeks (38% vs 11% not taking DUPIXENT), some as early as 2 weeks (10% vs 2% not taking DUPIXENT)
DUPIXENT can cause serious side effects, including allergic reactions that can sometimes be severe, eye problems, and joint aches and pain.
The most common side effects in patients with eczema include injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, dry eye, cold sores in your mouth or on your lips, and high count of a certain white blood cell (eosinophilia).
Please see additional Important Safety Information throughout and accompanying full Prescribing Information, including Patient Information.
The relationship between how DUPIXENT works in your body and its clinical effects is unknown.
So, ask your doctor if DUPIXENT could help heal your skin from within.
Please see additional Important Safety Information throughout and accompanying full Prescribing Information, including Patient Information.
Important Safety Information and Indication
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:
- have eye problems.
- have a parasitic (helminth) infection.
- are scheduled to receive any vaccinations. You should not receive a “live vaccine” right before and during treatment with DUPIXENT.
- are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
- A pregnancy registry for women who take DUPIXENT during pregnancy collects information about the health of you and your baby. To enroll or get more information call 1-877-311-8972 or go to https://mothertobaby.org/ongoing-study/dupixent/.
- are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Especially tell your healthcare provider if you are taking oral, topical or inhaled corticosteroid medicines or if you have and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.
DUPIXENT can cause serious side effects, including:
- Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
- Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an eye exam if needed.
- Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.
The most common side effects in patients with eczema include injection site reactions, eye and eyelid inflammation, including redness, swelling and itching, sometimes with blurred vision, dry eye, cold sores in your mouth or on your lips, and high count of a certain white blood cell (eosinophilia).
Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider. In children 12 years of age and older, it’s recommended DUPIXENT be administered by or under supervision of an adult. In children 6 months to less than 12 years of age, DUPIXENT should be given by a caregiver.
Please see accompanying full accompanying full Prescribing Information including Patient Information.
Indication
DUPIXENT is a prescription medicine used to treat adults and children 6 months of age and older with moderate-to-severe eczema (atopic dermatitis or AD) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 months of age.
HOW IS DUPIXENT DIFFERENT?
VO:
DUPIXENT is a prescription medicine used to treat adults and children 6 months of age and older with moderate-to-severe eczema (atopic dermatitis or AD) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 months of age.
Important Safety Information
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Please see additional Important Safety Information throughout this video and adjacent links for full Prescribing Information.
Individual results with DUPIXENT may vary.
Sponsored by Regeneron and Sanofi.
Dr. Lio:
When people have tried a number of different topical therapies and they're just not doing well, that's really where DUPIXENT falls. It's for those patients who've really tried in earnest but are still suffering.
Debbie:
I learned that DUPIXENT was not a topical or an oral medication. This drug works with my body to help reduce underlying inflammation and potentially clear my skin.
That was probably the most exciting thing that I found out about DUPIXENT, because I always knew that I needed something that was going to work from the inside out.
Dr. Lio:
When I introduce DUPIXENT as a treatment for patients, I first explain that it is not an immunosuppressant, because I think many patients are afraid that a systemic medicine would suppress the entire immune system.
I really emphasize that this is a treatment that's going to cool down the inflammation both in the skin and in the rest of the body to help get them some relief.
Debbie:
I explored everything, talked to my doctors a lot about it, and asked every question I could, and decided that it was the right thing for me.
Important Safety Information and Indication
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:
- have eye problems.
- have a parasitic (helminth) infection.
- are scheduled to receive any vaccinations. You should not receive a “live vaccine” right before and during treatment with DUPIXENT.
- are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
- A pregnancy registry for women who take DUPIXENT during pregnancy collects information about the health of you and your baby. To enroll or get more information call 1-877-311-8972 or go to https://mothertobaby.org/ongoing-study/dupixent/.
- are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Especially tell your healthcare provider if you are taking oral, topical or inhaled corticosteroid medicines or if you have and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.
DUPIXENT can cause serious side effects, including:
- Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
- Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an eye exam if needed.
- Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.
The most common side effects in patients with eczema include injection site reactions, eye and eyelid inflammation, including redness, swelling and itching, sometimes with blurred vision, dry eye, cold sores in your mouth or on your lips, and high count of a certain white blood cell (eosinophilia).
Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider. In children 12 years of age and older, it’s recommended DUPIXENT be administered by or under supervision of an adult. In children 6 months to less than 12 years of age, DUPIXENT should be given by a caregiver.
Please see accompanying full accompanying full Prescribing Information including Patient Information.
Indication
DUPIXENT is a prescription medicine used to treat adults and children 6 months of age and older with moderate-to-severe eczema (atopic dermatitis or AD) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 months of age.
Get Started With DUPIXENT
Now that you know how DUPIXENT treats eczema, learn more about how you can take the next step in your treatment journey.
Have a Productive Conversation
With Your Doctor
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of your visit to the doctor. Fill out our personalized
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Treats Eczema
Use this Healthgrades™ tool to easily find nearby
specialists with experience in treating children, teens,
and adults with uncontrolled moderate-to-severe
eczema (atopic dermatitis).
Sanofi US and Regeneron do not endorse or recommend any particular physician, and search results do not include a comprehensive list of doctors in your area.
Hear about the importance of working with your doctor to find a treatment that works for you.
Transcript
VO:
DUPIXENT is a prescription medicine used to treat adults and children 6 months of age and older with moderate-to-severe eczema (atopic dermatitis or AD) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 months of age.
Important Safety Information
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Please see additional Important Safety Information throughout this video and adjacent links for full Prescribing Information.
Individual results with DUPIXENT may vary.
Sponsored by Regeneron and Sanofi.
KATHY:
Hi, I’m Kathy. I treat my severe atopic dermatitis with DUPIXENT. When I look back at my journey and how I got here, I can tell you that finding the right eczema specialist is very important.
At one point, I was working with a dermatologist, and I felt I had my eczema under control. But then I experienced a major flare-up, and my doctor wasn’t sure what else he could do. So, he referred me to another specialist, and I’m really glad that he did!
My new doctor turned out to be an experienced eczema specialist who’s also an assistant clinical professor at a nearby university.
She walked into the exam room, took one look at me, and said, “I know exactly how to help you.” We started working together, and eventually, my doctor felt that DUPIXENT could help me manage my symptoms. After discussing the risks and benefits, we decided to move forward with treatment.
With DUPIXENT, my skin started to clear over time, and I experienced less itching. Today, I have more control over my eczema symptoms, which is a big relief! So, if you’re not getting the results you want with your current treatment plan, look for an eczema specialist who can help you explore other options to help control your symptoms. Sometimes having the right doctor can make a big difference! And now you know a piece of my DUPIXENT journey. Thanks for watching!
Important Safety Information and Indication
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:
- have eye problems.
- have a parasitic (helminth) infection.
- are scheduled to receive any vaccinations. You should not receive a “live vaccine” right before and during treatment with DUPIXENT.
- are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
- A pregnancy registry for women who take DUPIXENT during pregnancy collects information about the health of you and your baby. To enroll or get more information call 1-877-311-8972 or go to https://mothertobaby.org/ongoing-study/dupixent/.
- are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Especially tell your healthcare provider if you are taking oral, topical or inhaled corticosteroid medicines or if you have and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.
DUPIXENT can cause serious side effects, including:
- Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
- Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an eye exam if needed.
- Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.
The most common side effects in patients with eczema include injection site reactions, eye and eyelid inflammation, including redness, swelling and itching, sometimes with blurred vision, dry eye, cold sores in your mouth or on your lips, and high count of a certain white blood cell (eosinophilia).
Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider. In children 12 years of age and older, it’s recommended DUPIXENT be administered by or under supervision of an adult. In children 6 months to less than 12 years of age, DUPIXENT should be given by a caregiver.
Please see accompanying full accompanying full Prescribing Information including Patient Information.
Indication
DUPIXENT is a prescription medicine used to treat adults and children 6 months of age and older with moderate-to-severe eczema (atopic dermatitis or AD) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 months of age.
EXPLORE REAL RESULTS
IN ECZEMA PATIENTS
Click below to see the clinical study results in adults and children 6 months of age and older.
INFÓRMATE SOBRE DUPIXENT EN ESPAÑOL
Obtén más información sobre el eczema moderado a grave, descubre cómo funciona DUPIXENT y mucho más.
Visita el sitio web en español para saber todo sobre DUPIXENT.