How DUPIXENT Works

Celisa,
Real patient. Individual
results may vary.

The role of Inflammation in Atopic Dermatitis

Normal skin with no inflammation or signs of atopic dermatitis

Normal Skin
A healthy immune system produces little to no inflammation on the skin

Atopic dermatitis skin showing more inflammation than normal, contributing to flare-ups on the surface of the skin

Atopic Dermatitis Skin
Immune systems of those with eczema may produce more inflammation than normal, contributing to flare‑ups on the surface of the skin

DUPIXENT® (dupilumab) may help reduce this inflammation and the symptoms of eczema to help make skin noticeably clearer

Atopic Dermatitis Skin Treated
With DUPIXENT

DUPIXENT may help reduce this inflammation and the symptoms of eczema to help make skin noticeably clearer

DUPIXENT: A BREAKTHROUGH eczema treatment

DUPIXENT is a biologic that works by targeting an underlying source of inflammation that could be a root cause of your uncontrolled moderate-to-severe eczema.

HELPS HEAL

DUPIXENT Helps Heal Your Skin From Within™ for noticeably clearer skin and less itch.

HELPS REDUCE INFLAMMATION

DUPIXENT helps control a source of inflammation that contributes to your eczema.

NOT AN IMMUNOSUPPRESSANT

DUPIXENT is not an immunosuppressant or steroid.

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Transcript

VO:

DUPIXENT (dupilumab) is a prescription medicine used to treat people 6 years of age and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.

Important Safety Information

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Please see additional Important Safety Information throughout this video and adjacent links for full Prescribing Information.

Individual results with DUPIXENT may vary.

Hi, I’m Kathy. I treat my severe atopic dermatitis with DUPIXENT. When I look back at my journey and how I got here, I can tell you that finding the right eczema specialist is very important.

At one point, I was working with a dermatologist and I felt I had my eczema under control. But then I experienced a major flare-up, and my doctor wasn’t sure what else he could do. So, he referred me to another specialist.

I’m really glad that he did!

My new doctor turned out to be an experienced eczema specialist who’s also an assistant clinical professor at a nearby university.

She walked into the exam room, took one look at me, and said, “I know exactly how to help you.”

We started working together, and eventually, my doctor felt that DUPIXENT could help me manage my symptoms. After discussing the risks and benefits, we decided to move forward with treatment.

With DUPIXENT, my skin started to clear over time, and I experienced less itching. Today, I have more control over my eczema symptoms, which is a big relief!

So, if you’re not getting the results you want with your current treatment plan, look for an eczema specialist who can help you explore other options to help control your symptoms.

Sometimes having the right doctor can make a big difference! And now you know a piece of my DUPIXENT journey.

Thanks for watching!

Important Safety Information and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have eye problems
  • have a parasitic (helminth) infection
  • are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
    • There is a pregnancy exposure registry for women who take DUPIXENT during pregnancy to collect information about the health of you and your baby. Your healthcare provider can enroll you or you may enroll yourself. To get more information about the registry call 1-877-311-8972 or go to https://mothertobaby.org/ongoing-study/dupixent/.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or if you have atopic dermatitis and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions (hypersensitivity), including a severe reaction known as anaphylaxis. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following symptoms: breathing problems, fever, general ill feeling, swollen lymph nodes, swelling of the face, mouth and tongue, hives, itching, fainting, dizziness, feeling lightheaded (low blood pressure), joint pain, or skin rash.
  • Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision.

The most common side effects in patients with atopic dermatitis include injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, and cold sores in your mouth or on your lips.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed. Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it. DUPIXENT is an injection given under the skin (subcutaneous injection). If your healthcare provider decides that you or a caregiver can give DUPIXENT injections, you or your caregiver should receive training on the right way to prepare and inject DUPIXENT. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider. In children 12 years of age and older, it is recommended that DUPIXENT be administered by or under supervision of an adult. In children younger than 12 years of age, DUPIXENT should be given by a caregiver.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used to treat people aged 6 years and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.

Find a Specialist Who
Treats Eczema

Use this Healthgrades™ tool to easily find nearby
specialists with experience in treating children, teens,
and adults with uncontrolled moderate-to-severe
eczema (atopic dermatitis).

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DOWNLOAD THE PATIENT BROCHURE

Looking for DUPIXENT information you can download or
print out? Download the patient brochure to have on hand.


Get the Dupixent Patient Brochure


Get the Spanish patient brochure

Transcript

VO:
With less moderate-to-severe eczema, why hide your skin if you can help heal your skin from within?

With DUPIXENT, adults saw long-lasting clearer skin and significantly less itch.

Don’t use if you’re allergic to DUPIXENT. Serious allergic reactions can occur, including anaphylaxis, which is severe. Tell your doctor about new or worsening eye problems such as eye pain or vision changes or parasitic infection. If you take asthma medicines, don’t change or stop them without talking to your doctor.

Talk to your doctor about DUPIXENT.

Important Safety Information and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have eye problems
  • have a parasitic (helminth) infection
  • are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
    • There is a pregnancy exposure registry for women who take DUPIXENT during pregnancy to collect information about the health of you and your baby. Your healthcare provider can enroll you or you may enroll yourself. To get more information about the registry call 1-877-311-8972 or go to https://mothertobaby.org/ongoing-study/dupixent/.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or if you have atopic dermatitis and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions (hypersensitivity), including a severe reaction known as anaphylaxis. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following symptoms: breathing problems, fever, general ill feeling, swollen lymph nodes, swelling of the face, mouth and tongue, hives, itching, fainting, dizziness, feeling lightheaded (low blood pressure), joint pain, or skin rash.
  • Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision.

The most common side effects in patients with atopic dermatitis include injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, and cold sores in your mouth or on your lips.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed. Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it. DUPIXENT is an injection given under the skin (subcutaneous injection). If your healthcare provider decides that you or a caregiver can give DUPIXENT injections, you or your caregiver should receive training on the right way to prepare and inject DUPIXENT. Do not try to inject DUPIXENT until you have been shown the right way by your healthcare provider. In children 12 years of age and older, it is recommended that DUPIXENT be administered by or under supervision of an adult. In children younger than 12 years of age, DUPIXENT should be given by a caregiver.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used to treat people aged 6 years and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.

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