How DUPIXENT Works

The role of Inflammation in Atopic Dermatitis

Normal Skin
A healthy immune system produces little to no inflammation on the skin

Atopic Dermatitis Skin
Immune systems of those with eczema may produce more inflammation than normal, contributing to flare‑ups on the surface of the skin

Atopic Dermatitis Skin Treated
With DUPIXENT

DUPIXENT may help reduce this inflammation and the symptoms of eczema to help make skin noticeably clearer

DUPIXENT Targets Underlying Inflammation

DUPIXENT is the first biologic for people 12 years of age and older that targets a key type of underlying inflammation in uncontrolled, moderate-to-severe eczema (atopic dermatitis). Watch the video to see how it works.

Transcript

How It Works

INDICATION
DUPIXENT is a prescription medicine used to treat people 12 years and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 12 years of age.

IMPORTANT SAFETY INFORMATION
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT.

Please see Important Safety Information throughout video and accompanying full Prescribing Information, including Patient Information.

Atopic dermatitis, the most common form of eczema, can be caused in part by constant inflammation in your body, which can lead to dry, flaky, itchy skin and rash on the surface of your skin. Moderate-tosevere atopic dermatitis can be difficult to manage.

Patients with atopic dermatitis can have some skin with rash and some skin without rash. But even skin without rash may have ongoing, underlying inflammation. This is because the immune system is overactive.

The immune response in atopic dermatitis involves two main parts:

A weak skin barrier and underlying internal inflammation. With atopic dermatitis, outside substances such as bacteria, viruses, and allergens may enter the weak outer layer of skin more easily than in healthy skin.

As these outside substances enter the body, a signal is sent to the immune system, causing some immune cells in the second layer of skin to overreact.

Even when these outside substances are no longer present, this overreaction continues. Cytokines, small proteins that affect communication between cells, are part of the inflammatory signal that can cause the symptoms that patients with atopic dermatitis experience.

DUPIXENT is a prescription medicine used to treat people 12 years and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 12 years of age.

DUPIXENT works under the skin. When DUPIXENT attaches to certain immune cells, it inhibits an inflammatory signal from these specific cells that contributes to causing atopic dermatitis. DUPIXENT may help reduce the rash you see and feel on your skin, and continuously manages the inflammation over time, which is a cause of the signs and symptoms of atopic dermatitis.

In two, 16-week clinical studies with DUPIXENT

Nearly half of adult patients saw a 75% improvement and some even saw a 90% improvement

Almost 4 times more adult patients (37%) taking DUPIXENT saw clear or almost clear skin as compared with those not taking DUPIXENT (10%)

Adult patients experienced significant itch reduction, some as early as 2 weeks

DUPIXENT can cause serious side effects, including allergic reactions (hypersensitivity), and eye problems.

The most common side effects include injection site reactions, eye and eyelid inflammation, including redness, swelling and itching, pain in the throat (oropharyngeal pain) and cold sores in your mouth or on your lips.

Please see additional Important Safety Information throughout and accompanying full Prescribing Information, including Patient Information.

The relationship between how DUPIXENT works in your body and its clinical effects is unknown.

So ask your doctor if DUPIXENT could help heal your skin from within.

Please see additional Important Safety Information throughout and accompanying full Prescribing Information, including Patient Information.

Since starting treatment with DUPIXENT, my skin is clearer, and my itching is greatly reduced. Of course, I can only tell you about my experience. Everybody reacts to medication differently.

- Jacque, DUPIXENT MyWay®
Patient Ambassador

Individual results may vary.

Watch Jacque’s Story
Find a Specialist Who
Treats Eczema

Use this Healthgrades™ tool to easily find nearby specialists with experience in treating teens and adults with uncontrolled moderate-to-severe eczema (atopic dermatitis).