Jennifer – Self Injection

VO:

DUPIXENT® (dupilumab) is a prescription medicine used to treat people 6 years of age and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.

Important Safety Information

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Please see additional Important Safety Information throughout this video and adjacent links for Full Prescribing Information.

Before starting DUPIXENT, you should talk to your doctor about all the medical conditions you have or medications you are taking.

You and your doctor should also discuss the potential benefits and risks of treatment with DUPIXENT including the most common side effects such as injection site reactions and some serious side effects such as allergic reactions, including anaphylaxis, and eye problems.

There is no cure for atopic dermatitis. DUPIXENT can help reduce the signs and symptoms of eczema. Patients’ individual results with DUPIXENT may vary.

JENNIFER:

Hey, I’m Jennifer. DUPIXENT helps me manage my severe atopic dermatitis. So, I want to talk with you today about my DUPIXENT journey. More specifically, how I was able to get used to the idea of self-injection.

When I first heard that DUPIXENT was an injectable, I was like, “Hmm, that’s different.” I’d never injected myself before or even thought about it before.

But I was open to it. I had tried many other treatments in the past and seen mixed results.

I felt that if DUPIXENT was going to help me itch less and give me clearer skin, then I was willing to find a way to become more comfortable with self-injection – and that’s what I did.

My doctor taught me the correct way to inject DUPIXENT under my skin and to rotate the injection site each time.

She also asked me to watch the training video on DUPIXENT.com, which I thought was really helpful.

And I knew that by enrolling in the DUPIXENT MyWay® program I could call and speak with someone if I needed more assistance with self-injection.

When the time came for me to handle self-injections on my own at home, I felt prepared.

So, if you’re a little hesitant about self-injection, I get it. Just know that there are resources available to help.

So now my DUPIXENT self-injection is part of my routine every 2 weeks.

I usually do it in the morning in my kitchen after the syringe warms up to room temperature.

Then I pour my coffee, put my shoes on, and I’m off to work.

Of course, everyone’s experience with DUPIXENT and self-injection may be different.

So, this is where I’m at on my DUPIXENT journey.

Thanks for watching!

Anthony Testimonial

ANTHONY:

I design and install home theaters for a living.

I'm definitely an expert in taking technology that doesn't work together and making it work together.

When it comes to the work that I do, I definitely get to the bottom line of what needs to happen.

But when it comes to my atopic dermatitis, it's been a mystery. It’s been a challenge. It’s been difficult to really pin down how to manage it successfully.

My first flare up happened when I was 9 years old. I remember it like it was yesterday. My skin welted up and got red. The itching was overwhelming.

When I would scratch, it would create open sores. It would flare up. It would get red. It would ooze.

I went to the doctor, and he prescribed me antihistamines, and that didn't work.

I had to go back a few more times and that's when he told me I had atopic dermatitis.

By the time I got into middle school, my eczema was part of my life. You could see it on my face. You could see it on my arms.

At times, it would be so bad around my neck and my shoulders and my arms where, you know, I'd have to, I'd have to hold myself up like this throughout the whole day just so my skin wouldn't, wouldn't tear open.

The doctors that I would see, they would do their best in helping me. I tried a lot of treatments, but ultimately, they fell short for me.

As an adult, my eczema didn't change. It was the same.

I would manage my eczema with prescription topical steroids, and when it got really bad it would be oral prescribed steroids.

I would still get really bad flares regardless of the treatment that I was on, regardless of how well I avoided triggers.It just was, it was a constant. It was extremely frustrating.

VO:
In a moment, you'll hear from Anthony about his experience with uncontrolled severe atopic dermatitis (eczema) and treatment with DUPIXENT® (dupilumab).

DUPIXENT is a prescription medicine used to treat people aged 6 years and older with moderate-to-severe atopic dermatitis (eczema).

Important Safety Information

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Please see additional Important Safety Information throughout this video and adjacent links for Full Prescribing Information.

Individual results with DUPIXENT may vary.

ANTHONY:

Eventually, my eczema specialist told me about a treatment option called DUPIXENT. He thought it might be able to help me.

My doctor spent a lot of time educating me about what was really going on in my body.

I learned that I had this inflammation under my skin that contributes to my atopic dermatitis, and that by reducing the inflammation, DUPIXENT could potentially help improve my symptoms.

My doctor and I weighed the benefits and risks of DUPIXENT, and we decided to go ahead with treatment. There are possible serious side effects with treatment like allergic reactions, including anaphylaxis, and eye problems.

We also talked about common side effects, like injection site reactions, eye and eyelid inflammation (including redness, swelling and itching), and cold sores in the mouth or on the lips.

The idea of self-injecting made me nervous.

But DUPIXENT MyWay® sent a nurse to my house to help me get more familiar with the self-injecting process. My wife and kids made an event out of this.

They also learned about the entire process themselves and had a ton of questions that helped me.

Having a nurse right there by my side was fantastic. It made me feel more relaxed. And now, through practice, through doing it over and over again, it's become second nature for me.

After starting DUPIXENT, I noticed a change. I became less itchy. My skin started to clear up.

The open wounds where it was really irritated and cracked, they started to heal.

It's important to mention that this is my personal experience with DUPIXENT, and individual experiences will vary.

Because of DUPIXENT, I'm now able to manage my atopic dermatitis, my eczema.

Today, I finally feel like I have some control over something that went uncontrolled for so long.

I don't have to spend so much time focusing on my eczema.

And, for me, that's just a really awesome thing.

Ana & Max: Self-Injection

VO:

DUPIXENT® (dupilumab) is a prescription medicine used to treat people aged 6 years and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.

Important Safety Information

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Please see additional Important Safety Information throughout this video and adjacent links for Full Prescribing Information.

Before starting DUPIXENT, you should talk to your doctor about all the medical conditions you have or medications you are taking.

You and your doctor should also discuss the potential benefits and risks of treatment with DUPIXENT including the most common side effects such as injection site reactions and some serious side effects such as allergic reactions, including anaphylaxis, and eye problems.

There is no cure for atopic dermatitis. DUPIXENT can help reduce the signs and symptoms of eczema. Patients’ individual results with DUPIXENT may vary.

MAX:

I prefer self-injection just because I feel like it’s more controlled when I do it.

ANA:

Max had his initial dose of 2 injections under the skin at the doctor’s office. She gave him one injection, and she taught him how to self-inject the second. I thought that we would go back there every 2 weeks to have the injection administered, but he picked it up, and he was very comfortable doing it, and he’s been self-injecting at home ever since.

ANA:

I think it’s great that he can self-inject. It’s great that he can do it at home. We have a scheduled time that he does it. But... I can’t even look.

MAX:

She doesn’t handle it very well. She gets really anxious when I’m doing it.

ANA:

I, myself, am not comfortable with needles, and I – you know, maybe it’s because it’s my son – I still get queasy, and I have to look away. I can’t, but he is ok.

Sue & Annie: Assisted Injection

VO:

DUPIXENT® (dupilumab) is a prescription medicine used to treat people aged 6 years and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.

Important Safety Information

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Please see additional Important Safety Information throughout this video and adjacent links for Full Prescribing Information.

Before starting DUPIXENT, you should talk to your doctor about all the medical conditions you have or medications you are taking.

You and your doctor should also discuss the potential benefits and risks of treatment with DUPIXENT including the most common side effects such as injection site reactions and some serious side effects such as allergic reactions, including anaphylaxis, and eye problems.

There is no cure for atopic dermatitis. DUPIXENT can help reduce the signs and symptoms of eczema. Patients’ individual results with DUPIXENT may vary.

ANNIE:

I prefer assisted injection because I get a little squeamish around needles. I don’t want to look at it. I don’t want to touch it. It’s just not something I’m comfortable with, so I’d rather have somebody else do that.

SUE:

And, actually, we have set it up with our school nurse, who is trained to give Annie her DUPIXENT injections, so she will go to school and get her injection every two weeks. Then, during the summers or if there’s a break, we will have Annie’s grandmother, who is a registered nurse and who is trained to give her those injections, do that for her.

ANNIE:

Although my mom was trained how to do it by my doctor, I’m just not comfortable with her doing it. She did it a couple of times in the beginning, but it’s just something I wasn’t a fan of.

SUE:

I’m the last resort. (Laughs)

The initial dose of two injections went really well.

ANNIE:

Over time, I’ve gotten more comfortable with the DUPIXENT injections. I just take a deep breath, and I know that it’s helping me manage my symptoms, and I just relax, and it’s over with.

Introducing Injection

VO:

DUPIXENT® (dupilumab) is a prescription medicine used to treat people aged 6 years and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.

Important Safety Information

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Please see additional Important Safety Information throughout this video and adjacent links for Full Prescribing Information.

There is no cure for atopic dermatitis. DUPIXENT can help reduce the signs and symptoms of eczema. Patients’ individual results with DUPIXENT may vary.

AMBER:

I was concerned about putting my son Catch on DUPIXENT to control his severe atopic dermatitis because it was an injectable, and I know he doesn’t do well with needles.

CHRISTY:

At first, my daughter Jolie wasn’t thrilled at the idea of receiving an injectable medication. So, we sat down, and we talked about it, and we weighed our options. Jolie thought about it and she said, “You know what, Mommy? I really want to try DUPIXENT. Let’s move forward.”

AMBER:

Catch’s doctor and I discussed DUPIXENT with Catch, letting him know that it was an injectable. We felt that bringing him into the decision process, he would be more comfortable taking the injection, knowing that he made that choice.

CHRISTY:

Before Jolie started DUPIXENT, I told her doctor about all the medical conditions she had and the medications she was taking.

AMBER:

Our doctor and I talked about the potential benefits and risks of treatment.

CHRISTY:

We went over the serious side effects including allergic reactions, like anaphylaxis, and eye problems. We also talked about the most common side effects such as injection site reactions.

AMBER:

Since I’m on DUPIXENT as well to control my severe atopic dermatitis, Catch and I are able to take our injections together, given our dosage scheduling. He feels like I’m in this with him. I was properly instructed by my doctor to give myself the injection as well as Catch. So, I give myself my injection, and then I give Catch his.

CHRISTY:

Jolie prefers that the PA in her pediatric dermatologist’s office administer the injection. They have a wonderful bond, and they’ve developed a great relationship, and my husband and I had talked about also getting trained on administering the medication, but Jolie preferred that the PA actually do it in the office.

AMBER:

I’m really proud of Catch taking his DUPIXENT injection. At first, he resisted, but now he sees the benefits of taking DUPIXENT.

Seeing Results

VO:

DUPIXENT® (dupilumab) is a prescription medicine used to treat people aged 6 years and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 years of age.

Important Safety Information

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Please see additional Important Safety Information throughout this video and adjacent links for Full Prescribing Information.

There is no cure for atopic dermatitis. DUPIXENT can help reduce the signs and symptoms of eczema. Patients’ individual results with DUPIXENT may vary.

AMBER:

My son Catch’s eczema was all-consuming since he was a baby. His skin was raw, scaly and itchy.

CHRISTY:

Growing up, my daughter Jolie’s skin was red and raw from severe eczema, specifically, like, her inner elbow, the back of her knees, her cheeks, behind the ears, and her hands were also another area, and that was a tough one because the hands are very, very hard to hide. Her knuckles were raw and red and open.

AMBER:

I was hopeful DUPIXENT was going to help Catch, but I didn’t know what to expect.

CHRISTY:

Jolie was very self-conscious of her skin and what areas were showing. We just hoped that Jolie’s skin would improve.

AMBER:

Before Catch started DUPIXENT, I talked to his doctor about all the medical conditions he had and the medications he was taking.

CHRISTY:

Our doctor and I talked about the potential benefits and risks of treatment. We went over the serious side effects including allergic reactions, like anaphylaxis, and eye problems.

AMBER:

We also talked about the most common side effects such as injection site reactions.

CHRISTY:

A few weeks after starting DUPIXENT, we gradually started seeing results. So, specifically, her hands. What we saw is that skin became less red. The open skin started to heal and close, and that was very promising.

AMBER:

Catch has this birthmark on his knee that he was born with, and I haven’t been able to see that birthmark in such a long time, but since his skin is clearing, I actually get to see that birthmark again.

CHRISTY:

When we started seeing signs of improvement, there were literal tears of joy, and that’s when we knew, like, we were really onto something here.

AMBER:

Before, Catch felt like he needed to cover up his skin, but now his skin is clear to where he’s wearing shorts and short sleeve shirts again. To me, it’s very exciting because I know, as a child, that’s what he wants to do.